Raja Sekhar Nirujogi

TL;DR: A draft map of the human proteome is presented using high-resolution Fourier-transform mass spectrometry to discover a number of novel protein-coding regions, which includes translated pseudogenes, non-c coding RNAs and upstream open reading frames.

TL;DR: The results implicate LRRK2 in primary ciliogenesis and suggest that Rab-mediated protein transport and/or signaling defects at cilia may contribute to L RRK2-dependent pathologies.

TL;DR: A previously unrecognized role for UBQLN2 is identified in regulating the early stages of liquid–liquid phase separation by directly modulating the fluidity of protein–RNA complexes and the dynamics of SG formation.

TL;DR: PPM1H acts as a key modulator of LRRK2 signaling by controlling dephosphorylation of Rab proteins, and could offer a new therapeutic approach to prevent or treat Parkinson’s disease.

TL;DR: It is demonstrated that phosphorylation of cortactin by AKT1 is important for mutant PI3K enhanced cell migration and invasion through mutagenesis studies, and a quantitative and global approach is described for identifying mutation-specific signaling events and for discovering novel signaling molecules as readouts of pathway activation or potential therapeutic targets.