T
Todd R. Golub
Researcher at Harvard University
Publications - 454
Citations - 234100
Todd R. Golub is an academic researcher from Harvard University. The author has contributed to research in topics: Cancer & Gene expression profiling. The author has an hindex of 164, co-authored 422 publications receiving 201457 citations. Previous affiliations of Todd R. Golub include Rush University Medical Center & Boston Children's Hospital.
Papers
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Posted ContentDOI
Gene expression has more power for predicting in vitro cancer cell vulnerabilities than genomics
Joshua M. Dempster,John M. Krill-Burger,James M. McFarland,Allison Warren,Jesse S. Boehm,Francisca Vazquez,William C. Hahn,William C. Hahn,Todd R. Golub,Todd R. Golub,Aviad Tsherniak +10 more
TL;DR: It is found that expression consistently outperforms DNA for predicting vulnerabilities, including many currently stratified by canonical DNA markers, which points to the importance of exploring more comprehensive expression profiling in clinical settings.
Journal ArticleDOI
Author Correction: Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes.
Bjoern Chapuy,Chip Stewart,Andrew Dunford,Jaegil Kim,Atanas Kamburov,Robert A. Redd,Michael S. Lawrence,Michael S. Lawrence,Margaretha G.M. Roemer,Amy Li,Marita Ziepert,Annette M. Staiger,Annette M. Staiger,Jeremiah Wala,Matthew D. Ducar,Ignaty Leshchiner,Ester Rheinbay,Amaro Taylor-Weiner,Caroline A. Coughlin,Julian M. Hess,Chandra Sekhar Pedamallu,Dimitri Livitz,Daniel Rosebrock,Mara Rosenberg,Adam Tracy,Heike Horn,Paul Van Hummelen,Andrew L. Feldman,Brian K. Link,Anne J. Novak,James R. Cerhan,Thomas M. Habermann,Reiner Siebert,Andreas Rosenwald,Aaron R. Thorner,Matthew Meyerson,Matthew Meyerson,Todd R. Golub,Todd R. Golub,Rameen Beroukhim,Rameen Beroukhim,Gerald Wulf,German Ott,Scott J. Rodig,Scott J. Rodig,Stefano Monti,Donna Neuberg,Markus Loeffler,Michael Pfreundschuh,Lorenz Trümper,Gad Getz,Gad Getz,Margaret A. Shipp +52 more
TL;DR: In the version of this article originally published, an asterisk was omitted from Fig. 1a and a “NOTCH2” label was erroneously included in Fig. 4a.
Journal ArticleDOI
Corrigendum: Selective killing of cancer cells by a small molecule targeting the stress response to ROS.
Lakshmi Raj,Takao Ide,Aditi U. Gurkar,Michael Foley,Monica Schenone,Xiaoyu Li,Nicola Tolliday,Todd R. Golub,Steven A. Carr,Alykhan F. Shamji,Andrew M. Stern,Anna Mandinova,Stuart L. Schreiber,Sam W. Lee +13 more
TL;DR: This corrects the article to show that the method used to derive the H2O2 “spatially aggregating force” is a two-step process, rather than a single step, like in the previous version of this paper.
Patent
Methods and apparatus for analyzing gene expression data
TL;DR: In this paper, a self-organizing map is used to cluster gene expression patterns into groups that exhibit similar patterns, which enables one to easily analyze gene expression data from potentially thousands of genes.
Journal ArticleDOI
A phase II study of the EGFR inhibitor gefitinib in patients with acute myeloid leukemia.
Daniel J. DeAngelo,Donna Neuberg,Philip C. Amrein,Jacob E. Berchuck,Martha Wadleigh,L. Andres Sirulnik,Ilene Galinsky,Todd R. Golub,Todd R. Golub,Kimberly Stegmaier,Kimberly Stegmaier,Richard Stone +11 more
TL;DR: Routine use of the EGFR inhibitor gefitinib as a single agent for advanced AML is not appropriate because of pre-clinical activity and anecdotal cases of response to EGFR inhibitors.