T
Thomas J. Cahill
Researcher at University of Oxford
Publications - 54
Citations - 5434
Thomas J. Cahill is an academic researcher from University of Oxford. The author has contributed to research in topics: Infective endocarditis & Medicine. The author has an hindex of 16, co-authored 47 publications receiving 1804 citations. Previous affiliations of Thomas J. Cahill include University College London & Wellcome Trust Centre for Human Genetics.
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Journal ArticleDOI
Global Burden of Cardiovascular Diseases and Risk Factors, 1990–2019: Update From the GBD 2019 Study
Gregory A. Roth,George A. Mensah,Catherine O. Johnson,Giovanni Addolorato,Enrico Ammirati,Larry M. Baddour,Noël C. Barengo,Andrea Beaton,Emelia J. Benjamin,Catherine P. Benziger,Aimé Bonny,Michael Brauer,Marianne Brodmann,Thomas J. Cahill,Jonathan R. Carapetis,Alberico L. Catapano,Sumeet S. Chugh,Leslie T. Cooper,Josef Coresh,Michael H. Criqui,Nicole K. DeCleene,Kim A. Eagle,Sophia Emmons-Bell,Valery L. Feigin,Joaquim Fernández-Solà,F. Gerry R. Fowkes,Emmanuela Gakidou,Scott M. Grundy,Feng J. He,George Howard,Frank B. Hu,Lesley A. Inker,Ganesan Karthikeyan,Nicholas J Kassebaum,Walter Koroshetz,Carl J. Lavie,Donald M. Lloyd-Jones,Hong Lu,Antonio Mirijello,Awoke Misganaw Temesgen,Ali H. Mokdad,Andrew E. Moran,Paul Muntner,Jagat Narula,Bruce Neal,Mpiko Ntsekhe,Glaucia Moraes de Oliveira,Catherine M Otto,Mayowa O. Owolabi,Michael Pratt,Sanjay Rajagopalan,Marissa B Reitsma,Antonio Luiz Pinho Ribeiro,Nancy A. Rigotti,Anthony Rodgers,Craig Sable,Saate S Shakil,Karen Sliwa-Hahnle,Benjamin A Stark,Johan Sundström,Patrick Timpel,Imad I. Tleyjeh,Marco Valgimigli,Theo Vos,Paul K. Whelton,Magdi H. Yacoub,Liesl Zühlke,Christopher J L Murray,Valentin Fuster +68 more
TL;DR: CVD burden continues its decades-long rise for almost all countries outside high-income countries, and alarmingly, the age-standardized rate of CVD has begun to rise in some locations where it was previously declining in high- income countries.
Journal ArticleDOI
Transcatheter aortic valve implantation vs. surgical aortic valve replacement for treatment of symptomatic severe aortic stenosis: an updated meta-analysis
George C.M. Siontis,Pavel Overtchouk,Thomas J. Cahill,Thomas Modine,Bernard Prendergast,Fabien Praz,Thomas Pilgrim,Tatjana Petrinic,Adriani Nikolakopoulou,Georgia Salanti,Lars Søndergaard,Subodh Verma,Peter Jüni,Stephan Windecker +13 more
TL;DR: Compared with SAVR, TAVI is associated with reduction in all-cause mortality and stroke up to 2 years irrespective of baseline surgical risk and type of THV system.
Journal ArticleDOI
Fumarate is cardioprotective via activation of the Nrf2 antioxidant pathway.
Houman Ashrafian,Gabor Czibik,Mohamed Bellahcene,Dunja Aksentijevic,Anthony C. Smith,Sarah J. Mitchell,Sarah J. Mitchell,Michael S. Dodd,Jennifer A. Kirwan,Jonathan J. Byrne,Christian Ludwig,Henrik Isackson,Arash Yavari,Nicolaj B. Støttrup,Hussain Contractor,Thomas J. Cahill,Natasha Sahgal,Daniel R. Ball,Rune Isak Dupont Birkler,Iain P. Hargreaves,Daniel A. Tennant,John M. Land,Craig A. Lygate,Mogens Johannsen,Rajesh K. Kharbanda,Stefan Neubauer,Charles Redwood,Rafael de Cabo,Ismayil Ahmet,Mark I. Talan,Ulrich L. Günther,Alan J. Robinson,Mark R. Viant,Patrick J. Pollard,Damian J. Tyler,Hugh Watkins +35 more
TL;DR: It is proposed that clinically established fumarate derivatives activate the Nrf2 pathway and are readily testable cytoprotective agents.
Journal ArticleDOI
Heart regeneration and repair after myocardial infarction: translational opportunities for novel therapeutics
TL;DR: Findings have revealed novel pathways that could be therapeutically targeted to stimulate repair following myocardial infarction and have provided lessons to guide future efforts towards heart regeneration through cellular reprogramming or cardiomyocyte transplantation.
Journal ArticleDOI
Macrophages directly contribute collagen to scar formation during zebrafish heart regeneration and mouse heart repair
Filipa C. Simões,Thomas J. Cahill,Amy Kenyon,Daria Gavriouchkina,Daria Gavriouchkina,Joaquim M. Vieira,Xin Sun,Daniela Pezzolla,Christophe Ravaud,Eva Masmanian,Michael Weinberger,Sarah Mayes,Madeleine E. Lemieux,Damien N. Barnette,Mala Gunadasa-Rohling,Ruth M. Williams,David R. Greaves,Le A. Trinh,Scott E. Fraser,Sarah L. Dallas,Robin P. Choudhury,Tatjana Sauka-Spengler,Paul R. Riley +22 more
TL;DR: An evolutionarily-conserved function of macrophages is identified that contributes directly to the forming post-injury scar through cell-autonomous deposition of collagen.