Hai phong University Of Medicine and Pharmacy

About: Hai phong University Of Medicine and Pharmacy is a education organization based out in Haiphong, Vietnam. It is known for research contribution in the topics: Population & Health care. The organization has 620 authors who have published 403 publications receiving 8425 citations. The organization is also known as: Hai Phong Medical University.

Biomechanics of Noncarious Cervical Lesions

Abstract: Noncarious cervical lesions (NCCLs) restoration represents a unique clinical situation due to their multifactorial etiology. Though the mechanical theory of cervical lesions formation is widely accepted, its mechanism is not fully understood. The incidence of NCCL refers to the facial and oral aspects of the teeth. Finite Elements Method (FEM) were drawn up, applied with various occlusal forces and analyzed in order to observe the stress distribution. The standard biomechanical unit involves restorative material, tooth structure and interface between the restoration and tooth. The purpose of this study was to examine the NCCL formation caused by occlusal forces and the behavior of restored and unrestored lesions.

Efficacy and safety of nanoparticle albumin-bound paclitaxel versus paclitaxel in metastatic breast cancer

Abstract: Purpose: To compare the efficacy and safety of nab-pacitaxel versus paclitaxel in patients with metastatic breast cancer. Patients and Methods: A total of 92 patients with metastatic breast cancer received chemotherapy for nab-palitaxel versus paclitaxel at the dose of 260mg/m2 and 175mg/m2 respectively for total 8 cycles at the Hospital of Hue University of Medicine and Pharmacy and of Hue Central Hospital from February 2013 to October 2015. Results: The mean age in two groups of patients is 54 and 53 years old. The ECOG index was 0-1 in both groups. Menopausal status accounted for 73% in 2 groups. Dominant metastatic organ sites of two groups are bone, lung, liver. Multiple sites of metastasis in nab-paclitaxel and paclitaxel groups were 18% and 20%, respectively. The response rate of patients with nab-paclitaxel was 54.5% versus 31.2% in the paclitaxel group, p = 0.024. The time to progression was 8.46 months in the nab-paclitaxel group and 7.38 months in the paclitaxel group, p = 0.019. The median survival time of the nab-paclitaxel and paclitaxel groups was 28.89 and 27.79 months, respectively, p = 0.554. Neutropenia rates in the nab-pacitaxel and paclitaxel groups were 27.3% and 39.6% respectively, p = 0.033. Other toxicities were similar in both groups. Conclusion: Nab-Paclitaxel has clinical benefits over paclitaxel in metastatic breast cancer because of higher response rate, prolonged time to progression and less neutropenia. Key words: metastatic breast cancer, nab-paclitaxel, paclitaxel

Approaches on H5N1 Avian Influenza Spreading in Relation with Human Health Risk

Abstract: Recent experiences with highly pathogenic H5N1 avian influenza have given the world its first advance warning that another influenza pandemic may be imminent. Given the serious consequences of past pandemics, this advance warning has stimulated a search for ways to prevent such an event from occurring through preparedness, rapid response and containment. The rapid response and containment strategy aims to stop, or at least slow the spread of pandemic influenza at the source of its emergence in order to minimize global morbidity and mortality.

Cephalometric measurements and their correlation to the diurnal sleepiness grade in patients with obstructive sleep apnea syndrome

Abstract: AIM: The evaluation of the oropharyngeal and facial modifications made by cephalometry represents a complementary method of analysis of patients with obstructive sleep apnea syndrome. MATERIAL AND METHOD: The anatomical modifications frequently associated with the sleeping respiratory pathology can be evaluated with satisfactory results through the correlation of the clinical data made by flexible pharyngoscopy with the results of the cephalometric examinations. During the cephalometric examinations the screening of the following parameters is being made: the posterior airways space (PAS), uvula size PM-PU, distance between the inferior border of the mandibula and hyoid (MPH = maximum palate height). The literature demonstrates in the case of the obstructive sleep apnea syndrome at least two of these parameters must be modified. RESULTS: Thirty (30) patients with sleep respiratory disfunctions like snoring and obstructive sleep apnea have been included in this prospective study, following the cephalometric investigations with all its parameters mentioned earlier. The obtained data were correlated to the diurnal sleepiness/daytime somnolence grade ESS and the value of the apnea-hypopnea index (AHI). It can be claimed as a fact, the anatomical modifications frequently associated with the obstructive sleep apnea syndrome evidenced on cephalometry, these are in relationship with the AHI value and can be correlated to the diurnal sleepiness/daytime somnolence grade measured on the Epworth scale – ESS.

Micellar Electrokinetic Capillary Chromatography of 1,4-Benzodiazepine Derivates and their Degradation Products

Abstract: The aim of this work is to elaborate a fast and reliable capillary electrophoresis method, for the separation of 1,4-benzodiazepine (BZD) derivates and their degradation products in acidic medium and in UV light. Because BZDs are neutral, hydrophobic compounds, the most efficient method proved to be micellar elektrokinetic capillary chromatography (MECC). For the separation we used a sodium tetraborate buffer with tensioactive agent (sodium dodecyl sulphate SDS) and an organic modifier (methanol). We also optimized the analytical conditions, and studied the effects of the SDS and methanol concentrations and buffer pH on the determination efficiency.