Hai phong University Of Medicine and Pharmacy

About: Hai phong University Of Medicine and Pharmacy is a education organization based out in Haiphong, Vietnam. It is known for research contribution in the topics: Population & Health care. The organization has 620 authors who have published 403 publications receiving 8425 citations. The organization is also known as: Hai Phong Medical University.

Recouvrement des pertes de substance de la pulpe des doigts par des lambeaux locaux à Hanoï, Vietnam

Abstract: The accidental loss of fingertip soft tissues, which may expose tendons and bones, is a common injury in emergency departments. If these lesions are poorly treated, they can impair fine motor skills and tactile sensitivity of the fingertips. The study was conducted on 30 patients (24 males and 6 females) with 32 soft tissue defects of the fingertip treated in emergency plastic surgery with local pedicled flap at the Plastic Surgery Department of Saint Paul Hospital Hanoi from 01/2016 to 06/2017. The most common cause of injury (21/30) was occupational accidents. At the time of the accident, 12 patients did not have personal protective equipment (PPE). Among 18 patients who had one, eight had incomplete equipment. Of 32 implanted skin flaps, 31 survived completely without necrosis or infection, only one being affected by epidermolysis. Postoperative evaluation showed excellent motor skills for 31/32 fingers and a sensitivity restoration at S4 level for 27/32. Workplace accident is the main cause of fingers soft tissue defects. Covering the fingers soft tissue defects with local pedicled flap in emergency preserves the fine motor function and the delicated tactile sensation of the fingers.

Reply to “Questions about and speculations on the incidence of idiopathic polyhydramnios by fetal gender”

Abstract: I would like to thank Kim et al. [1] on behalf of all authors of our paper for their interest and suggestions. A multiple regression analysis has not been performed in our study, since our singe parameter was the fetal gender to compare with polyhydramnios. Therefore, we do not believe that a multiple regression analysis would be defining the relation of polyhydramnios statistically further. The measurements of the amniotic fluid index (AFI) in our database have been carried out during the daytime. We did not use any protocol to measure the AFI at night. We, therefore, do not have any collected data of AFI measurements at nighttime. Although there has been an interesting hypothesis raised, we do not believe that the differences in AFI measurements can be in any help to predict the nocturnal enuresis. There have been no documented acute or daily changes of the AFI levels in the literature. We could not find any relationship between idiopathic polyhydramnios and postnatal bladder capacity.

Premature Ejaculation and Erectile Dysfunction in Male Partners of Infertile Couples: Prevalence and Correlation

Abstract: Objectives: The frequency of, and relationship between, the various manifestations of male sexual dysfunction in infertile couples have been poorly investigated, especially in Vietnam. Our study ai...

Proinflammatory Cytokines Significantly Stimulate Extracellular Vesicle Production by Adipose-Derived and Umbilical Cord-Derived Mesenchymal Stem Cells

Abstract: Exosomes as well as other extracellular vesicles (EVs) play an important role in cell–cell communication. Recently, EVs have been used as a platform for cellular therapy for conditions such as degenerative diseases. EVs were demonstrated to stimulate angiogenesis, cell proliferation, and immune modulation. This study aims to determine the factors, particularly proinflammatory factors, can stimulate adipose-derived mesenchymal stem cells (ADSCs) and umbilical cord-derived mesenchymal stem cells (UC-MSCs) to generate exosomes and EVs. ADSCs and UC-MSCs were isolated, proliferated, and characterized from adipose tissue and umbilical cord tissue, respectively, according to previously published protocols. The isolated MSCs were treated in vitro with proinflammatory cytokines (including TNF-alpha and IFN-gamma) for 24, 48, and 96 h at three different concentrations (5, 10, and 20 ng/mL). The number count of generated EVs/exosomes was determined by flow cytometry; additionally, exosomes were assessed for amount of nucleic acids and for morphology (via transmission electron microscopy). The results showed that TNF-alpha and IFN-gamma stimulate MSCs from both umbilical cord and adipose tissue to produce a greater number of exosomes and EVs. However, longer culture with proinflammatory cytokines (>96 h) led to a reduction of EV production compared to shorter times (24 or 48 h). Our observations show that EVs are effective cargos for delivery of information in cell–cell communication and are modulated by proinflammatory cytokines in a dose-dependent manner.