T
Todd R. Golub
Researcher at Harvard University
Publications - 454
Citations - 234100
Todd R. Golub is an academic researcher from Harvard University. The author has contributed to research in topics: Cancer & Gene expression profiling. The author has an hindex of 164, co-authored 422 publications receiving 201457 citations. Previous affiliations of Todd R. Golub include Rush University Medical Center & Boston Children's Hospital.
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Journal ArticleDOI
Id1 is a common downstream target of oncogenic tyrosine kinases in leukemic cells.
Winnie F. Tam,Winnie F. Tam,Winnie F. Tam,Ting-Lei Gu,Ting-Lei Gu,Jing Chen,Jing Chen,Benjamin H. Lee,Benjamin H. Lee,Lars Bullinger,Stefan Fröhling,Andrew Z. Wang,Stefano Monti,Todd R. Golub,Todd R. Golub,D. Gary Gilliland,D. Gary Gilliland,D. Gary Gilliland +17 more
TL;DR: It is indicated that inhibitor of DNA binding 1 (Id1), a gene involved in development, cell cycle, and tumorigenesis, is an important target of constitutively activated tyrosine kinases and may be a therapeutic target for leukemias associated with oncogenic tyrosines.
Journal ArticleDOI
Genetic modifiers of EGFR dependence in non-small cell lung cancer
Tanaz Sharifnia,Victor Rusu,Federica Piccioni,Mukta Bagul,Marcin Imielinski,Andrew D. Cherniack,Chandra Sekhar Pedamallu,Bang Wong,Frederick H. Wilson,Levi A. Garraway,David Altshuler,Todd R. Golub,David E. Root,Aravind Subramanian,Matthew Meyerson +14 more
TL;DR: A spectrum of kinase genes whose overexpression can overcome NSCLC cells’ reliance on EGFR are identified and their convergence on the PI3K-AKT and MEK-ERK signaling axes in sustaining EGFR-independent survival is underscored.
Journal ArticleDOI
Signatures of murine B-cell development implicate Yy1 as a regulator of the germinal center-specific program
Michael R. Green,Stefano Monti,Riccardo Dalla-Favera,Laura Pasqualucci,Nicole C. Walsh,Marc Schmidt-Supprian,Jeffery L. Kutok,Scott J. Rodig,Donna Neuberg,Klaus Rajewsky,Todd R. Golub,Frederick W. Alt,Frederick W. Alt,Margaret A. Shipp,John P. Manis +14 more
TL;DR: To elucidate transcription factor activities that function in a stage-specific fashion, gene sets that share transcription factor targets are used and it is found that germinal center B cells had a robust enrichment of up-regulated and down-regulated signatures compared with the other B-cell subsets.
Densely Interconnected Transcriptional Circuits Control Cell States in Human Hematopoiesis
Noa Novershtern,Noa Novershtern,Noa Novershtern,Aravind Subramanian,Lee N. Lawton,Raymond H. Mak,W. Nicholas Haining,Marie McConkey,Naomi Habib,Nir Yosef,Cindy Y. Chang,Cindy Y. Chang,Tal Shay,Garrett M. Frampton,Adam Drake,Ilya B. Leskov,Björn Nilsson,Björn Nilsson,Fred Preffer,David Dombkowski,John W. Evans,Ted Liefeld,John S. Smutko,Jianzhu Chen,Nir Friedman,Richard A. Young,Todd R. Golub,Todd R. Golub,Todd R. Golub,Aviv Regev,Aviv Regev,Aviv Regev,Benjamin L. Ebert,Benjamin L. Ebert,Benjamin L. Ebert +34 more
TL;DR: This work profiled gene expression in 38 distinct purified populations of human hematopoietic cells and used probabilistic models of gene expression and analysis of cis-elements in gene promoters to decipher the general organization of their regulatory circuitry.
Book ChapterDOI
The TEL Gene Contributes to the Pathogenesis of Myeloid and Lymphoid Leukemias by Diverse Molecular Genetic Mechanisms
TL;DR: The diverse molecular genetic mechanisms of leukemogenesis mediated by the TEL gene will be discussed and recent evidence suggests that loss of function of TEL may also contribute to pathogenesis of malignancy.