T
Todd R. Golub
Researcher at Harvard University
Publications - 454
Citations - 234100
Todd R. Golub is an academic researcher from Harvard University. The author has contributed to research in topics: Cancer & Gene expression profiling. The author has an hindex of 164, co-authored 422 publications receiving 201457 citations. Previous affiliations of Todd R. Golub include Rush University Medical Center & Boston Children's Hospital.
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Journal ArticleDOI
Genetic and transcriptional evolution alters cancer cell line drug response
Uri Ben-David,Benjamin A. Siranosian,Gavin Ha,Gavin Ha,Helen Tang,Yaara Oren,Yaara Oren,Kunihiko Hinohara,Kunihiko Hinohara,Craig A. Strathdee,Joshua M. Dempster,Nicholas J. Lyons,Robert Burns,Anwesha Nag,Guillaume Kugener,Beth A. Cimini,Peter Tsvetkov,Yosef E. Maruvka,Ryan O’Rourke,Ryan O’Rourke,Anthony J. Garrity,Andrew A. Tubelli,Pratiti Bandopadhayay,Pratiti Bandopadhayay,Aviad Tsherniak,Francisca Vazquez,Bang Wong,Chet Birger,Mahmoud Ghandi,Aaron R. Thorner,Joshua A. Bittker,Matthew Meyerson,Matthew Meyerson,Gad Getz,Gad Getz,Rameen Beroukhim,Todd R. Golub +36 more
TL;DR: The extent, origins and consequences of genetic variation within human cell lines are studied, providing a framework for researchers to measure such variation in efforts to support maximally reproducible cancer research.
Exome and whole-genome sequencing of esophageal adenocarcinoma identifies recurrent driver events and mutational complexity
Austin M. Dulak,Petar Stojanov,Petar Stojanov,Petar Stojanov,Shouyong Peng,Shouyong Peng,Michael S. Lawrence,Cameron Fox,Chip Stewart,Santhoshi Bandla,Yu Imamura,Steven E. Schumacher,Steven E. Schumacher,Erica Shefler,Aaron McKenna,Scott L. Carter,Kristian Cibulskis,Andrey Sivachenko,Gordon Saksena,Douglas Voet,Alex H. Ramos,Daniel Auclair,Kristin Thompson,Carrie Sougnez,Robert C. Onofrio,Candace Guiducci,Rameen Beroukhim,Zhongren Zhou,Lin Lin,Jules Lin,Rishindra M. Reddy,Andrew C. Chang,Rodney Landrenau,Arjun Pennathur,Shuji Ogino,James D. Luketich,Todd R. Golub,Stacey Gabriel,Eric S. Lander,Eric S. Lander,Eric S. Lander,David G. Beer,Tony E. Godfrey,Gad Getz,Gad Getz,Adam J. Bass +45 more
TL;DR: A mutational signature defined by a high prevalence of A>C transversions at AA dinucleotides is identified and the potential activation of the RAC1 pathway is suggested as a contributor to EAC tumorigenesis.
Journal ArticleDOI
Highly parallel identification of essential genes in cancer cells
Biao Luo,Hiu Wing Cheung,Aravind Subramanian,Tanaz Sharifnia,Michael Okamoto,Xiaoping Yang,Greg Hinkle,Jesse S. Boehm,Rameen Beroukhim,Barbara A. Weir,Craig H. Mermel,David A. Barbie,Tarif Awad,Xiaochuan Zhou,Tuyen T. Nguyen,Bruno Piqani,Cheng Li,Todd R. Golub,Matthew Meyerson,Nir Hacohen,William C. Hahn,Eric S. Lander,David M. Sabatini,David E. Root +23 more
TL;DR: An efficient, robust approach to perform genome-scale pooled shRNA screens for both positive and negative selection and its application to systematically identify cell essential genes in 12 cancer cell lines is reported.
Journal ArticleDOI
Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulators
Haley Hieronymus,Justin Lamb,Kenneth N. Ross,Xiao P. Peng,Xiao P. Peng,Cristina C. Clement,Anna Rodina,Maria Nieto,Jinyan Du,Kimberly Stegmaier,Srilakshmi M. Raj,Srilakshmi M. Raj,Katherine N. Maloney,Jon Clardy,William C. Hahn,William C. Hahn,Gabriela Chiosis,Todd R. Golub,Todd R. Golub,Todd R. Golub +19 more
TL;DR: This work identifies new modes of HSP90 modulation through a gene expression-based strategy that is similar to celastrol and gedunin and blocks the ability of androgen receptor (AR) signaling states to be modulated.
Journal ArticleDOI
Decoupling genetics, lineages, and microenvironment in IDH-mutant gliomas by single-cell RNA-seq
Andrew S. Venteicher,Andrew S. Venteicher,Itay Tirosh,Christine Hebert,Christine Hebert,Keren Yizhak,Keren Yizhak,Cyril Neftel,Cyril Neftel,Cyril Neftel,Mariella G. Filbin,Mariella G. Filbin,Volker Hovestadt,Volker Hovestadt,Leah E. Escalante,Leah E. Escalante,McKenzie Shaw,McKenzie Shaw,Christopher Rodman,Shawn M. Gillespie,Danielle Dionne,Christina C. Luo,Hiranmayi Ravichandran,Ravindra Mylvaganam,Christopher Mount,Maristela L. Onozato,Brian V. Nahed,Hiroaki Wakimoto,William T. Curry,A. John Iafrate,Miguel Rivera,Miguel Rivera,Matthew P. Frosch,Todd R. Golub,Todd R. Golub,Todd R. Golub,Priscilla K. Brastianos,Gad Getz,Gad Getz,Anoop P. Patel,Michelle Monje,Daniel P. Cahill,Orit Rozenblatt-Rosen,David N. Louis,Bradley E. Bernstein,Bradley E. Bernstein,Aviv Regev,Aviv Regev,Aviv Regev,Mario L. Suvà,Mario L. Suvà +50 more
TL;DR: This approach provides a general framework to decipher differences between classes of human tumors by decoupling cancer cell genotypes, phenotypes, and the composition of the TME.