Todd R. Golub

TL;DR: This study examined a cell line derived from a low-grade cervical lesion and found that it contained episomal copies of an HPV-31 subtype, HPV-30b, at approximately 50 copies per cell, and observed the amplification of HPV- 31b genomes in distinct foci in the upper portion of the in vitro-stratified epithelium similar to that found in productive HPV infections in vivo.

TL;DR: Mouse chimeras generated with TEL-/- ES cells establish TEL as the first transcription factor required specifically for hematopoiesis within the bone marrow, as opposed to other sites of hematoietic activity during development.

TL;DR: A statistical methodology for estimating dataset size requirements for classifying microarray data using learning curves is introduced, based on fitting inverse power-law models to construct empirical learning curves.

TL;DR: DEMETER2, a hierarchical model coupled with model-based normalization, which allows the assessment of differential dependencies across genes and cell lines, is introduced, providing a unified resource representing the most extensive compilation of cancer cell line genetic dependencies to date.

TL;DR: Oligomerization of TEL/PDGFβR that is dependent on the TEL HLH domain provides further evidence that the HLHdomain, highly conserved among ETS family members, is a self-association motif.