M
Manolis Kellis
Researcher at Massachusetts Institute of Technology
Publications - 448
Citations - 132627
Manolis Kellis is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Gene & Genome. The author has an hindex of 128, co-authored 405 publications receiving 112181 citations. Previous affiliations of Manolis Kellis include Broad Institute & Epigenomics AG.
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Journal ArticleDOI
RANGER-DTL 2.0: rigorous reconstruction of gene-family evolution by duplication, transfer and loss.
TL;DR: RANGER-DTL 2.0 has a particular focus on reconciliation accuracy and can account for many sources of reconciliation uncertainty including uncertain gene tree rooting, gene tree topological uncertainty, multiple optimal reconciliations and alternative event cost assignments.
Journal ArticleDOI
PRC2 Is Required to Maintain Expression of the Maternal Gtl2-Rian-Mirg Locus by Preventing De Novo DNA Methylation in Mouse Embryonic Stem Cells
Partha Pratim Das,Partha Pratim Das,David A. Hendrix,David A. Hendrix,Effie Apostolou,Effie Apostolou,Alice H. Buchner,Alice H. Buchner,Matthew C. Canver,Semir Beyaz,Damir Ljuboja,Rachael Kuintzle,Woojin Kim,Rahul Karnik,Rahul Karnik,Zhen Shao,Huafeng Xie,Jian Xu,Alejandro De Los Angeles,Yingying Zhang,Yingying Zhang,Jun-Ho Choe,Don Leong Jia Jun,Don Leong Jia Jun,Xiaohua Shen,Xiaohua Shen,Richard I. Gregory,George Q. Daley,George Q. Daley,Alexander Meissner,Alexander Meissner,Manolis Kellis,Konrad Hochedlinger,Konrad Hochedlinger,Jonghwan Kim,Stuart H. Orkin,Stuart H. Orkin +36 more
TL;DR: In this article, it was shown that PRC2 is required to maintain expression of maternal microRNAs and long non-coding RNAs from the Gtl2-Rian-Mirg locus, which is essential for full pluripotency of iPSCs.
Posted ContentDOI
SARS-CoV-2 gene content and COVID-19 mutation impact by comparing 44 Sarbecovirus genomes.
TL;DR: Comparative genomics is used to provide a high-confidence protein-coding gene set, characterize protein-level and nucleotide-level evolutionary constraint, and prioritize functional mutations from the ongoing COVID-19 pandemic.
Human Primordial Germ Cells Are Specified from Lineage-Primed Progenitors
Di Chen,Na Sun,Na Sun,Lei Hou,Lei Hou,Rachel Kim,Jared Faith,Marianna Aslanyan,Yu Tao,Yi Zheng,Jianping Fu,Wanlu Liu,Manolis Kellis,Manolis Kellis,Amander T. Clark +14 more
TL;DR: It is shown that human PGC (hPGC) specification begins at day 12 post-fertilization and serves to protect hPGCLCs from crossing the Weismann’s barrier to adopt somatic cell fates and, therefore, is an essential mechanism for successfully initiating in vitro gametogenesis.
Computational analysis of noncoding RNAs
Stefan Washietl,Sebastian Will,David A. Hendrix,Loyal A. Goff,Loyal A. Goff,John L. Rinn,John L. Rinn,Bonnie Berger,Manolis Kellis +8 more
TL;DR: Computational methods to analyze noncoding RNAs include basic and advanced techniques to predict RNA structures, annotation of nonc coding RNAs in genomic data, mining RNA‐seq data for novel transcripts and prediction of transcript structures, computational aspects of microRNAs, and database resources.