Papers published on a yearly basis
Papers
More filters
TL;DR: In this protocol, nuclease digestion of an oligonucleotide is followed by dephosphorylation and HPLC analysis of the monomers on a reversed‐phase C18 column to detect and quantitate a wide variety of nucleobase modifications in oligon nucleotides.
Abstract: In this protocol, nuclease digestion of an oligonucleotide is followed by dephosphorylation and HPLC analysis of the monomers on a reversed-phase C18 column. This method can be used to detect and quantitate a wide variety of nucleobase modifications in oligonucleotides. Integrated areas of the nucleoside chromatogram give precise quantitation of nucleoside composition when the relative extinction coefficient cofactors are applied to the sum of the areas of the four bases. The protocol is also useful for analysis of oligonucleotides containing conjugated moieties and carbohydrate modifications.
17 citations
TL;DR: It is suggested that restoring Bax expression may provide a clinical approach for restoring the normal numbers of epithelial cells and reduced mucous hypersecretion in asthma.
Abstract: The present studies were designed to determine whether our findings in mice showing that the Bcl-2-associated protein X (Bax), which plays a role in the resolution of allergen-induced mucous cell m...
17 citations
TL;DR: A novel method is established for the quantification of lipid alkyl radicals via nitroxyl radical spin-trapping via soybean lipoxygenase-1 or the radical initiator 2,2′-azobis(2,4-dimethyl-valeronitrile).
17 citations
TL;DR: By using microbore HPLC methodology, a 14 kDa protein extremely homologous to Cystatin S, but amino-terminally extended by eight amino acids is discovered, becoming the first such protein to be discovered by this route.
17 citations
TL;DR: A useful method for preparing a synthetic peptide-carrying protein for specific antibody production was established and antiserum against the conjugate from a rabbit effectively abolished the stimulatory activity of the monitor peptide in the rat small intestine.
17 citations
Authors
Showing all 1521 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Richard A. Gibbs | 172 | 889 | 249708 |
| Friedrich C. Luft | 113 | 1095 | 47619 |
| Alexander N. Glazer | 71 | 208 | 21068 |
| Vineet Bafna | 68 | 236 | 42574 |
| Kevin R. Coombes | 63 | 308 | 23592 |
| Darryl J. Pappin | 61 | 170 | 29409 |
| Mark D. Johnson | 60 | 289 | 16103 |
| György Marko-Varga | 56 | 409 | 12600 |
| Paul Thomas | 56 | 128 | 44810 |
| Gerald Zon | 55 | 256 | 11126 |
| Michael W. Hunkapiller | 51 | 130 | 29756 |
| Bjarni V. Halldorsson | 51 | 145 | 13180 |
| David H. Hawke | 50 | 157 | 9824 |
| Ellson Y. Chen | 50 | 71 | 28836 |
| Sridhar Hannenhalli | 49 | 162 | 21959 |