S
S. J. Bielinski
Researcher at Mayo Clinic
Publications - 5
Citations - 1220
S. J. Bielinski is an academic researcher from Mayo Clinic. The author has contributed to research in topics: Genome-wide association study & SNP array. The author has an hindex of 5, co-authored 5 publications receiving 1048 citations.
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Journal ArticleDOI
The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis.
Daniel I. Swerdlow,Michael V. Holmes,Karoline Kuchenbaecker,Engmann Jel.,Tina Shah,Reecha Sofat,Yiran Guo,C Chung,Anne Peasey,Roman Pfister,Simon P. Mooijaart,Helen Ireland,Maarten Leusink,Claudia Langenberg,KaWah Li,Jutta Palmen,Phil Howard,Jackie A. Cooper,Fotios Drenos,John Hardy,Mike A. Nalls,Yun Li,Gordon D.O. Lowe,Marlene C. W. Stewart,S. J. Bielinski,Julian Peto,Nicholas J. Timpson,John Gallacher,Malcolm G. Dunlop,Richard S. Houlston,Ian Tomlinson,Ioanna Tzoulaki,Jian'an Luan,Boer Jma.,Nita G. Forouhi,N. C. Onland-Moret,Y. T. van der Schouw,Renate B. Schnabel,Jaroslav A. Hubacek,Růžena Kubínová,Migle Baceviciene,Abdonas Tamosiunas,Andrzej Pajak,Roman Topor-Madry,Sofia Malyutina,Damiano Baldassarre,Bengt Sennblad,Elena Tremoli,U de Faire,Luigi Ferrucci,S Bandenelli,Tetsu Tanaka,James F. Meschia,AB Singleton,Gerjan Navis,I. Mateo Leach,Bakker Sjl.,Ron T. Gansevoort,Ian Ford,Stephen E. Epstein,Mary-Susan Burnett,Joe Devaney,Johan Wouter Jukema,Westendorp Rgj.,G Jan de Borst,Y. van der Graaf,P A de Jong,Mailand-van der Zee A-H.,Olaf H. Klungel,A. de Boer,P. A. Doevendans,Jeffrey W. Stephens,Charles B. Eaton,Jennifer G. Robinson,JoAnn E. Manson,F G Fowkes,Timothy M. Frayling,Jenna Price,Peter H. Whincup,Richard W Morris,Debbie A Lawlor,George Davey Smith,Yoav Ben-Shlomo,Susan Redline,Leslie A. Lange,Meena Kumari,Nicholas J. Wareham,Verschuren Wmm.,Emelia J. Benjamin,John C. Whittaker,Anders Hamsten,Frank Dudbridge,Delaney Jac.,Andrew Wong,Diana Kuh,Rebecca Hardy,Berta Almoguera Castillo,John Connolly,P. van der Harst,Eric J. Brunner,Michael Marmot,Christina L. Wassel,Steve E. Humphries,P.J. Talmud,Mika Kivimäki,Folkert W. Asselbergs,Mikhail I. Voevoda,Martin Bobak,Hynek Pikhart,James G. Wilson,Hakon Hakonarson,Alexander P. Reiner,Brendan J. Keating,Naveed Sattar,Aroon D. Hingorani,Juan P. Casas +115 more
TL;DR: IL6R blockade could provide a novel therapeutic approach to prevention of coronary heart disease that warrants testing in suitably powered randomised trials and could help to validate and prioritise novel drug targets or to repurpose existing agents and targets for new therapeutic uses.
