T
Todd R. Golub
Researcher at Harvard University
Publications - 454
Citations - 234100
Todd R. Golub is an academic researcher from Harvard University. The author has contributed to research in topics: Cancer & Gene expression profiling. The author has an hindex of 164, co-authored 422 publications receiving 201457 citations. Previous affiliations of Todd R. Golub include Rush University Medical Center & Boston Children's Hospital.
Papers
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Journal ArticleDOI
MLL-rearranged leukemias: insights from gene expression profiling.
TL;DR: Insights gained from characterization of MLL-rearranged human leukemias by genome-wide expression profiling are reviewed and compared to data from model systems.
Patent
Prostate cancer diagnosis and outcome prediction by expression analysis
TL;DR: In this paper, methods for identifying prostate cancer, methods for prognosing and diagnosing prostate cancer using oligonucleotide microarrays containing probes for genes involved in prostate cancer development, and methods for determining the efficacy of a prostate cancer therapy are described.
Journal ArticleDOI
Identification of an evolutionarily conserved transcriptional signature of CD8 memory differentiation that is shared by T and B cells.
W. Nicholas Haining,Benjamin L. Ebert,Benjamin L. Ebert,Benjamin L. Ebert,Aravind Subrmanian,E. John Wherry,Quentin Eichbaum,John W. Evans,Raymond H. Mak,Stephen Rivoli,Jennifer Pretz,Jill Angelosanto,John S. Smutko,Bruce D. Walker,Susan M. Kaech,Rafi Ahmed,Lee M. Nadler,Todd R. Golub,Todd R. Golub +18 more
TL;DR: The data suggest that in addition to lineage-specific differentiation programs, T and B lymphocytes use a common transcriptional program during memory development that is disrupted in chronic viral infection.
Journal ArticleDOI
microRNA Expression during Trophectoderm Specification
Srinivas R. Viswanathan,Craig H. Mermel,Jun Lu,Chi-Wei Lu,Todd R. Golub,Todd R. Golub,George Q. Daley +6 more
TL;DR: Compared in vitro and in vivo datasets are compared to identify a minimal set of candidate miRNAs likely to play a role in trophectoderm specification, predicted to regulate a host of development-associated target genes, and many of these mi RNAs have previously reported roles in development and differentiation.
Journal ArticleDOI
A Transcriptional Profiling Study of CCAAT/Enhancer Binding Protein Targets Identifies Hepatocyte Nuclear Factor 3β as a Novel Tumor Suppressor in Lung Cancer
Balazs Halmos,Daniela S. Basseres,Stefano Monti,Francesco D'Alo,Tajhal Dayaram,Katalin Ferenczi,Bas J. Wouters,Claudia S. Huettner,Todd R. Golub,Daniel G. Tenen +9 more
TL;DR: This is the first study to show genetic abnormalities of lung-specific differentiation pathways in the development of lung cancer by performing a transcriptional profiling study of C/EBPα target genes using an inducible cell line system.