Todd R. Golub

TL;DR: The results demonstrate that cyclin A1 is required for the proliferative effect of Six1, and conclude that Six1 overexpression reinstates an embryonic pathway of proliferation in breast cancer by up-regulating cyclIn A1.

TL;DR: The concept that acquired mutations in cancer may not contribute to malignant transformation and underscore the importance of functional studies to distinguish "driver" mutations underlying tumorigenesis from biologically neutral "passenger" alterations are supported.

TL;DR: It is shown that lung tumors initially respond to cisplatin by sensing DNA damage, undergoing cell cycle arrest, and inducing apoptosis-leading to a significant reduction in tumor burden, and a novel role for PIDD as a regulator of chemotherapy response in human lung tumor cells is demonstrated.

TL;DR: A unique bead-based strategy is developed for the identification of inducers of fetal hemoglobin transcripts in primary human erythroid cells and the potential of isoform-selective inhibitors of HDAC1 and HDAC2 for the treatment of sickle cell disease is suggested.

TL;DR: This investigation investigated whether a liver-derived 186-gene signature previously associated with outcomes of patients with HCC is prognostic for patients with newly diagnosed cirrhosis but without HCC, and whether this signature might be used to identify patients with Cirrhosis in most need of surveillance and strategies to prevent the development of HCC.