T
Todd R. Golub
Researcher at Harvard University
Publications - 454
Citations - 234100
Todd R. Golub is an academic researcher from Harvard University. The author has contributed to research in topics: Cancer & Gene expression profiling. The author has an hindex of 164, co-authored 422 publications receiving 201457 citations. Previous affiliations of Todd R. Golub include Rush University Medical Center & Boston Children's Hospital.
Papers
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Journal ArticleDOI
An Analytical Method for Multiclass Molecular Cancer Classification
Ryan Rifkin,Sayan Mukherjee,Pablo Tamayo,Sridhar Ramaswamy,Chen-Hsiang Yeang,Michael Angelo,Michael R. Reich,Tomaso Poggio,Eric S. Lander,Todd R. Golub,Jill P. Mesirov +10 more
TL;DR: In this paper, a computational methodology for multiclass prediction that combines class-specific (one vs. all) binary support vector machines was proposed for the diagnosis of multiple common adult malignancies using DNA microarray data.
Journal ArticleDOI
Noncanonical open reading frames encode functional proteins essential for cancer cell survival
John R. Prensner,John R. Prensner,John R. Prensner,Oana M. Enache,Victor Luria,Karsten Krug,Karl R. Clauser,Joshua M. Dempster,Amir Karger,Li Wang,Karolina Stumbraite,Vickie M. Wang,Ginevra Botta,Nicholas J. Lyons,Amy Goodale,Zohra Kalani,Briana Fritchman,Adam Brown,Douglas Alan,Thomas M Green,Xiaoping Yang,Jacob D. Jaffe,Jennifer Roth,Federica Piccioni,Federica Piccioni,Marc W. Kirschner,Zhe Ji,David E. Root,Todd R. Golub,Todd R. Golub,Todd R. Golub +30 more
TL;DR: This article showed that non-canonical open reading frames (ORFs) can express biologically active proteins that are potential therapeutic targets, such as glycine-rich extracellular protein-1 (GREP1), which is highly expressed in breast cancer.
Journal Article
In vitro differentiation of epithelial cells from cervical neoplasias resembles in vivo lesions.
TL;DR: It is shown that in the raft system, cultured cells derived from tissue biopsies can duplicate many of the histological features observed in cervical neoplasias and will thus be useful for examining the effects of HPV infection on epithelial maturation and for investigating the role of other factors in the progression of cervical malignancies.
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An ecosystem of cancer cell line factories to support a cancer dependency map.
Jesse S. Boehm,Todd R. Golub +1 more
TL;DR: An international effort to establish >10,000 cancer cell line models as a community resource will facilitate the creation of a cancer dependency map, connecting cancer genomics to therapeutic dependencies.
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The microRNA miR-31 inhibits CD8+ T cell function in chronic viral infection
Howell F. Moffett,Adam N.R. Cartwright,Hye-Jung Kim,Jernej Godec,Jason Pyrdol,Tarmo Äijö,Gustavo J. Martinez,Anjana Rao,Jun Lu,Todd R. Golub,Harvey Cantor,Arlene H. Sharpe,Carl D. Novina,Kai W. Wucherpfennig +13 more
TL;DR: Mechanistically, miR-31 increased the sensitivity of T cells to type I interferons, which interfered with effector T cell function and increased the expression of several proteins related to T cell dysfunction during chronic infection.