Chinese Center for Disease Control and Prevention

About: Chinese Center for Disease Control and Prevention is a government organization based out in Beijing, China. It is known for research contribution in the topics: Population & Acquired immunodeficiency syndrome (AIDS). The organization has 16037 authors who have published 15098 publications receiving 423452 citations. The organization is also known as: China CDC & CCDC.

Schistosome feeding and regurgitation.

Abstract: Schistosomes are parasitic flatworms that infect >200 million people worldwide, causing the chronic, debilitating disease schistosomiasis. Unusual among parasitic helminths, the long-lived adult worms, continuously bathed in blood, take up nutrients directly across the body surface and also by ingestion of blood into the gut. Recent proteomic analyses of the body surface revealed the presence of hydrolytic enzymes, solute, and ion transporters, thus emphasising its metabolic credentials. Furthermore, definition of the molecular mechanisms for the uptake of selected metabolites (glucose, certain amino acids, and water) establishes it as a vital site of nutrient acquisition. Nevertheless, the amount of blood ingested into the gut per day is considerable: for males ∼100 nl; for the more actively feeding females ∼900 nl, >4 times body volume. Ingested erythrocytes are lysed as they pass through the specialized esophagus, while leucocytes become tethered and disabled there. Proteomics and transcriptomics have revealed, in addition to gut proteases, an amino acid transporter in gut tissue and other hydrolases, ion, and lipid transporters in the lumen, implicating the gut as the site for acquisition of essential lipids and inorganic ions. The surface is the principal entry route for glucose, whereas the gut dominates amino acid acquisition, especially in females. Heme, a potentially toxic hemoglobin degradation product, accumulates in the gut and, since schistosomes lack an anus, must be expelled by the poorly understood process of regurgitation. Here we place the new observations on the proteome of body surface and gut, and the entry of different nutrient classes into schistosomes, into the context of older studies on worm composition and metabolism. We suggest that the balance between surface and gut in nutrition is determined by the constraints of solute diffusion imposed by differences in male and female worm morphology. Our conclusions have major implications for worm survival under immunological or pharmacological pressure.

The prevalence of body overweight and obesity and its changes among Chinese people during 1992 to 2002

Abstract: Objective To describe the prevalence of body overweight and obesity and its changes among Chinese people during 1992-2002, and to provide scientific basis for developing intervention strategies for obesity in China. Methods The data from "1992 China third National Nutrition Survey" (78,704 subjects, 38,323 male and 40,381 female) and from "2002 China National Nutrition and Health Survey" (209,849 subjects, 101,377 male and 108,472 female) were used in this study. The overweight and obesity were defined by using WHO Z-score criteria for children younger than 7 years old, Chinese age-, sex-specific BMI criteria for children aged 7-17 years, and Chinese BMI criteria for adults. Results The overall prevalence of overweight and obesity of Chinese people was increased by 38.6% and 80.6%, respectively during the period of 1992-2002. The prevalence of overweight and obesity of Chinese people aged 0-6 years, 7-17 years, 18-44 years, 45-59 years and above 60 years was increased 31.7%, 17.9%, 66.7%, 45.2% and 43.7%, respectively. The increase of the prevalence of overweight and obesity was higher in girls younger than 6 years than their male counterparts, while among other age groups, that were higher in boys than girls. The prevalence of overweight and obesity among people living in rural areas was lower than that of their urban counterparts, while the increment of overweight and obesity prevalence among rural people was greater than that of their urban counterparts. It was estimated that another 70 million overweight and 30 million obese Chinese people emerged in China from 1992 to 2002. Conclusion The prevalence of overweight and obesity of Chinese people was increased rapidly in the past decade, which had affected 260 million Chinese people. It would continue to increase in the near future if effective intervention measures have not been taken.

Comparison of assessment of food intakes by using 3 dietary survey methods

Abstract: Objective To analyze the difference and correlation of food intakes assessed by Food Weighted Record, 24 Hours Recall and Food Frequency Questionnaire (FFQ) methods. Subjects The data of 2002 China National Nutrition and Health Survey were used. All 23,198 subjects (male 11,107, female 12,091) finished all three dietary survey methods. Food Weighted Record method weighted all food items consumed at home by all family members in last 3 days; 24 Hours Recall recorded all food items the subjects consumed at and out home in last 3 days; FFQ recorded the main 33 categories food items that the subjects consumed at and out home in last year. Results Compared to Food Weighted Record method, food intakes assessed by 24 hours recall were similar, and the relative differences were less than 10% of most food items. The proportion of over-report and under-report (+/- 25%) by 24 Hours Recall were less than 40%. The correlation coefficients of food intakes between Food Weighted Record and 24 Hours Recall methods ranged from 0.58 to 0.88. The results from Food Weighted Record and FFQ were similar among the high frequently consumed food items. The relative differences of the food intakes investigated between Food Weighted Record and FFQ were less than 15% and the proportion of over-report and under-report (+/- 25%) by FFQ were more than 50%. The correlation coefficients of food intakes between Food Weighted Record and FFQ ranged from 0.08 to 0.76. Conclusion Food intakes might be assessed accurately by the Food Weighted Record revised 24 Hours Recall method, and FFQ method be also used to assess the food intakes, especially for the frequently consumed food items, as to studying the relationship between food consumption and health.