T
Todd R. Golub
Researcher at Harvard University
Publications - 454
Citations - 234100
Todd R. Golub is an academic researcher from Harvard University. The author has contributed to research in topics: Cancer & Gene expression profiling. The author has an hindex of 164, co-authored 422 publications receiving 201457 citations. Previous affiliations of Todd R. Golub include Rush University Medical Center & Boston Children's Hospital.
Papers
More filters
Journal ArticleDOI
Duplex-Repair enables highly accurate sequencing, despite DNA damage.
Kan Xiong,Douglas Shea,Justin Rhoades,Timothy Blewett,Ruolin Liu,Jin H. Bae,Erica Nguyen,G. Mike Makrigiorgos,G. Mike Makrigiorgos,Todd R. Golub,Todd R. Golub,Viktor A. Adalsteinsson +11 more
TL;DR: Duplex-Repair as discussed by the authors limits interior duplex base pair resynthesis by 8- to 464-fold, rescues the impact of induced DNA damage, and affords up to 8.9-fold more accurate duplex sequencing.
Posted ContentDOI
Partial gene suppression improves identification of cancer vulnerabilities when CRISPR-Cas9 knockout is pan-lethal
John M. Krill-Burger,Joshua M. Dempster,Ashir A. Borah,Brenton R. Paolella,David E. Root,Todd R. Golub,Jesse S. Boehm,William C. Hahn,James M. McFarland,Francisca Vazquez,A. Tsherniak +10 more
TL;DR: It is found that CRISPR screens identify more dependencies, and yield more accurate predictive models and co-dependency relationships overall, and RNAi outperforms CRISpr in identifying associations with genes that are common dependencies for most cell lines (pan-dependencies).
Patent
Classification of samples, and identification of unknown class
TL;DR: In this article, the authors proposed a method for identifying unknown classes based on gene expression by sorting genes depending on a degree of their expression in a sample correlating to the class identification, determining whether the correlation is stronger than that which can be obtained by an accident, and identifying a set of genes.
Discovery of Inhibitors of Anti-Apoptotic Protein A1
Joshua A. Bittker,Michel Weïwer,Guo Wei,Andrew R. Germain,Emily J. Brown,Sivaraman Dandapani,Benito Munoz,Michelle Palmer,Todd R. Golub,Stuart L. Schreiber +9 more
Journal ArticleDOI
CXCR4 pathway associated with family history of melanoma
Wen-Qing Li,Jiali Han,Hans R. Widlund,Mick Correll,Yaoyu E. Wang,John Quackenbush,Martin C. Mihm,Alvaro Laga Canales,Shaowei Wu,Todd R. Golub,Yujin Hoshida,David J. Hunter,George F. Murphy,Thomas S. Kupper,Abrar A. Qureshi +14 more
TL;DR: It is found that the CXCR4 pathway might constitute a novel susceptibility pathway associated with family history of melanoma in first-degree relatives.