Todd R. Golub

TL;DR: This work shows that mitigating off-target effects is feasible in these datasets via computational methodologies to produce a consensus gene signature (CGS) and compared RNAi technology to clustered regularly interspaced short palindromic repeat (CRISPR)-based knockout by analysis of 373 single guide RNAs (sgRNAs) to show that the on-target efficacies are comparable, but CRISPR technology is far less susceptible to systematic off- target effects.

TL;DR: An early endoderm gene expression signature is developed, and transcriptional similarities and differences between definitive and visceral endODerm are clarified, and methods for flow cytometric isolation of definitive and abdominal endoderman are developed.

TL;DR: Pooled in vivo screen and gene expression profiling identified functional variants and demonstrated that expression of rare variants induced tumorigenesis, underscoring the value of integrating genomic information with functional studies.

TL;DR: In this paper, methods and apparatus for classifying or predicting the classes for samples based on gene expression are described, as well as methods and methods for ascertaining or discovering new, previously unknown classes.

TL;DR: The findings of microarray studies are beginning to enter clinical practice as novel diagnostic tests, and clinical trials are ongoing in which therapeutic agents are being used to target pathways that were identified by gene expression profiling.