Martin Golebiewski

TL;DR: It is shown that HDAC2 undergoes basal turnover by the ubiquitin–proteasome pathway, and poly‐ubiquitination and proteasomal degradation provide an isoenzyme‐selective mechanism for downregulation ofHDAC2.

TL;DR: Three ontologies created specifically to address the needs of the systems biology community are described, including the Systems Biology Ontology, which provides semantic information about the model components, and the Kinetic Simulation Algorithm Ontology and the Terminology for the Description of Dynamics, which categorizes dynamical features of the simulation results and general systems behavior.

TL;DR: SABIO-RK (http://sabio.h-its.org/) is a web-accessible database storing comprehensive information about biochemical reactions and their kinetic properties, supported by automated consistency checks.

TL;DR: The latest edition of the Systems Biology Markup Language (SBML) is reviewed, a format designed for this purpose that leverages two decades of SBML and a rich software ecosystem that transformed how systems biologists build and interact with models.

TL;DR: The Path2Models project has automatically generated mathematical models from pathway representations using a suite of freely available software, resulting in more than 140 000 freely available models.