R
Raja Sekhar Nirujogi
Researcher at University of Dundee
Publications - 44
Citations - 3157
Raja Sekhar Nirujogi is an academic researcher from University of Dundee. The author has contributed to research in topics: Phosphorylation & Kinase. The author has an hindex of 11, co-authored 35 publications receiving 2417 citations. Previous affiliations of Raja Sekhar Nirujogi include Pondicherry University & Johns Hopkins University School of Medicine.
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Journal ArticleDOI
A draft map of the human proteome
Min-Sik Kim,Sneha M. Pinto,Derese Getnet,Raja Sekhar Nirujogi,Srikanth S. Manda,Raghothama Chaerkady,Anil K. Madugundu,Dhanashree S. Kelkar,Ruth Isserlin,Shobhit Jain,Joji Kurian Thomas,Babylakshmi Muthusamy,Pamela Leal-Rojas,Pamela Leal-Rojas,Praveen Kumar,Nandini A. Sahasrabuddhe,Lavanya Balakrishnan,Jayshree Advani,Bijesh George,Santosh Renuse,Lakshmi Dhevi N. Selvan,Arun H. Patil,Vishalakshi Nanjappa,Aneesha Radhakrishnan,Samarjeet Prasad,Tejaswini Subbannayya,Rajesh Raju,Manish Kumar,Sreelakshmi K. Sreenivasamurthy,Arivusudar Marimuthu,Gajanan Sathe,Sandip Chavan,Keshava K. Datta,Yashwanth Subbannayya,Apeksha Sahu,Soujanya D. Yelamanchi,Savita Jayaram,Pavithra Rajagopalan,Jyoti Sharma,Krishna R Murthy,Nazia Syed,Renu Goel,Aafaque Ahmad Khan,Sartaj Ahmad,Gourav Dey,Keshav Mudgal,Aditi Chatterjee,Tai-Chung Huang,Jun Zhong,Xinyan Wu,Patrick G. Shaw,Donald Freed,Muhammad Saddiq Zahari,Kanchan K Mukherjee,Subramanian Shankar,Anita Mahadevan,Henry H N Lam,Chris J. Mitchell,Susarla K. Shankar,Parthasarathy Satishchandra,John T. Schroeder,Ravi Sirdeshmukh,Anirban Maitra,Steven D. Leach,Charles G. Drake,Marc K. Halushka,T. S. Keshava Prasad,Ralph H. Hruban,Candace L. Kerr,Candace L. Kerr,Gary D. Bader,Christine A. Iacobuzio-Donahue,Harsha Gowda,Akhilesh Pandey +73 more
TL;DR: A draft map of the human proteome is presented using high-resolution Fourier-transform mass spectrometry to discover a number of novel protein-coding regions, which includes translated pseudogenes, non-c coding RNAs and upstream open reading frames.
Journal ArticleDOI
Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis
Martin Steger,Federico Diez,Herschel S. Dhekne,Pawel Lis,Raja Sekhar Nirujogi,Ozge Karayel,Francesca Tonelli,Terina N. Martinez,Esben Lorentzen,Suzanne R. Pfeffer,Dario R. Alessi,Matthias Mann +11 more
TL;DR: The results implicate LRRK2 in primary ciliogenesis and suggest that Rab-mediated protein transport and/or signaling defects at cilia may contribute to L RRK2-dependent pathologies.
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Ubiquilin 2 modulates ALS/FTD-linked FUS–RNA complex dynamics and stress granule formation
Elizabeth J. Alexander,Amirhossein Ghanbari Niaki,Tao Zhang,Tao Zhang,Jaya Sarkar,Yang Liu,Raja Sekhar Nirujogi,Akhilesh Pandey,Sua Myong,Jiou Wang,Jiou Wang +10 more
TL;DR: A previously unrecognized role for UBQLN2 is identified in regulating the early stages of liquid–liquid phase separation by directly modulating the fluidity of protein–RNA complexes and the dynamics of SG formation.
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PPM1H phosphatase counteracts LRRK2 signaling by selectively dephosphorylating Rab proteins
Kerryn Berndsen,Pawel Lis,Wondwossen M Yeshaw,Paulina S. Wawro,Raja Sekhar Nirujogi,Melanie Wightman,Thomas Macartney,Mark Dorward,Axel Knebel,Francesca Tonelli,Suzanne R. Pfeffer,Dario R. Alessi +11 more
TL;DR: PPM1H acts as a key modulator of LRRK2 signaling by controlling dephosphorylation of Rab proteins, and could offer a new therapeutic approach to prevent or treat Parkinson’s disease.
Journal ArticleDOI
Activation of diverse signalling pathways by oncogenic PIK3CA mutations
Xinyan Wu,Santosh Renuse,Nandini A. Sahasrabuddhe,Muhammad Saddiq Zahari,Raghothama Chaerkady,Min-Sik Kim,Raja Sekhar Nirujogi,Morassa Mohseni,Praveen Kumar,Rajesh Raju,Jun Zhong,Jian Yang,Johnathan Neiswinger,Jun Seop Jeong,Robert H. Newman,Maureen A. Powers,B. L. Somani,Edward Gabrielson,Saraswati Sukumar,Vered Stearns,Jiang Qian,Heng Zhu,Bert Vogelstein,Ben Ho Park,Akhilesh Pandey +24 more
TL;DR: It is demonstrated that phosphorylation of cortactin by AKT1 is important for mutant PI3K enhanced cell migration and invasion through mutagenesis studies, and a quantitative and global approach is described for identifying mutation-specific signaling events and for discovering novel signaling molecules as readouts of pathway activation or potential therapeutic targets.