P
P. A. Doevendans
Researcher at Utrecht University
Publications - 21
Citations - 1114
P. A. Doevendans is an academic researcher from Utrecht University. The author has contributed to research in topics: Restenosis & Percutaneous coronary intervention. The author has an hindex of 8, co-authored 21 publications receiving 948 citations.
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Journal ArticleDOI
The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis.
Daniel I. Swerdlow,Michael V. Holmes,Karoline Kuchenbaecker,Engmann Jel.,Tina Shah,Reecha Sofat,Yiran Guo,C Chung,Anne Peasey,Roman Pfister,Simon P. Mooijaart,Helen Ireland,Maarten Leusink,Claudia Langenberg,KaWah Li,Jutta Palmen,Phil Howard,Jackie A. Cooper,Fotios Drenos,John Hardy,Mike A. Nalls,Yun Li,Gordon D.O. Lowe,Marlene C. W. Stewart,S. J. Bielinski,Julian Peto,Nicholas J. Timpson,John Gallacher,Malcolm G. Dunlop,Richard S. Houlston,Ian Tomlinson,Ioanna Tzoulaki,Jian'an Luan,Boer Jma.,Nita G. Forouhi,N. C. Onland-Moret,Y. T. van der Schouw,Renate B. Schnabel,Jaroslav A. Hubacek,Růžena Kubínová,Migle Baceviciene,Abdonas Tamosiunas,Andrzej Pajak,Roman Topor-Madry,Sofia Malyutina,Damiano Baldassarre,Bengt Sennblad,Elena Tremoli,U de Faire,Luigi Ferrucci,S Bandenelli,Tetsu Tanaka,James F. Meschia,AB Singleton,Gerjan Navis,I. Mateo Leach,Bakker Sjl.,Ron T. Gansevoort,Ian Ford,Stephen E. Epstein,Mary-Susan Burnett,Joe Devaney,Johan Wouter Jukema,Westendorp Rgj.,G Jan de Borst,Y. van der Graaf,P A de Jong,Mailand-van der Zee A-H.,Olaf H. Klungel,A. de Boer,P. A. Doevendans,Jeffrey W. Stephens,Charles B. Eaton,Jennifer G. Robinson,JoAnn E. Manson,F G Fowkes,Timothy M. Frayling,Jenna Price,Peter H. Whincup,Richard W Morris,Debbie A Lawlor,George Davey Smith,Yoav Ben-Shlomo,Susan Redline,Leslie A. Lange,Meena Kumari,Nicholas J. Wareham,Verschuren Wmm.,Emelia J. Benjamin,John C. Whittaker,Anders Hamsten,Frank Dudbridge,Delaney Jac.,Andrew Wong,Diana Kuh,Rebecca Hardy,Berta Almoguera Castillo,John Connolly,P. van der Harst,Eric J. Brunner,Michael Marmot,Christina L. Wassel,Steve E. Humphries,P.J. Talmud,Mika Kivimäki,Folkert W. Asselbergs,Mikhail I. Voevoda,Martin Bobak,Hynek Pikhart,James G. Wilson,Hakon Hakonarson,Alexander P. Reiner,Brendan J. Keating,Naveed Sattar,Aroon D. Hingorani,Juan P. Casas +115 more
TL;DR: IL6R blockade could provide a novel therapeutic approach to prevention of coronary heart disease that warrants testing in suitably powered randomised trials and could help to validate and prioritise novel drug targets or to repurpose existing agents and targets for new therapeutic uses.
Journal ArticleDOI
Bone marrow cell therapy after acute myocardial infarction: the HEBE trial in perspective, first results
A. M. Van der Laan,Alexander Hirsch,Robin Nijveldt,P. A. van der Vleuten,W.J. van der Giessen,P. A. Doevendans,Johannes Waltenberger,J. M. ten Berg,Wim R.M. Aengevaeren,Jaap Jan Zwaginga,Bart J. Biemond,A.C. van Rossum,J. G. P. Tijssen,Freek J. Zijlstra,Jan J. Piek +14 more
TL;DR: The results from the HEBE trial will provide detailed information about the effects of intracoronary BMMC therapy on post-infarct left ventricular recovery and significantly contribute to the development of improved cell-based therapies, aiming at optimising post- infarct recovery and preventing heart failure.
Journal ArticleDOI
Common variants of multiple genes that control reverse cholesterol transport together explain only a minor part of the variation of HDL cholesterol levels
S.M. Boekholdt,Olga W. Souverein,Michael W.T. Tanck,G.K. Hovingh,Jan Albert Kuivenhoven,R I G Peters,Hans Jansen,P M H Schiffers,E. E. van der Wall,P. A. Doevendans,Pieter H. Reitsma,A. H. Zwinderman,J.J.P. Kastelein,Johan Wouter Jukema +13 more
TL;DR: The hypothesis that multiple, mildly penetrant, but highly prevalent genetic variants explain part of the variation of high‐density lipoprotein cholesterol (HDL‐C) plasma levels is supported, albeit to a very modest extent.
Journal ArticleDOI
Interleukin 10: a new risk marker for the development of restenosis after percutaneous coronary intervention
PS Monraats,Fina A S Kurreeman,Douwe Pons,V. D. K. D. Sewgobind,FR de Vries,Aeilko H. Zwinderman,M. P. M. de Maat,P. A. Doevendans,R. J. de Winter,René A. Tio,Johannes Waltenberger,Twj Huizinga,Daniel Eefting,Paul H.A. Quax,Rune R. Frants,A. van der Laarse,E. E. van der Wall,Johan Wouter Jukema +17 more
TL;DR: The findings demonstrate that IL-10 is associated with restenosis and therefore support the hypothesis that anti-inflammatory genes also may be involved in developing restenotic, and may provide a new targeting gene for drug-eluting stents.
Journal ArticleDOI
Rationale and design of the Measuring Athlete’s Risk of Cardiovascular events (MARC) study
Thijs L Braber,A. Mosterd,Niek H J Prakken,P. A. Doevendans,W.P.Th.M. Mali,Frank J G Backx,D. E. Grobbee,Rienk Rienks,Hendrik M. Nathoe,M. L. Bots,Birgitta K. Velthuis +10 more
TL;DR: The study protocol of the Measuring Athlete’s Risk of Cardiovascular events (MARC) study is presented, which aims to assess the additional value of CCT to a routine SME in asymptomatic middle-aged sportsmen ≥45 years without known CAD.