M
Manolis Kellis
Researcher at Massachusetts Institute of Technology
Publications - 448
Citations - 132627
Manolis Kellis is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Gene & Genome. The author has an hindex of 128, co-authored 405 publications receiving 112181 citations. Previous affiliations of Manolis Kellis include Broad Institute & Epigenomics AG.
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Journal Article
Unlocking the Secrets of the Genome
Susan E. Celniker,Laura A.L. Dillon,Mark Gerstein,Kristin C. Gunsalus,Steven Henikoff,Gary H. Karpen,Manolis Kellis,Eric C. Lai,Jason D. Lieb,David M. MacAlpine,Gos Micklem,Fabio Piano,Michael Snyder,Lincoln Stein,Kevin P. White,Robert H. Waterston +15 more
TL;DR: This issue, modENCODE team members outline their plan of campaign and data from the project are to be made available on http://www.modencode.org and elsewhere as the work progresses.
Journal Article
Comprehensive analysis of the chromatin landscape in Drosophila melanogaster
Peter V. Kharchenko,Artyom A. Alekseyenko,Artyom A. Alekseyenko,Yuri B. Schwartz,Aki Minoda,Nicole C. Riddle,Jason Ernst,Jason Ernst,Peter J. Sabo,Erica Larschan,Erica Larschan,Erica Larschan,Andrey A. Gorchakov,Andrey A. Gorchakov,Tingting Gu,Daniela Linder-Basso,Annette Plachetka,Annette Plachetka,Gregory A. Shanower,Michael Y. Tolstorukov,Michael Y. Tolstorukov,Lovelace J. Luquette,Ruibin Xi,Youngsook L. Jung,Youngsook L. Jung,Richard W. Park,Richard W. Park,Eric P. Bishop,Eric P. Bishop,Theresa K. Canfield,Richard Sandstrom,Robert E. Thurman,David M. MacAlpine,John A. Stamatoyannopoulos,Manolis Kellis,Manolis Kellis,Sarah C. R. Elgin,Mitzi I. Kuroda,Mitzi I. Kuroda,Vincenzo Pirrotta,Gary H. Karpen,Peter J. Park,Peter J. Park,Peter J. Park +43 more
TL;DR: It is found that active genes display distinct chromatin signatures that are correlated with disparate gene lengths, exon patterns, regulatory functions and genomic contexts, and a diversity of signatures among Polycomb targets that include a subset with paused polymerase.
Journal ArticleDOI
Genome-wide probing of RNA structure reveals active unfolding of mRNA structures in vivo
TL;DR: In this article, the authors present an approach for globally monitoring RNA structure in native conditions in vivo with single-nucleotide precision, based on in vivo modification with dimethyl sulphate (DMS), which reacts with unpaired adenine and cytosine residues, followed by deep sequencing to monitor modifications.
Journal Article
Discovery and characterization of chromatin states for systematic annotation of the human genome
Jason Ernst,Manolis Kellis +1 more
TL;DR: In this article, a multivariate Hidden Markov Model was used to reveal chromatin states in human T cells, based on recurrent and spatially coherent combinations of chromatin marks.
Journal ArticleDOI
Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci.
Philip L. De Jager,Gyan Srivastava,Katie Lunnon,Jeremy D. Burgess,Leonard C. Schalkwyk,Lei Yu,Matthew L. Eaton,Brendan T. Keenan,Jason Ernst,Cristin McCabe,Anna Tang,Towfique Raj,Joseph M. Replogle,Wendy Brodeur,Stacey Gabriel,High Seng Chai,Curtis S. Younkin,Steven G. Younkin,Fanggeng Zou,Moshe Szyf,Charles B. Epstein,Julie A. Schneider,Bradley E. Bernstein,Alexander Meissner,Nilufer Ertekin-Taner,Lori B. Chibnik,Manolis Kellis,Jonathan Mill,David A. Bennett +28 more
TL;DR: The analyses suggest that DNA methylation changes may have a role in the onset of AD given that they were observed in presymptomatic subjects and that six of the validated genes connect to a known AD susceptibility gene network.