Journal ArticleDOI
Large-Scale Gene-Centric Meta-Analysis across 39 Studies Identifies Type 2 Diabetes Loci
Richa Saxena,Richa Saxena,Clara C. Elbers,Clara C. Elbers,Yiran Guo,Inga Peter,Tom R. Gaunt,Jessica L. Mega,Matthew B. Lanktree,Archana Tare,Archana Tare,Berta Almoguera Castillo,Berta Almoguera Castillo,Yun Li,Toby Johnson,Marcel Bruinenberg,Diane Gilbert-Diamond,Ramakrishnan Rajagopalan,Benjamin F. Voight,Benjamin F. Voight,Ashok Balasubramanyam,John Barnard,Florianne Bauer,Jens Baumert,Tushar Bhangale,Bernhard O. Böhm,Peter S. Braund,Paul Burton,Hareesh R. Chandrupatla,Robert Clarke,Rhonda M. Cooper-DeHoff,Errol D. Crook,George Davey-Smith,Ian N. M. Day,Anthonius de Boer,Mark C.H. De Groot,Fotios Drenos,Jane F. Ferguson,Caroline S. Fox,Clement E. Furlong,Quince Gibson,Christian Gieger,Lisa A. Gilhuijs-Pederson,Joseph T. Glessner,Anuj Goel,Yan Gong,Struan F.A. Grant,Diederick E. Grobbee,Claire E. Hastie,Steve E. Humphries,Cecilia E. Kim,Mika Kivimäki,Marcus E. Kleber,Christa Meisinger,Meena Kumari,Taimour Y. Langaee,Debbie A Lawlor,Mingyao Li,Maximilian T. Lobmeyer,Anke-Hilse Maitland-van der Zee,Matthijs F.L. Meijs,Cliona Molony,David A. Morrow,Gurunathan Murugesan,Solomon K. Musani,Christopher P. Nelson,Stephen Newhouse,Jeffery R. O'Connell,Sandosh Padmanabhan,Jutta Palmen,Sanjey R. Patel,Carl J. Pepine,Mary Pettinger,Thomas S. Price,Suzanne Rafelt,Jane E. Ranchalis,Asif Rasheed,Elisabeth A. Rosenthal,Ingo Ruczinski,Sonia Shah,Haiqing Shen,Günther Silbernagel,Erin N. Smith,Annemieke W M Spijkerman,Alice Stanton,Michael W. Steffes,Barbara Thorand,Mieke D. Trip,Pim van der Harst,Daphne L. van der A,Erik P A Van Iperen,Jessica van Setten,Jana V. van Vliet-Ostaptchouk,Niek Verweij,Bruce H. R. Wolffenbuttel,Taylor Young,M. Hadi Zafarmand,Joseph M. Zmuda,Michael Boehnke,David Altshuler,David Altshuler,Mark I. McCarthy,W. H. Linda Kao,James S. Pankow,Thomas P. Cappola,Peter S. Sever,Neil R Poulter,Mark J. Caulfield,Anna F. Dominiczak,Denis C. Shields,Deepak L. Bhatt,Li Zhang,Sean P. Curtis,John Danesh,Juan P. Casas,Juan P. Casas,Yvonne T. van der Schouw,N. Charlotte Onland-Moret,Pieter A. Doevendans,Gerald W. Dorn,Martin Farrall,Garret A. FitzGerald,Anders Hamsten,Robert A. Hegele,Aroon D. Hingorani,Marten H. Hofker,Gordon S. Huggins,Thomas Illig,Gail P. Jarvik,Julie A. Johnson,Olaf H. Klungel,William C. Knowler,Wolfgang Koenig,Winfried März,James B. Meigs,Olle Melander,Patricia B. Munroe,Braxton D. Mitchell,S. J. Bielinski,Daniel J. Rader,Muredach P. Reilly,Stephen S. Rich,Jerome I. Rotter,Danish Saleheen,Nilesh J. Samani,Eric E. Schadt,Alan R. Shuldiner,Roy L. Silverstein,Kandice Kottke-Marchant,Philippa J. Talmud,Hugh Watkins,Folkert W. Asselbergs,Paul I.W. de Bakker,Paul I.W. de Bakker,Paul I.W. de Bakker,Jeanne M. McCaffery,Cisca Wijmenga,Marc S. Sabatine,James G. Wilson,Alexander P. Reiner,Donald W. Bowden,Hakon Hakonarson,David S. Siscovick,Brendan J. Keating +163 more
TL;DR: Large-scale meta-analysis involving a dense gene-centric approach has uncovered additional loci and variants that contribute to type 2 diabetes risk and suggests substantial overlap of T2D association signals across multiple ethnic groups.
Journal ArticleDOI
Transferability and fine-mapping of glucose and insulin quantitative trait loci across populations: CARe, the Candidate Gene Association Resource.
Ching-Ti Liu,Maggie C.Y. Ng,D Rybin,Adebowale Adeyemo,S. J. Bielinski,Eric Boerwinkle,Ingrid B. Borecki,Brian E. Cade,Y. D.I. Chen,Luc Djoussé,Luc Djoussé,Myriam Fornage,Mark O. Goodarzi,Struan F.A. Grant,Xiuqing Guo,T.B. Harris,Edmond K. Kabagambe,Jorge R. Kizer,Yongmei Liu,Kathryn L. Lunetta,Kathryn L. Lunetta,Kenneth J. Mukamal,Jennifer A. Nettleton,James S. Pankow,Sanjay R. Patel,Erin M. Ramos,Laura J. Rasmussen-Torvik,Stephen S. Rich,Charles N. Rotimi,Daniel F. Sarpong,Daniel Shriner,Mario Sims,J. M. Zmuda,Susan Redline,Wen Hong L. Kao,David S. Siscovick,Jose C. Florez,Jose C. Florez,Jerome I. Rotter,Josée Dupuis,Josée Dupuis,James G. Wilson,Donald W. Bowden,James B. Meigs +43 more
TL;DR: Few glycaemic SNPs showed strict evidence of transferability from EuA to AfAs, with new signals emerging to aid fine-mapping.
