Manolis Kellis

TL;DR: The readthrough efficiency of the annotated stop codon for the sequence encoding vitamin D receptor (VDR), a member of the nuclear receptor superfamily of ligand-inducible transcription factors, was the highest of those tested but all showed notable levels of readthrough.

TL;DR: These analyses redefine the landscape of non-coding driver mutations in cancer genomes, confirming a few previously reported elements and raising doubts about others, while identifying novel candidate elements across 27 cancer types.

TL;DR: An in-depth investigation on the 2764 genes classified as coding by one or more sets of manual curators and not coding by others suggests that most are not under protein-like purifying selection and so are unlikely to code for functional proteins.

TL;DR: The implementation of longitudinal prospective studies to determine disease evolution and identify sub-clinical changes in response to exposures is proposed, which can help define critical windows of vulnerability and risk prediction and lead to identification of biomarkers of exposures and new modalities for therapeutic intervention.

TL;DR: In this article, an efficient algorithm for computing Pareto-optimal sets of reconciliations was proposed, thus providing the first systematic method for understanding the relationship between event costs and reconciliation.