A
Arpana Agrawal
Researcher at Washington University in St. Louis
Publications - 55
Citations - 1886
Arpana Agrawal is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Alcohol dependence & Genome-wide association study. The author has an hindex of 20, co-authored 55 publications receiving 1296 citations.
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Journal ArticleDOI
Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders
Raymond K. Walters,Raymond K. Walters,Renato Polimanti,Emma C. Johnson,Jeanette N. McClintick,Mark Adams,Amy E. Adkins,Fazil Aliev,Silviu-Alin Bacanu,Anthony Batzler,Sarah Bertelsen,Joanna M. Biernacka,Tim B. Bigdeli,Li-Shiun Chen,Toni-Kim Clarke,Yi-Ling Chou,Franziska Degenhardt,Anna R. Docherty,Alexis C. Edwards,Pierre Fontanillas,Jerome C. Foo,Louis Fox,Josef Frank,Ina Giegling,Scott Gordon,Laura M. Hack,Annette M. Hartmann,Sarah M. Hartz,Stefanie Heilmann-Heimbach,Stefan Herms,Stefan Herms,Colin A. Hodgkinson,Per Hoffmann,Per Hoffmann,Jouke-Jan Hottenga,Martin A. Kennedy,Mervi Alanne-Kinnunen,Bettina Konte,Jari Lahti,Marius Lahti-Pulkkinen,Dongbing Lai,Lannie Ligthart,Anu Loukola,Brion S. Maher,Hamdi Mbarek,Andrew M. McIntosh,Matthew B. McQueen,Jacquelyn L. Meyers,Yuri Milaneschi,Teemu Palviainen,John F. Pearson,Roseann E. Peterson,Samuli Ripatti,Euijung Ryu,Nancy L. Saccone,Jessica E. Salvatore,Sandra Sanchez-Roige,Melanie L. Schwandt,Richard Sherva,Fabian Streit,Jana Strohmaier,Nathaniel Thomas,Jen-Chyong Wang,Bradley T. Webb,Robbee Wedow,Leah Wetherill,Amanda G. Wills,Jason D. Boardman,Danfeng Chen,Doo Sup Choi,William E. Copeland,Robert Culverhouse,Norbert Dahmen,Louisa Degenhardt,Benjamin W. Domingue,Sarah L. Elson,Mark A. Frye,Wolfgang Gäbel,Caroline Hayward,Marcus Ising,Margaret Keyes,Falk Kiefer,John Kramer,Samuel Kuperman,Susanne Lucae,Michael T. Lynskey,Wolfgang Maier,Karl Mann,Satu Männistö,Bertram Müller-Myhsok,Alison D. Murray,John I. Nurnberger,Aarno Palotie,Ulrich W. Preuss,Katri Räikkönen,Maureen Reynolds,Monika Ridinger,Norbert Scherbaum,Marc A. Schuckit,Michael Soyka,Michael Soyka,Jens Treutlein,Stephanie H. Witt,Norbert Wodarz,Peter Zill,Daniel E. Adkins,Joseph M. Boden,Dorret I. Boomsma,Laura J. Bierut,Sandra A. Brown,Kathleen K. Bucholz,Sven Cichon,E. Jane Costello,Harriet de Wit,Nancy Diazgranados,Danielle M. Dick,Johan G. Eriksson,Lindsay A. Farrer,Tatiana Foroud,Nathan A. Gillespie,Alison Goate,David Goldman,Richard A. Grucza,Dana B. Hancock,Kathleen Mullan Harris,Andrew C. Heath,Victor Hesselbrock,John K. Hewitt,Christian J. Hopfer,John Horwood,William G. Iacono,Eric O. Johnson,Jaakko Kaprio,Victor M. Karpyak,Kenneth S. Kendler,Henry R. Kranzler,Kenneth Krauter,Paul Lichtenstein,Penelope A. Lind,Matt McGue,James MacKillop,Pamela A. F. Madden,Hermine H. Maes,Patrik K. E. Magnusson,Nicholas G. Martin,Sarah E. Medland,Grant W. Montgomery,Elliot C. Nelson,Markus M. Nöthen,Abraham A. Palmer,Nancy L. Pedersen,Brenda W. J. H. Penninx,Bernice Porjesz,John P. Rice,Marcella Rietschel,Brien P. Riley,Richard J. Rose,Dan Rujescu,Pei-Hong Shen,Judy L. Silberg,Michael C. Stallings,Ralph E. Tarter,Michael M. Vanyukov,Scott I. Vrieze,Tamara L. Wall,John Whitfield,Hongyu Zhao,Benjamin M. Neale,Benjamin M. Neale,Joel Gelernter,Howard J. Edenberg,Arpana Agrawal +171 more
TL;DR: The largest genome-wide association study to date of DSM-IV-diagnosed AD found loci associated with AD and characterized the relationship between AD and other psychiatric and behavioral outcomes, underscoring the genetic distinction between pathological and nonpathological drinking behaviors.
Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders
Raymond K. Walters,Raymond K. Walters,Renato Polimanti,Emma C. Johnson,Jeanette N. McClintick,Mark Adams,Amy E. Adkins,Fazil Aliev,Silviu-Alin Bacanu,Anthony Batzler,Sarah Bertelsen,Joanna M. Biernacka,Tim B. Bigdeli,Li-Shiun Chen,Toni-Kim Clarke,Yi-Ling Chou,Franziska Degenhardt,Anna R. Docherty,Alexis C. Edwards,Pierre Fontanillas,Jerome C. Foo,Louis Fox,Josef Frank,Ina Giegling,Scott Gordon,Laura M. Hack,Annette M. Hartmann,Sarah M. Hartz,Stefanie Heilmann-Heimbach,Stefan Herms,Stefan Herms,Colin A. Hodgkinson,Per Hoffmann,Per Hoffmann,Jouke-Jan Hottenga,Martin A. Kennedy,Mervi Alanne-Kinnunen,Bettina Konte,Jari Lahti,Marius Lahti-Pulkkinen,Dongbing Lai,Lannie Ligthart,Anu Loukola,Brion S. Maher,Hamdi Mbarek,Andrew M. McIntosh,Matthew B. McQueen,Jacquelyn L. Meyers,Yuri Milaneschi,Teemu Palviainen,John F. Pearson,Roseann E. Peterson,Samuli Ripatti,Euijung Ryu,Nancy L. Saccone,Jessica E. Salvatore,Sandra Sanchez-Roige,Melanie L. Schwandt,Richard Sherva,Fabian Streit,Jana Strohmaier,Nathaniel Thomas,Jen-Chyong Wang,Bradley T. Webb,Robbee Wedow,Leah Wetherill,Amanda G. Wills,Jason D. Boardman,Danfeng Chen,Doo Sup Choi,William E. Copeland,Robert Culverhouse,Norbert Dahmen,Louisa Degenhardt,Benjamin W. Domingue,Sarah L. Elson,Mark A. Frye,Wolfgang Gäbel,Caroline Hayward,Marcus Ising,Margaret Keyes,Falk Kiefer,John Kramer,Samuel Kuperman,Susanne Lucae,Michael T. Lynskey,Wolfgang Maier,Karl Mann,Satu Männistö,Bertram Müller-Myhsok,Alison D. Murray,John I. Nurnberger,Aarno Palotie,Ulrich W. Preuss,Katri Räikkönen,Maureen Reynolds,Monika Ridinger,Norbert Scherbaum,Marc A. Schuckit,Michael Soyka,Michael Soyka,Jens Treutlein,Stephanie H. Witt,Norbert Wodarz,Peter Zill,Daniel E. Adkins,Joseph M. Boden,Dorret I. Boomsma,Laura J. Bierut,Sandra A. Brown,Kathleen K. Bucholz,Sven Cichon,E. Jane Costello,Harriet de Wit,Nancy Diazgranados,Danielle M. Dick,Johan G. Eriksson,Lindsay A. Farrer,Tatiana Foroud,Nathan A. Gillespie,Alison Goate,David Goldman,Richard A. Grucza,Dana B. Hancock,Kathleen Mullan Harris,Andrew C. Heath,Victor Hesselbrock,John K. Hewitt,Christian J. Hopfer,John Horwood,William G. Iacono,Eric O. Johnson,Jaakko Kaprio,Victor M. Karpyak,Kenneth S. Kendler,Henry R. Kranzler,Kenneth Krauter,Paul Lichtenstein,Penelope A. Lind,Matt McGue,James MacKillop,Pamela A. F. Madden,Hermine H. Maes,Patrik K. E. Magnusson,Nicholas G. Martin,Sarah E. Medland,Grant W. Montgomery,Elliot C. Nelson,Markus M. Nöthen,Abraham A. Palmer,Nancy L. Pedersen,Brenda W. J. H. Penninx,Bernice Porjesz,John P. Rice,Marcella Rietschel,Brien P. Riley,Richard J. Rose,Dan Rujescu,Pei-Hong Shen,Judy L. Silberg,Michael C. Stallings,Ralph E. Tarter,Michael M. Vanyukov,Scott I. Vrieze,Tamara L. Wall,John Whitfield,Hongyu Zhao,Benjamin M. Neale,Benjamin M. Neale,Joel Gelernter,Howard J. Edenberg,Arpana Agrawal +171 more
TL;DR: The largest GWAS to date of DSM - IV diagnosed AD found loci associated with AD and the relationship between AD and other psychiatric and behavioral outcomes, underscoring the genetic distinction between pathological and non - pathological drinking behaviors.
