T
Todd R. Golub
Researcher at Harvard University
Publications - 454
Citations - 234100
Todd R. Golub is an academic researcher from Harvard University. The author has contributed to research in topics: Cancer & Gene expression profiling. The author has an hindex of 164, co-authored 422 publications receiving 201457 citations. Previous affiliations of Todd R. Golub include Rush University Medical Center & Boston Children's Hospital.
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Initial genome sequencing and analysis of multiple myeloma
Michael A Chapman,Michael S. Lawrence,Jonathan J Keats,Kristian Cibulskis,Carrie Sougnez,Anna C. Schinzel,Christina L. Harview,Jean Philippe Brunet,Gregory J. Ahmann,Mazhar Adli,Mazhar Adli,Kenneth C. Anderson,Kristin G. Ardlie,Daniel Auclair,Angela Baker,P. Leif Bergsagel,Bradley E. Bernstein,Bradley E. Bernstein,Bradley E. Bernstein,Yotam Drier,Yotam Drier,Rafael Fonseca,Stacey Gabriel,Craig C. Hofmeister,Sundar Jagannath,Andrzej Jakubowiak,Amrita Krishnan,Joan Levy,Ted Liefeld,Sagar Lonial,Scott Mahan,Bunmi Mfuko,Stefano Monti,Louise M. Perkins,Robb Onofrio,Trevor J. Pugh,S. Vincent Rajkumar,Alex H. Ramos,David S. Siegel,Andrey Sivachenko,A. Keith Stewart,Suzanne Trudel,Ravi Vij,Douglas Voet,Wendy Winckler,Todd Zimmerman,John D. Carpten,Jeff Trent,William C. Hahn,William C. Hahn,Levi A. Garraway,Levi A. Garraway,Matthew Meyerson,Matthew Meyerson,Eric S. Lander,Eric S. Lander,Eric S. Lander,Gad Getz,Todd R. Golub +58 more
TL;DR: In this paper, a massively parallel sequencing of 38 tumour genomes and their comparison to matched normal DNAs was reported, and several new and unexpected oncogenic mechanisms were suggested by the pattern of somatic mutation across the data set.
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Sequence analysis of mutations and translocations across breast cancer subtypes
Shantanu Banerji,Kristian Cibulskis,Claudia Rangel-Escareño,Kristin K. Brown,Scott L. Carter,Abbie M. Frederick,Michael S. Lawrence,Andrey Sivachenko,Carrie Sougnez,Lihua Zou,Maria L. Cortes,Juan Carlos Fernández-López,Shouyong Peng,Kristin G. Ardlie,Daniel Auclair,Verónica Bautista-Piña,Fujiko Duke,Joshua M. Francis,Joonil Jung,Antonio Maffuz-Aziz,Robert C. Onofrio,Melissa Parkin,Nam Pho,Valeria Quintanar-Jurado,Alex H. Ramos,Rosa Rebollar-Vega,Sergio Rodriguez-Cuevas,Sandra Romero-Cordoba,Steven E. Schumacher,Steven E. Schumacher,Nicolas Stransky,Kristin Thompson,Laura Uribe-Figueroa,José Baselga,Rameen Beroukhim,Rameen Beroukhim,Kornelia Polyak,Dennis C. Sgroi,Andrea L. Richardson,Gerardo Jimenez-Sanchez,Eric S. Lander,Eric S. Lander,Eric S. Lander,Stacey Gabriel,Levi A. Garraway,Levi A. Garraway,Todd R. Golub,Jorge Melendez-Zajgla,Alex Toker,Gad Getz,Alfredo Hidalgo-Miranda,Matthew Meyerson,Matthew Meyerson +52 more
TL;DR: Recurrent somatic mutations in PIK3CA, TP53, AKT1, GATA3 and MAP3K1 are confirmed and a recurrent MAGI3–AKT3 fusion enriched in triple-negative breast cancer lacking oestrogen and progesterone receptors and ERBB2 expression is identified.
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Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes
Bjoern Chapuy,Chip Stewart,Andrew Dunford,Jaegil Kim,Atanas Kamburov,Robert A. Redd,Michael S. Lawrence,Michael S. Lawrence,Margaretha G.M. Roemer,Amy Li,Marita Ziepert,Annette M. Staiger,Annette M. Staiger,Jeremiah Wala,Matthew D. Ducar,Ignaty Leshchiner,Ester Rheinbay,Amaro Taylor-Weiner,Caroline A. Coughlin,Julian M. Hess,Chandra Sekhar Pedamallu,Dimitri Livitz,Daniel Rosebrock,Mara Rosenberg,Adam Tracy,Heike Horn,Paul Van Hummelen,Andrew L. Feldman,Brian K. Link,Anne J. Novak,James R. Cerhan,Thomas M. Habermann,Reiner Siebert,Andreas Rosenwald,Aaron R. Thorner,Matthew Meyerson,Matthew Meyerson,Todd R. Golub,Todd R. Golub,Rameen Beroukhim,Rameen Beroukhim,Gerald Wulf,German Ott,Scott J. Rodig,Scott J. Rodig,Stefano Monti,Donna Neuberg,Markus Loeffler,Michael Pfreundschuh,Lorenz Trümper,Gad Getz,Gad Getz,Margaret A. Shipp +52 more
TL;DR: A comprehensive genetic analysis of 304 primary DLBCLs identified low-frequency alterations, captured recurrent mutations, somatic copy number alterations, and structural variants, and defined coordinate signatures in patients with available outcome data to provide a roadmap for an actionableDLBCL classification.
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Integrative analysis reveals selective 9p24.1 amplification, increased PD-1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal large B-cell lymphoma
Michael R. Green,Stefano Monti,Scott J. Rodig,Przemyslaw Juszczynski,Treeve Currie,Evan O'Donnell,Bjoern Chapuy,Kunihiko Takeyama,Donna Neuberg,Todd R. Golub,Jeffery L. Kutok,Margaret A. Shipp +11 more
TL;DR: High-resolution copy number data with transcriptional profiles are integrated and identified the immunoregulatory genes, PD-L1 andPD-L2, as key targets at the 9p24.1 amplification peak in HL and MLBCL cell lines, defining the PD-1 pathway and JAK2 as complementary rational therapeutic targets.
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Increased Expression of Genes Converting Adrenal Androgens to Testosterone in Androgen-Independent Prostate Cancer
Michael Stanbrough,Glenn J. Bubley,Kenneth N. Ross,Todd R. Golub,Mark A. Rubin,Trevor M. Penning,Phillip G. Febbo,Steven P. Balk +7 more
TL;DR: Enhanced intracellular conversion of adrenal androgens to testosterone and dihydrotestosterone is a mechanism by which prostate cancer cells adapt to androgen deprivation and suggest new therapeutic targets.