T
Todd R. Golub
Researcher at Harvard University
Publications - 454
Citations - 234100
Todd R. Golub is an academic researcher from Harvard University. The author has contributed to research in topics: Cancer & Gene expression profiling. The author has an hindex of 164, co-authored 422 publications receiving 201457 citations. Previous affiliations of Todd R. Golub include Rush University Medical Center & Boston Children's Hospital.
Papers
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Journal ArticleDOI
HOXA9 Is a Novel Therapeutic Target in Multiple Myeloma.
Michael A Chapman,Jean-Philippe Brunet,Jonathan J Keats,Angela Baker,Mazhar Adli,Anna C. Schinzel,Gregory J. Ahmann,Harview Christina,Anna Moore,Vijayalakshmi Shanmugam,Louise M. Perkins,Daniel Auclair,William C. Hahn,Bradley E. Bernstein,Leif Bergsagel,Rafael Fonseca,John D. Carpten,Jeffrey M. Trent,Todd R. Golub +18 more
TL;DR: In this article, HOXA9 expression was found to be essential for survival of multiple myeloma (MM) cells, and the authors used an outlier statistical approach to identify the top candidate gene for further investigation.
Proceedings ArticleDOI
Abstract 4017: Dissecting the clonal hierarchy of cancer-driving genomic lesions.
Davide Prandi,Sylvan C. Baca,Michael S. Lawrence,Juan Miguel Mosquera,Alessandro Romanel,Yotam Drier,Kyung Park,Naoki Kitabayashi,Theresa Y. MacDonald,Eliezer M. Van Allen,Gregory V. Kryukov,Jean-Philippe Theurillat,David Soong,Elizabeth Nickerson,Daniel Auclair,Ashutosh K. Tewari,Himisha Beltran,Robert C. Onofrio,Gunther Boysen,Candace Guiducci,Christopher E. Barbieri,Kristian Cibulskis,Andrey Sivachenko,Scott L. Carter,Gordon Saksena,Douglas Voet,Alex H. Ramos,Wendy Winckler,Michelle Cipicchio,Kristin G. Ardlie,Philip W. Kantoff,Michael F. Berger,Stacey Gabriel,Todd R. Golub,Matthew Meyerson,Eric S. Lander,Olivier Elemento,Gad Getz,Francesca Demichelis,Mark A. Rubin,Levi A. Garraway +40 more
TL;DR: The results imply the existence of consensus paths of tumor carcinogenesis that favor dysregulation of cancer genes in a defined sequence.
Patent
Compounds and methods for targeting leukemic stem cells
Kimberly A. Hartwell,Malcolm A.S. Moore,David T. Scadden,Stuart L. Schreiber,Todd R. Golub,Benito Munoz,Benjamin L. Ebert,Andrew M. Stern,Peter Grant Miller,D. Gary Gilliland,Anne Carpenter Van Dyk,David J. Logan,Joseph Negri,Nicola Tolliday,Alykhan F. Shamji,Siddhartha Mukherjee,Alison L. Stewart +16 more
TL;DR: In this article, a semi-automated method for identifying compounds that are effective in targeting leukemia stem cells, as well as compounds identified by those methods and uses thereof for treating leukemia.
Journal ArticleDOI
The Somatic Cancer Genome
TL;DR: Efforts to pilot such a “Target Accelerator” will be presented, with particular emphasis on use of the Connectivity Map/Library of integrated cellular signatures (LINCS) resource to systematically connect mutant alleles to pathways and to potential therapeutic strategies.
Proceedings ArticleDOI
Abstract 993: Whole exome sequencing of CTCs as a window into metastatic cancer
Viktor A. Adalsteinsson,Jens G. Lohr,Kristian Cibulskis,Atish D. Choudhury,Mara Rosenberg,Peter Cruz-Gordillo,Joshua M. Francis,Cheng-Zhong Zhang,Alex K. Shalek,Rahul Satija,John T. Trombetta,Diana Lu,Naren Tallapragada,Narmin Tahirova,Sora Kim,Brendan Blumenstiel,Carrie Sougnez,Daniel Auclair,Eliezer M. Van Allen,Mari Nakabayashi,Rosina T. Lis,Gwo-Shu Mary Lee,Tiantian Li,Matthew S. Chabot,Mary-Ellen Taplin,Thomas E. Clancy,Massimo Loda,Aviv Regev,Matthew Meyerson,William C. Hahn,Philip W. Kantoff,Todd R. Golub,Gad Getz,Jesse S. Boehm,J. Christopher Love +34 more
TL;DR: The feasibility of CTC sequencing and the ability to confidently call somatic mutations are demonstrated, and CTCs may represent a non-invasive window into the mutational landscape of metastatic cancer, and may have utility for genomics in clinical practice.