Yon-Dschun Ko

TL;DR: To investigate the role of genetically determined individual predispositions in enzymes of xenobiotic metabolism and in repair enzymes under the exogenous risk factor tobacco smoke in the carcinogenesis of HNSCC, a case-control study on 312 cases and 300 noncancer controls is conducted.

TL;DR: It is suggested that an increased catabolism of estrogens by CYP2C19 may lead to decreased estrogen levels and therefore reduces breast cancer risk and seems to be stronger in combination with long-term intake of supplemental estrogens during hormone therapy.

TL;DR: In this paper, the authors evaluated pharmacokinetically (PK)-guided paclitaxel dosing in patients with advanced non-small-cell lung cancer (NSCLC) to avoid supra- or subtherapeutic exposure.

TL;DR: A novel susceptibility locus at 3p21 is identified, and previous suggestive evidence that rs6964587 at 7q21 is associated with risk is confirmed, and further fine-mapping and functional studies are required to identify the underlying risk-modifying variants and the genes through which they act.

TL;DR: In this paper, the impact of AKAP variants on breast cancer risk was evaluated by genotyping six nonsynonymous single nucleotide polymorphisms that were predicted to be deleterious and found two (M463I, 1389G>T and N2792S, 8375A>G) to be associated with an allele dose-dependent increase in risk of familial breast cancer in a German population.