T
Terhi Peuralinna
Researcher at University of Helsinki
Publications - 20
Citations - 9038
Terhi Peuralinna is an academic researcher from University of Helsinki. The author has contributed to research in topics: Population & Genome-wide association study. The author has an hindex of 14, co-authored 20 publications receiving 8080 citations. Previous affiliations of Terhi Peuralinna include Helsinki University Central Hospital & National Institutes of Health.
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Journal ArticleDOI
α-Synuclein Locus Triplication Causes Parkinson's Disease
Andrew B. Singleton,Matthew J. Farrer,Joshua C. Johnson,Amanda Singleton,Stephen Hague,Jennifer M. Kachergus,Mary M. Hulihan,Terhi Peuralinna,Amalia Dutra,Robert L. Nussbaum,Sarah Lincoln,Anthony Crawley,Melissa Hanson,Demetrius M. Maraganore,Charles H. Adler,Mark R. Cookson,Manfred D. Muenter,Melisa J. Baptista,David Miller,J. Blancato,John Hardy,Katrina Gwinn-Hardy +21 more
TL;DR: In this article, the α-synuclein was identified as the major component of Lewy bodies, the pathological hallmark of Parkinson's disease, and of glial cell cytoplasmic inclusions.
Journal ArticleDOI
A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD
Alan E. Renton,Elisa Majounie,Adrian James Waite,Javier Simón-Sánchez,Javier Simón-Sánchez,Sara Rollinson,J. Raphael Gibbs,J. Raphael Gibbs,Jennifer C. Schymick,Hannu Laaksovirta,John C. van Swieten,John C. van Swieten,Liisa Myllykangas,Hannu Kalimo,Anders Paetau,Yevgeniya Abramzon,Anne M. Remes,Alice Kaganovich,Sonja W. Scholz,Sonja W. Scholz,Sonja W. Scholz,Jamie Duckworth,Jinhui Ding,Daniel W. Harmer,Dena G. Hernandez,Dena G. Hernandez,Janel O. Johnson,Janel O. Johnson,Kin Y. Mok,Mina Ryten,Danyah Trabzuni,Rita Guerreiro,Richard W. Orrell,James Neal,Alexandra Murray,J. P. Pearson,Iris E. Jansen,David Sondervan,Harro Seelaar,Derek J. Blake,Kate Young,Nicola Halliwell,Janis Bennion Callister,Greg Toulson,Anna Richardson,Alexander Gerhard,Julie S. Snowden,David M. A. Mann,David Neary,Mike A. Nalls,Terhi Peuralinna,Lilja Jansson,Veli-Matti Isoviita,Anna-Lotta Kaivorinne,Maarit Hölttä-Vuori,Elina Ikonen,Raimo Sulkava,Michael Benatar,Joanne Wuu,Adriano Chiò,Gabriella Restagno,Giuseppe Borghero,Mario Sabatelli,David Heckerman,Ekaterina Rogaeva,Lorne Zinman,Jeffrey D. Rothstein,Michael Sendtner,Carsten Drepper,Evan E. Eichler,Can Alkan,Ziedulla Abdullaev,Svetlana Pack,Amalia Dutra,Evgenia Pak,John Hardy,Andrew B. Singleton,Nigel Williams,Peter Heutink,Stuart Pickering-Brown,Huw R. Morris,Huw R. Morris,Huw R. Morris,Pentti J. Tienari,Bryan J. Traynor,Bryan J. Traynor +85 more
TL;DR: The chromosome 9p21 amyotrophic lateral sclerosis-frontotemporal dementia (ALS-FTD) locus contains one of the last major unidentified autosomal-dominant genes underlying these common neurodegenerative diseases, and a large hexanucleotide repeat expansion in the first intron of C9ORF72 is shown.
Journal ArticleDOI
Senile systemic amyloidosis affects 25% of the very aged and associates with genetic variation in alpha2-macroglobulin and tau: a population-based autopsy study
Maarit Tanskanen,Terhi Peuralinna,Tuomo Polvikoski,Irma-Leena Notkola,Raimo Sulkava,John Hardy,Andrew B. Singleton,Sari Kiuru-Enari,Anders Paetau,Pentti J. Tienari,Liisa Myllykangas +10 more
TL;DR: In this paper, the prevalence and risk factors for SSA in a Finnish autopsied population aged 85 or over, as part of the population-based Vantaa 85+ Autopsy Study (n = 256), were studied.
Journal ArticleDOI
Chromosome 9p21 in amyotrophic lateral sclerosis in Finland: a genome-wide association study.
Hannu Laaksovirta,Terhi Peuralinna,Jennifer C. Schymick,Sonja W. Scholz,Sonja W. Scholz,Shaoi-Lin Lai,Shaoi-Lin Lai,Liisa Myllykangas,Raimo Sulkava,Lilja Jansson,Dena G. Hernandez,J. Raphael Gibbs,Mike A. Nalls,David Heckerman,Pentti J. Tienari,Bryan J. Traynor,Bryan J. Traynor +16 more
TL;DR: The data suggest the presence of a founder mutation for chromosome 9p21-linked ALS in the Finnish population, and the overlap with the risk haplotype recently reported for frontotemporal dementia provides further evidence of a shared genetic cause for these two neurodegenerative diseases.
Journal ArticleDOI
Common genetic variation and susceptibility to partial epilepsies: a genome-wide association study
Dalia Kasperavičiūtė,Claudia B. Catarino,Erin L. Heinzen,Chantal Depondt,Gianpiero L. Cavalleri,Luis O. Caboclo,Sarah K. Tate,Jenny Jamnadas-Khoda,Krishna Chinthapalli,Lisa M. S. Clayton,Kevin V. Shianna,Rodney A. Radtke,Mohamad A. Mikati,William Gallentine,Aatif M. Husain,Saud Alhusaini,David Leppert,David Leppert,Lefkos T. Middleton,Lefkos T. Middleton,Rachel A. Gibson,Marvin Johnson,Paul M. Matthews,Paul M. Matthews,David A. Hosford,Kjell Heuser,Leslie Amos,Marcos Ortega,Dominik Zumsteg,Heinz Gregor Wieser,Bernhard J. Steinhoff,Günter Krämer,Jörg Hansen,Thomas Dorn,Anne-Mari Kantanen,Leif Gjerstad,Leif Gjerstad,Terhi Peuralinna,Dena G. Hernandez,Kai Eriksson,Reetta Kälviäinen,Colin P. Doherty,Nicholas W. Wood,Massimo Pandolfo,John S. Duncan,Josemir W. Sander,Norman Delanty,David Goldstein,Sanjay M. Sisodiya +48 more
TL;DR: It is shown that, at best, common genetic variation can only have a modest role in predisposition to the partial epilepsies when considered across syndromes in Europeans, and research efforts should also be directed towards identifying the multiple rare variants likely to account for at least part of the heritability of the partial seizures.