M
Manolis Kellis
Researcher at Massachusetts Institute of Technology
Publications - 448
Citations - 132627
Manolis Kellis is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Gene & Genome. The author has an hindex of 128, co-authored 405 publications receiving 112181 citations. Previous affiliations of Manolis Kellis include Broad Institute & Epigenomics AG.
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Journal Article
Predictive Regulatory Models in of Transcriptional Networks
Daniel Marbach,Sushmita Roy,Ferhat Ay,Patrick E. Meyer,Rogerio Candeias,Tamer Kahveci,Christopher A. Bristow,Manolis Kellis +7 more
TL;DR: This paper aims to demonstrate the efforts towards in-situ applicability of EMMARM, which aims to provide real-time information about the physical properties of concrete mechanical properties such as E-modulus and restitution.
The Genotype-Tissue Expression (GTEx) project
John T. Lonsdale,Jeffrey Thomas,Mike Salvatore,Rebecca Phillips,Edmund Lo,Saboor Shad,Richard Hasz,Gary Walters,Fernando U. Garcia,Nancy Young,Barbara A. Foster,Mike Moser,Ellen Karasik,Bryan Gillard,Kimberley Ramsey,Susan L. Sullivan,Jason Bridge,Harold Magazine,John Syron,Johnelle Fleming,Laura A. Siminoff,Heather M. Traino,Maghboeba Mosavel,Laura Barker,Scott D. Jewell,Daniel C. Rohrer,Dan Maxim,Dana Filkins,Philip Harbach,Eddie Cortadillo,Bree Berghuis,Lisa Turner,Eric Hudson,Kristin Feenstra,Leslie H. Sobin,James A. Robb,Phillip Branton,Greg E. Korzeniewski,Charles Shive,David Tabor,Liqun Qi,Kevin Groch,Sreenath Nampally,Steve Buia,Angela Zimmerman,Anna M. Smith,Robin Burges,Karna Robinson,Kim Valentino,Deborah Bradbury,Mark Cosentino,Norma Diaz-Mayoral,Mary Kennedy,Theresa Engel,Penelope Williams,Kenyon Erickson,Kristin G. Ardlie,Wendy Winckler,Gad Getz,David S. DeLuca,Daniel G. MacArthur,Manolis Kellis,Alexander Thomson,Taylor Young,Ellen Gelfand,Molly Donovan,Yan Meng,George B. Grant,Deborah C. Mash,Yvonne Marcus,Margaret J. Basile,Jun Liu,Jun Zhu,Zhidong Tu,Nancy J. Cox,Dan L. Nicolae,Eric R. Gamazon,Hae Kyung Im,Anuar Konkashbaev,Jonathan K. Pritchard,Matthew Stevens,Timothée Flutre,Xiaoquan Wen,Emmanouil T. Dermitzakis,Tuuli Lappalainen,Roderic Guigó,Jean Monlong,Michael Sammeth,Daphne Koller,Alexis Battle,Sara Mostafavi,Mark I. McCarthy,Manual Rivas,Julian Maller,Ivan Rusyn,Andrew B. Nobel,Fred A. Wright,Andrey A. Shabalin,Mike Feolo,Nataliya Sharopova,Anne Sturcke,Justin Paschal,James M. Anderson,Elizabeth L. Wilder,Leslie Derr,Eric D. Green,Jeffery P. Struewing,Gary F. Temple,Simona Volpi,Joy T. Boyer,Elizabeth J. Thomson,Mark S. Guyer,Cathy Ng,Assya Abdallah,Deborah Colantuoni,Thomas R. Insel,Susan E. Koester,A. Roger Little,Patrick Bender,Thomas Lehner,Yin Yao,Carolyn C. Compton,Jimmie B. Vaught,Sherilyn Sawyer,Nicole C. Lockhart,Joanne P. Demchok,Helen F. Moore +126 more
TL;DR: In this article, the authors proposed a new method for the detection of cancer using a set of genes extracted from the human brain, which they called LSTM-CRF.
Proceedings ArticleDOI
Abstract A35: BRAF inhibition increases exosomal PD-L1 protein expression in melanoma
Gyulnara G. Kasumova,Alvin Shi,Jessica Cintolo-Gonzalez,Isabel Chein,Dennie T. Frederick,Roman Alpatov,William A. Michaud,Deborah Plana,David J. Panka,Ryan B. Corcoran,Keith T. Flaherty,Ryan J. Sullivan,Manolis Kellis,Genevieve M. Boland +13 more
TL;DR: It is confirmed that exosomes from cell lines and patient samples express PD-L1 that can be serially monitored, and that treatment with BRAF inhibition results in increased PD-l1 levels, which in vitro are persistently elevated in BRAFi resistant cells.
Posted ContentDOI
Single-cell interactomes of the human brain reveal cell-type specific convergence of brain disorders
TL;DR: SCINET (Single-Cell Imputation and NETwork construction), a computational framework that reconstructs an ensemble of cell type-specific interactomes by integrating a global, context-independent reference interactome with a single-cell gene expression profile, is introduced.
Posted ContentDOI
Plasma-derived exosomal analysis and deconvolution enables prediction and tracking of melanoma checkpoint blockade response
Alvin Shi,Alvin Shi,Gyulnara G. Kasumova,William A. Michaud,Jessica Cintolo-Gonzales,Marta Díaz Martínez,Jacqueline Ohmura,Arnav Mehta,Isabel Chien,Dennie T. Frederick,Sonia Cohen,Deborah Plana,Douglas B. Johnson,Keith T. Flaherty,Ryan J. Sullivan,Manolis Kellis,Manolis Kellis,Genevieve M. Boland,Genevieve M. Boland +18 more
TL;DR: Peripheral blood-derived exosomes can serve as a non-invasive biomarker to jointly probe tumor-intrinsic and immune changes to ICI, and can potentially function as predictive markers of ICI responsiveness and a monitoring tool for tumor persistence and immune activation.