Jeffrey W. Stephens

TL;DR: IL6R blockade could provide a novel therapeutic approach to prevention of coronary heart disease that warrants testing in suitably powered randomised trials and could help to validate and prioritise novel drug targets or to repurpose existing agents and targets for new therapeutic uses.

TL;DR: The present data suggest that shorter LTL is associated with the presence of T2D and this could be partially attributed to the high oxidative stress in these patients.

TL;DR: Findings suggest a role for reactive oxygen species in inflammation-induced endothelial dysfunction, which reduces vascular NO bioavailability and increases oxidative stress and are partially reversible with local anti-oxidants.

TL;DR: The role that oxidative stress may play in diabetes and related cardiovascular disease (CVD) and how oxidative damage may be measured in the plasma are looked at and the discovery of an 'easy to measure marker' of oxidative stress might be incorporated into risk prediction in Diabetes and cardiovascular disease.

TL;DR: A common CRP gene polymorphism is associated with important differences in CRP concentrations, free from confounding, and the null association of this variant with coronary events suggests possible residual confounding in the CRP-coronary event association in observational studies, though the confidence limits are still compatible with a modest causal effect.