The genetic association between personality and major depression or bipolar disorder. A polygenic score analysis using genome-wide association data
Christel M. Middeldorp,Christel M. Middeldorp,M.H.M. de Moor,Lauren M. McGrath,Sarah Gordon,Douglas Blackwood,Paul T. Costa,Antonio Terracciano,Robert F. Krueger,E.J.C. de Geus,Dale R. Nyholt,Toshiko Tanaka,Tõnu Esko,Tõnu Esko,Paul Madden,Jaime Derringer,Najaf Amin,Gonneke Willemsen,Jouke-Jan Hottenga,Marijn A. Distel,Manuela Uda,Serena Sanna,Philip Spinhoven,Catharina A. Hartman,Stephan Ripke,Stephan Ripke,Patrick F. Sullivan,Anu Realo,Jüri Allik,Andrew C. Heath,Michele L. Pergadia,Arpana Agrawal,Peng Lin,Richard A. Grucza,Elisabeth Widen,Diana L. Cousminer,Johan G. Eriksson,Aarno Palotie,Jennifer H. Barnett,Jennifer H. Barnett,Phil Lee,Michelle Luciano,Albert Tenesa,Gary Davies,Lorna M. Lopez,Narelle K. Hansell,Sarah E. Medland,Luigi Ferrucci,David Schlessinger,Grant W. Montgomery,Margie Wright,Yurii S. Aulchenko,A. C. J. W. Janssens,Ben A. Oostra,Andres Metspalu,Andres Metspalu,Gonçalo R. Abecasis,Ian J. Deary,Katri Räikkönen,Laura J. Bierut,Nicholas G. Martin,Naomi R. Wray,C M van Duijn,Jordan W. Smoller,Brenda W.J.H. Penninx,Brenda W.J.H. Penninx,Brenda W.J.H. Penninx,Dorret I. Boomsma +67 more
TL;DR: For example, this article examined the genetic association between personality and major depressive disorder (MDD) and bipolar disorder (BD) by applying polygenic scores for neuroticism, extraversion, openness to experience, agreeableness and conscientiousness to both disorders.
Journal ArticleDOI
The genetic association between personality and major depression or bipolar disorder. A polygenic score analysis using genome-wide association data
Christel M. Middeldorp,Christel M. Middeldorp,M.H.M. de Moor,Lauren M. McGrath,Sarah Gordon,Douglas Blackwood,Paul T. Costa,Antonio Terracciano,Robert F. Krueger,E.J.C. de Geus,Dale R. Nyholt,Toshiko Tanaka,Tõnu Esko,Tõnu Esko,Paul Madden,Jaime Derringer,Najaf Amin,Gonneke Willemsen,Jouke-Jan Hottenga,Marijn A. Distel,Manuela Uda,Serena Sanna,Philip Spinhoven,Catharina A. Hartman,Stephan Ripke,Stephan Ripke,Patrick F. Sullivan,Anu Realo,Jüri Allik,Andrew C. Heath,Michele L. Pergadia,Arpana Agrawal,Peng Lin,Richard A. Grucza,Elisabeth Widen,Diana L. Cousminer,Johan G. Eriksson,Aarno Palotie,Jennifer H. Barnett,Jennifer H. Barnett,Phil Lee,Michelle Luciano,Albert Tenesa,Gary Davies,Lorna M. Lopez,Narelle K. Hansell,Sarah E. Medland,Luigi Ferrucci,David Schlessinger,Grant W. Montgomery,Margie Wright,Yurii S. Aulchenko,A. C. J. W. Janssens,Ben A. Oostra,Andres Metspalu,Andres Metspalu,Gonçalo R. Abecasis,Ian J. Deary,Katri Räikkönen,Laura J. Bierut,Nicholas G. Martin,Naomi R. Wray,C M van Duijn,Jordan W. Smoller,Brenda W.J.H. Penninx,Brenda W.J.H. Penninx,Brenda W.J.H. Penninx,Dorret I. Boomsma +67 more
TL;DR: In this paper, the authors examined the genetic association between personality and major depressive disorder (MDD) and bipolar disorder (BD) by applying polygenic scores for neuroticism, extraversion, openness to experience, agreeableness and conscientiousness to both disorders.
Journal ArticleDOI
Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci.
