M
Manolis Kellis
Researcher at Massachusetts Institute of Technology
Publications - 448
Citations - 132627
Manolis Kellis is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Gene & Genome. The author has an hindex of 128, co-authored 405 publications receiving 112181 citations. Previous affiliations of Manolis Kellis include Broad Institute & Epigenomics AG.
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Journal ArticleDOI
Network deconvolution as a general method to distinguish direct dependencies in networks
Soheil Feizi,Soheil Feizi,Daniel Marbach,Daniel Marbach,Muriel Medard,Manolis Kellis,Manolis Kellis +6 more
TL;DR: This work presents a general method for inferring direct effects from an observed correlation matrix containing both direct and indirect effects, and introduces an algorithm that removes the combined effect of all indirect paths of arbitrary length in a closed-form solution by exploiting eigen-decomposition and infinite-series sums.
Common Variants at 9p21 and 8q22 Are Associated with Increased Susceptibility to Optic Nerve Degeneration in Glaucoma
Janey L. Wiggs,Brian L. Yaspan,Michael A. Hauser,Jae H. Kang,R. Rand Allingham,Lana M. Olson,Wael Abdrabou,Baojian Fan,Dan Y. Wang,Wendy Brodeur,Donald L. Budenz,Joseph Caprioli,Andrew Crenshaw,Kristy Crooks,E. DelBono,Kimberly F. Doheny,David S. Friedman,Douglas E. Gaasterland,Terry Gaasterland,Cathy C. Laurie,Richard K. Lee,Paul R. Lichter,Stephanie Loomis,Yutao Liu,Felipe A. Medeiros,Catherine A. McCarty,Daniel B. Mirel,Sayoko E. Moroi,David C. Musch,Anthony Realini,Frank W. Rozsa,Joel S. Schuman,Kathleen M. Scott,Kuldev Singh,Joshua D. Stein,Edward H. Trager,Paul C. VanVeldhuisen,Douglas Vollrath,Gadi Wollstein,Sachiko Yoneyama,Kang Zhang,Robert N. Weinreb,Jason Ernst,Manolis Kellis,Tomohiro Masuda,Donald J. Zack,Julia E. Richards,Margaret A. Pericak-Vance,Louis R. Pasquale,Jonathan L. Haines +49 more
TL;DR: It is suggested that neuro-protective therapies targeting TGF-beta signaling could be effective for multiple forms of glaucoma, and genomic pathway analysis showed an association between the T GF-beta pathway and NPG.
Journal ArticleDOI
The Tasmanian devil transcriptome reveals Schwann cell origins of a clonally transmissible cancer
Elizabeth P. Murchison,Cesar Tovar,Arthur Hsu,Hannah S. Bender,Hannah S. Bender,Pouya Kheradpour,Clare A. Rebbeck,DL Obendorf,Carly Conlan,Melanie Bahlo,Catherine A. Blizzard,Stephen Pyecroft,Alexandre Kreiss,Manolis Kellis,Manolis Kellis,Alexander Stark,Alexander Stark,Timothy T. Harkins,Jennifer A. Marshall Graves,Gregory M. Woods,Gregory J. Hannon,Anthony T. Papenfuss +21 more
TL;DR: These studies confirm that DFTD is a monophyletic clonally transmissible tumor and suggest that the disease is of Schwann cell origin and provide a genomic data set for the Tasmanian devil that is applicable to cancer diagnosis, disease evolution, and conservation biology.
Book ChapterDOI
Discovery and characterization of chromatin states for systematic annotation of the human genome
Jason Ernst,Manolis Kellis +1 more
TL;DR: A multivariate Hidden Markov Model is used to reveal chromatin states in human T cells, based on recurrent and spatially coherent combinations of chromatin marks, providing a complementary functional annotation of the human genome that reveals the genome-wide locations of diverse classes of epigenetic function.
Journal ArticleDOI
A single Hox locus in Drosophila produces functional microRNAs from opposite DNA strands
Alexander Stark,Natascha Bushati,Calvin H. Jan,Pouya Kheradpour,Emily Hodges,Julius Brennecke,David P. Bartel,Stephen M. Cohen,Manolis Kellis +8 more
TL;DR: It is reported that the miRNA iab-4 locus in the Drosophila Hox cluster is transcribed convergently from both DNA strands, giving rise to two distinct functional miRNAs.