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Mario Masellis
Researcher at Sunnybrook Health Sciences Centre
Publications - 290
Citations - 9815
Mario Masellis is an academic researcher from Sunnybrook Health Sciences Centre. The author has contributed to research in topics: Frontotemporal dementia & Medicine. The author has an hindex of 42, co-authored 212 publications receiving 6662 citations. Previous affiliations of Mario Masellis include Sunnybrook Research Institute & Centre for Addiction and Mental Health.
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Journal ArticleDOI
Blood–brain barrier opening in Alzheimer’s disease using MR-guided focused ultrasound
Nir Lipsman,Nir Lipsman,Ying Meng,Allison Bethune,Allison Bethune,Yuexi Huang,Benjamin Lam,Mario Masellis,Nathan Herrmann,Chinthaka Heyn,Isabelle Aubert,Isabelle Aubert,Alexandre Boutet,Gwenn S. Smith,Kullervo Hynynen,Kullervo Hynynen,Sandra E. Black +16 more
TL;DR: The results of this safety and feasibility study support the continued investigation of focused ultrasound as a potential novel treatment and delivery strategy for patients with Alzheimer’s disease and show that the procedure is safe.
Journal ArticleDOI
Presymptomatic cognitive and neuroanatomical changes in genetic frontotemporal dementia in the Genetic Frontotemporal dementia Initiative (GENFI) study: a cross-sectional analysis
Jonathan D. Rohrer,Jennifer M. Nicholas,Jennifer M. Nicholas,David M. Cash,John C. van Swieten,Elise G.P. Dopper,Lize C. Jiskoot,Rick van Minkelen,Serge A.R.B. Rombouts,M. Jorge Cardoso,Shona Clegg,Miklos Espak,Simon Mead,David L. Thomas,Enrico De Vita,Mario Masellis,Sandra E. Black,Morris Freedman,Ron Keren,Bradley J. MacIntosh,Ekaterina Rogaeva,David F. Tang-Wai,Maria Carmela Tartaglia,Robert Laforce,Fabrizio Tagliavini,Pietro Tiraboschi,Veronica Redaelli,Sara Prioni,Marina Grisoli,Barbara Borroni,Alessandro Padovani,Daniela Galimberti,Elio Scarpini,Andrea Arighi,Giorgio G. Fumagalli,James B. Rowe,Ian Coyle-Gilchrist,Caroline Graff,Caroline Graff,Marie Fallström,Vesna Jelic,Vesna Jelic,Anne Kinhult Ståhlbom,Anne Kinhult Ståhlbom,Christin Andersson,Christin Andersson,Håkan Thonberg,Håkan Thonberg,Lena Lilius,Giovanni B. Frisoni,Giuliano Binetti,Michela Pievani,Martina Bocchetta,Luisa Benussi,Roberta Ghidoni,Elizabeth Finger,Sandro Sorbi,Benedetta Nacmias,Gemma Lombardi,Cristina Polito,Jason D. Warren,Sebastien Ourselin,Nick C. Fox,Martin N. Rossor +63 more
TL;DR: Structural imaging and cognitive changes can be identified 5-10 years before expected onset of symptoms in asymptomatic adults at risk of genetic frontotemporal dementia, which could help to define biomarkers that can stage presymPTomatic disease and track disease progression.
Journal ArticleDOI
A Multicenter Study of Glucocerebrosidase Mutations in Dementia With Lewy Bodies
Mike A. Nalls,Raquel Duran,Grisel Lopez,Marzena Kurzawa-Akanbi,Ian G. McKeith,Patrick F. Chinnery,Christopher Morris,Jessie Theuns,Jessie Theuns,David Crosiers,David Crosiers,Patrick Cras,Sebastiaan Engelborghs,Peter Paul De Deyn,Christine Van Broeckhoven,Christine Van Broeckhoven,David M. A. Mann,Julie S. Snowden,Stuart Pickering-Brown,Nicola Halliwell,Yvonne S Davidson,Linda Gibbons,Jenny Harris,Una-Marie Sheerin,Jose Bras,John Hardy,Lorraine N. Clark,Karen Marder,Lawrence S. Honig,Daniela Berg,Walter Maetzler,Kathrin Brockmann,Thomas Gasser,Fabiana Novellino,Aldo Quattrone,Grazia Annesi,Elvira Valeria De Marco,Ekaterina Rogaeva,Mario Masellis,Mario Masellis,Sandra E. Black,Sandra E. Black,Juan M. Bilbao,Tatiana Foroud,Bernardino Ghetti,William C. Nichols,Nathan Pankratz,Glenda M. Halliday,Suzanne Lesage,Suzanne Lesage,Suzanne Lesage,Stephan Klebe,Alexandra Durr,Charles Duyckaerts,Charles Duyckaerts,Charles Duyckaerts,Alexis Brice,Benoit I. Giasson,John Q. Trojanowski,Howard I. Hurtig,Nahid Tayebi,Claudia Landazabal,Claudia Landazabal,Melanie A. Knight,Margaux F. Keller,Margaux F. Keller,Andrew B. Singleton,Tyra G. Wolfsberg,Ellen Sidransky +68 more
TL;DR: In this paper, the authors found a significant association between GBA1 mutation carrier status and DLB, with an odds ratio of 8.28 (95% CI, 4.78-14.88).
Journal ArticleDOI
Research criteria for the diagnosis of prodromal dementia with Lewy bodies
Ian G. McKeith,Tanis J. Ferman,Alan J. Thomas,Frédéric Blanc,Bradley F Boeve,Hiroshige Fujishiro,Kejal Kantarci,Cristina Muscio,John T. O'Brien,Ronald B. Postuma,Dag Aarsland,Clive Ballard,Laura Bonanni,Paul C. Donaghy,Murat Emre,James E. Galvin,Douglas Galasko,Jennifer G. Goldman,Stephen N. Gomperts,Lawrence S. Honig,Manabu Ikeda,James B. Leverenz,Simon J.G. Lewis,Karen Marder,Mario Masellis,David P. Salmon,John-Paul Taylor,Debby W. Tsuang,Zuzana Walker,Pietro Tiraboschi +29 more
TL;DR: This work proposes operationalized diagnostic criteria for probable and possible mild cognitive impairment with Lewy bodies, which are intended for use in research settings pending validation for Use in clinical practice and are compatible with current criteria for other prodromal neurodegenerative disorders including Alzheimer and Parkinson disease.
Journal ArticleDOI
Uncovering the heterogeneity and temporal complexity of neurodegenerative diseases with Subtype and Stage Inference
Alexandra L. Young,Razvan V. Marinescu,Neil P. Oxtoby,Martina Bocchetta,Keir Yong,Nicholas C. Firth,David M. Cash,David L. Thomas,Katrina M. Dick,Jorge Cardoso,Jorge Cardoso,John C. van Swieten,Barbara Borroni,Daniela Galimberti,Daniela Galimberti,Mario Masellis,Maria Carmela Tartaglia,James B. Rowe,Caroline Graff,Fabrizio Tagliavini,Giovanni B. Frisoni,Robert Laforce,Elizabeth Finger,Alexandre de Mendonça,Sandro Sorbi,Jason D. Warren,Sebastian J. Crutch,Nick C. Fox,Sebastien Ourselin,Jonathan M. Schott,Jonathan D. Rohrer,Daniel C. Alexander +31 more
TL;DR: A machine-learning technique—Subtype and Stage Inference (SuStaIn)—able to uncover data-driven disease phenotypes with distinct temporal progression patterns, from widely available cross-sectional patient studies is introduced, using two neurodegenerative disease cohorts.