A. Mesut Erzurumluoglu,Mengzhen Liu,Victoria E. Jackson,Victoria E. Jackson,Victoria E. Jackson,Daniel R. Barnes,Gargi Datta,Gargi Datta,Carl A. Melbourne,Robin Young,Chiara Batini,Praveen Surendran,Tao Jiang,Sheikh Daud Adnan,Saima Afaq,Arpana Agrawal,Elisabeth Altmaier,Antonis C. Antoniou,Folkert W. Asselbergs,Clemens Baumbach,Laura J. Bierut,Sarah Bertelsen,Michael Boehnke,Michiel L. Bots,David M. Brazel,John C. Chambers,Jenny Chang-Claude,Jenny Chang-Claude,Chu Chen,Chu Chen,Janie Corley,Yi-Ling Chou,Sean P. David,Rudolf A. de Boer,Christiaan de Leeuw,Joe Dennis,Anna F. Dominiczak,Alison M. Dunning,Douglas F. Easton,Charles B. Eaton,Paul Elliott,Evangelos Evangelou,Evangelos Evangelou,Jessica D. Faul,Tatiana Foroud,Alison Goate,Jian Gong,Hans J. Grabe,Jeffrey Haessler,Christopher A. Haiman,Göran Hallmans,Anke R. Hammerschlag,Sarah E. Harris,Andrew T. Hattersley,Andrew C. Heath,Chris Hsu,William G. Iacono,Stavroula Kanoni,Manav Kapoor,Jaakko Kaprio,Sharon L.R. Kardia,Fredrik Karpe,Fredrik Karpe,Jukka Kontto,Jaspal S. Kooner,Charles Kooperberg,Charles Kooperberg,Kari Kuulasmaa,Markku Laakso,Dongbing Lai,Claudia Langenberg,Nhung Le,Guillaume Lettre,Guillaume Lettre,Anu Loukola,Jian'an Luan,Pamela A. F. Madden,Massimo Mangino,Massimo Mangino,Riccardo E. Marioni,Eirini Marouli,Jonathan Marten,Nicholas G. Martin,Matt McGue,Kyriaki Michailidou,Kyriaki Michailidou,Evelin Mihailov,Alireza Moayyeri,Marie Moitry,Martina Müller-Nurasyid,Aliya Naheed,Matthias Nauck,Matt Neville,Matt Neville,Sune F. Nielsen,Kari E. North,Markus Perola,Markus Perola,Paul D.P. Pharoah,Giorgio Pistis,Tinca J. C. Polderman,Danielle Posthuma,Neil Poulter,Beenish Qaiser,Asif Rasheed,Alex P. Reiner,Alex P. Reiner,Frida Renström,Frida Renström,John P. Rice,Rebecca Rohde,Olov Rolandsson,Nilesh J. Samani,Maria Samuel,David Schlessinger,Steven Scholte,Robert A. Scott,Peter S. Sever,Peter S. Sever,Yaming Shao,Nick Shrine,Jennifer A. Smith,John M. Starr,Kathleen Stirrups,Kathleen Stirrups,Danielle Stram,Heather M. Stringham,Ioanna Tachmazidou,Jean-Claude Tardif,Jean-Claude Tardif,Deborah J. Thompson,Hilary A. Tindle,Vinicius Tragante,Stella Trompet,Valérie Turcot,Jessica Tyrrell,Ilonca Vaartjes,Andries R. van der Leij,Peter van der Meer,Tibor V. Varga,Niek Verweij,Niek Verweij,Henry Völzke,Nicholas J. Wareham,Helen R. Warren,David R. Weir,Stefan Weiss,Stefan Weiss,Leah Wetherill,Hanieh Yaghootkar,Ersin Yavas,Ersin Yavas,Yu Jiang,Fang Chen,Xiaowei Zhan,Weihua Zhang,Weihua Zhang,Wei Zhao,Kaixin Zhou,Philippe Amouyel,Stefan Blankenberg,Mark J. Caulfield,Rajiv Chowdhury,Francesco Cucca,Ian J. Deary,Panos Deloukas,Panos Deloukas,Panos Deloukas,Emanuele Di Angelantonio,Emanuele Di Angelantonio,Marco M Ferrario,Jean Ferrières,Paul W. Franks,Paul W. Franks,Timothy M. Frayling,Philippe M. Frossard,Ian P. Hall,Caroline Hayward,Jan-Håkan Jansson,J. Wouter Jukema,Frank Kee,Satu Männistö,Andres Metspalu,Patricia B. Munroe,Børge G. Nordestgaard,Colin N. A. Palmer,Veikko Salomaa,Naveed Sattar,Tim D. Spector,David P. Strachan,Pim van der Harst,Eleftheria Zeggini,Danish Saleheen,Danish Saleheen,Adam S. Butterworth,Adam S. Butterworth,Louise V. Wain,Louise V. Wain,Gonçalo R. Abecasis,John Danesh,John Danesh,John Danesh,Martin D. Tobin,Martin D. Tobin,Scott I. Vrieze,Dajiang J. Liu,Joanna M. M. Howson +206 more
TL;DR: The novel loci will facilitate understanding the genetic aetiology of smoking behaviour and may lead to the identification of potential drug targets for smoking prevention and/or cessation.