Manolis Kellis

TL;DR: In this article, a high-confidence database of translated nuORFs across tissues (nuORFdb) was constructed and used to detect 3,555 translated unicast ORFs from MHC-I immunopeptidome mass spectrometry analysis.

TL;DR: In this article, the authors used deep-coverage whole genome sequencing in 8392 individuals of European and African ancestry to discover and interpret both single-nucleotide variants and copy number (CN) variation associated with Lp(a).

TL;DR: It is revealed that memory encoding leads to a genome-wide increase in chromatin accessibility, without expected changes in gene expression, and reactivation of the neurons during memory recall is associated with de novo promoter-enhancer interactions, utilizing a large subset of the enhancers that were primed during memory encoding.

TL;DR: The empirical results demonstrate that SubMAP can identify biologically relevant mappings that are missed by traditional alignment methods and is scalable for metabolic pathways of arbitrary topology, including searching for a query pathway of size 70 against the complete KEGG database of 1,842 pathways.

TL;DR: This analysis represents the first systematic investigation of the space of optimal DTL reconciliations and has many important implications for the study of gene family evolution.