Journal ArticleDOI
Circulating cellular adhesion molecules and risk of diabetes: the Multi-Ethnic Study of Atherosclerosis (MESA).
James S. Pankow,Paul A. Decker,C. Berardi,Naomi Q. Hanson,Michèle M. Sale,Weihong Tang,Alka M. Kanaya,Nicholas B. Larson,Michael Y. Tsai,Christina L. Wassel,S. J. Bielinski +10 more
TL;DR: To test the hypothesis that soluble cellular adhesion molecules would be positively and independently associated with risk of diabetes, a large number of studies have found that these molecules are positively associated with diabetes.
Journal ArticleDOI
Erratum: Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci (American Journal of Human Genetics (2012) 90 (410-425))
Richa Saxena,Clara C. Elbers,Yiran Guo,Inga Peter,Tom R. Gaunt,Jessica L. Mega,Matthew B. Lanktree,Archana Tare,Berta Almoguera Castillo,Yun Li,Toby Johnson,Marcel Bruinenberg,Diane Gilbert-Diamond,Ramakrishnan Rajagopalan,Benjamin F. Voight,Ashok Balasubramanyam,John Barnard,Florianne Bauer,Jens Baumert,Tushar Bhangale,Bernhard O. Böhm,Peter S. Braund,Paul Burton,Hareesh R. Chandrupatla,Robert Clarke,Rhonda M. Cooper-DeHoff,Errol D. Crook,George Davey-Smith,Ian N. M. Day,Anthonius de Boer,Mark C.H. De Groot,Fotios Drenos,Jane F. Ferguson,Caroline S. Fox,Clement E. Furlong,Quince Gibson,Christian Gieger,Lisa A. Gilhuijs-Pederson,Joseph T. Glessner,Anuj Goel,Yan Gong,Struan F.A. Grant,Diederick E. Grobbee,Claire E. Hastie,Steve E. Humphries,Cecilia E. Kim,Mika Kivimäki,Marcus E. Kleber,Christa Meisinger,Meena Kumari,Taimour Y. Langaee,Debbie A Lawlor,Mingyao Li,Maximilian T. Lobmeyer,Anke-Hilse Maitland-van der Zee,Matthijs F.L. Meijs,Cliona Molony,David A. Morrow,Gurunathan Murugesan,Solomon K. Musani,Christopher P. Nelson,Stephen Newhouse,Jeffery R. O'Connell,Sandosh Padmanabhan,Jutta Palmen,Sanjey R. Patel,Carl J. Pepine,Mary Pettinger,Thomas S. Price,Suzanne Rafelt,Jane E. Ranchalis,Asif Rasheed,Elisabeth A. Rosenthal,Ingo Ruczinski,Sonia Shah,Haiqing Shen,Günther Silbernagel,Erin N. Smith,Annemieke W M Spijkerman,Alice Stanton,Michael W. Steffes,Barbara Thorand,Mieke D. Trip,Pim van der Harst,Daphne L. van der A,Erik P A Van Iperen,Jessica van Setten,Jana V. van Vliet-Ostaptchouk,Niek Verweij,Bruce H. R. Wolffenbuttel,Taylor Young,M. Hadi Zafarmand,Joseph M. Zmuda,Michael Boehnke,David Altshuler,Mark I. McCarthy,W. H. Linda Kao,James S. Pankow,Thomas P. Cappola,Peter S. Sever,Neil R Poulter,Mark J. Caulfield,Anna F. Dominiczak,Denis C. Shields,Deepak L. Bhatt,Li Zhang,Sean P. Curtis,John Danesh,Juan P. Casas,Yvonne T. van der Schouw,N. Charlotte Onland-Moret,Pieter A. Doevendans,Gerald W. Dorn,Martin Farrall,Garret A. FitzGerald,Anders Hamsten Robert Hegele,Aroon D. Hingorani,Marten H. Hofker,Gordon S. Huggins,Thomas Illig,Gail P. Jarvik,Julie A. Johnson,Olaf H. Klungel,William C. Knowler,Wolfgang Koenig,Winfried März,James B. Meigs,Olle Melander,Patricia B. Munroe,Braxton D. Mitchell,S. J. Bielinski,Daniel J. Rader,Muredach P. Reilly,Stephen S. Rich,Jerome I. Rotter,Danish Saleheen,Nilesh J. Samani,Eric E. Schadt,Alan R. Shuldiner,Roy L. Silverstein,Kandice Kottke-Marchant,Philippa J. Talmud,Hugh Watkins,Folkert W. Asselbergs,Paul I.W. de Bakker,Jeanne M. McCaffery,Cisca Wijmenga,Marc S. Sabatine,James G. Wilson,Alexander P. Reiner,Donald W. Bowden,Hakon Hakonarson,David S. Siscovick,Brendan J. Keating +153 more