T
Todd R. Golub
Researcher at Harvard University
Publications - 454
Citations - 234100
Todd R. Golub is an academic researcher from Harvard University. The author has contributed to research in topics: Cancer & Gene expression profiling. The author has an hindex of 164, co-authored 422 publications receiving 201457 citations. Previous affiliations of Todd R. Golub include Rush University Medical Center & Boston Children's Hospital.
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Journal ArticleDOI
Modulating AML1-ETO with Signature-Based Small Molecule Library Screening.
TL;DR: This approach uses gene expression signatures as surrogates for different biological states in a small molecule library screen and determined that all five compounds induce both whole genome effects consistent with AML1-ETO knockdown and a whole genome program consistent with neutrophil maturation.
Proceedings ArticleDOI
Abstract P1-05-13: The metastatic breast cancer project: Translational genomics through direct patient engagement
Corrie A. Painter,Elana Anastasio,M Krevalin,Dewey Kim,K Larken,Niall Lennon,Elizabeth S. Frank,EP Winer,Eric S. Lander,Todd R. Golub +9 more
TL;DR: Remote acquisition of medical records, saliva samples, and tumor tissue for patients located throughout the U.S. is feasible and allows for rapid identification of patients with rare phenotypes such as extraordinary responders, who have been challenging to identify with traditional approaches.
Journal ArticleDOI
Mir-15a/16-1 Cluster Is Frequently Deleted In Primary Hodgkin Lymphoma and Modulates Multiple Survival Pathways Including AP-1
Bjoern Chapuy,Michael R. Green,Jun Lu,Stefano Monti,Yansheng Hao,Kelly T. Yeda,Scott J. Rodig,Treeve Currie,Kunihiko Takeyama,Todd R. Golub,Jeffery L. Kutok,Margaret A. Shipp +11 more
TL;DR: In this article, microRNA (miR) expression profiles were integrated with high-resolution copy number data and identified single copy loss of the miR-15a/16-1 locus (chromosome 13q14) and decreased miR 15a/ 16-1 expression in 75% of examined HL cell lines.
Proceedings ArticleDOI
Abstract 2352: Defining a pediatric cancer dependency map
Neekesh V. Dharia,Clare F. Malone,Amanda Balboni Iniguez,Lillian M. Guenther,Liying Chen,Gabriela Alexe,Adam D. Durbin,Mark W. Zimmerman,Andrew L. Hong,Pratiti Bandopadhayay,Mariella G. Filbin,Thomas P. Howard,Brenton R. Paolella,Iris Fung,Josephine S. Lee,Phil Montgomery,John M. Krill-Burger,Brian J. Abraham,Jennifer Roth,David E. Root,Richard A. Young,A. Thomas Look,Rameen Beroukhim,Jesse S. Boehm,William C. Hahn,Todd R. Golub,Aviad Tsherniak,Francisca Vazquez,Kimberly Stegmaier +28 more
TL;DR: To discover new vulnerabilities in pediatric solid tumors, genome-scale CRISPR-Cas9 loss-of-function screening and deep “omic” characterization in over 60 pediatric cancer cell lines are performed to begin defining a pediatric cancer dependency map.
Proceedings ArticleDOI
Abstract 5384: The Angiosarcoma Project: Generating the genomic landscape of an exceedingly rare cancer through a nationwide patient-driven initiative
Michael Dunphy,Esha Jain,Elana Anastasio,Mary McGillicuddy,Rachel Stoddard,Beena Thomas,Sara Balch,Kristin Anderka,Katie Larkin,Niall J. Lennon,Yen-Lin Chen,Andrew Zimmer,Esme O. Baker,Simone Maiwald,Jen Hendrey Lapan,Jason L. Hornick,Chandrajit P. Raut,George D. Demetri,Eric S. Lander,Todd R. Golub,Nikhil Wagle,Corrie A. Painter +21 more
TL;DR: This initiative demonstrates the feasibility of studying tissues from geographically dispersed patients and serves as proof of concept that patient-driven genomics efforts can democratize research for exceedingly rare cancers.