Jadavpur University

About: Jadavpur University is a education organization based out in Kolkata, India. It is known for research contribution in the topics: Population & Fuzzy logic. The organization has 10856 authors who have published 27678 publications receiving 422069 citations. The organization is also known as: JU & Jadabpur University.

Enhancing bioavailability and hepatoprotective activity of andrographolide from Andrographis paniculata, a well-known medicinal food, through its herbosome.

Abstract: BACKGROUND:Andrographis paniculata is a health food used extensively in Southeast Asia, India and China and contains the pharmacologically important phytochemical andrographolide. Although andrographolide has antihepatotoxic activity, its bioavailability from A. paniculata is restricted by its rapid clearance and high plasma protein binding. The aim of this study was to formulate a herbosome of andrographolide with a naturally occurring phospholipid in order to enhance the bioavailability and hepatoprotective activity of andrographolide in rats. RESULTS: Andrographolide herbosome equivalent to 25 and 50 mg kg−1 andrographolide significantly protected the liver of rats, restoring hepatic enzyme activities with respect to carbon tetrachloride-treated animals (P < 0.05 and P < 0.01 respectively). The rat plasma concentration of andrographolide obtained from the complex equivalent to 25 mg kg−1 andrographolide (Cmax = 9.64 µg mL−1) was higher than that obtained from 25 mg kg−1 andrographolide (Cmax = 6.79 µg mL−1), and the complex maintained its effective plasma concentration for a longer period of time. CONCLUSION: The results proved that the andrographolide complex produced by this method has better bioavailability and hence improved hepatoprotective activity compared with andrographolide at the same dose. Andrographolide complexation is therefore helpful in solving the problem of rapid clearance and low elimination half-life associated with andrographolide from A. paniculata. Copyright © 2009 Society of Chemical Industry

Minimally deformed anisotropic model of class one space-time by gravitational decoupling

Abstract: In this article, we have presented a static anisotropic solution of stellar compact objects for self-gravitating system by using minimal geometric deformation techniques in the framework of embedding class one space-time. For solving of this coupling system, we deform this system into two separate system through the geometric deformation of radial components for the source function $$\lambda (r)$$ by mapping: $$e^{-\lambda (r)}\rightarrow e^{-\tilde{\lambda }(r)}+\beta \,g(r)$$, where g(r) is deformation function. The first system corresponds to Einstein’s system which is solved by taking a particular generalized form for source function $$\tilde{\lambda }(r)$$ while another system is solved by choosing well-behaved deformation function g(r). To test the physical viability of this solution, we find complete thermodynamical observable as pressure, density, velocity, and equilibrium condition via. TOV equation etc. In addition to the above, we have also obtained the moment of inertia (I), Kepler frequency (v), compression modulus ($$K_e$$) and stability for this coupling system. The M–R curve has been presented for obtaining the maximum mass and corresponding radius of the compact objects.

Tetranuclear copper(II)-Schiff-base complexes as active catalysts for oxidation of cyclohexane and toluene

Abstract: Three new Cu(II) complexes, [Cu4(O)(Ln)2(CH3COO)4] where HL1 = 4-methyl-2,6-bis(2-fluoroethyliminomethyl) phenol for complex 1, HL2 = 4-methyl-2,6-bis(2-chloroethyliminomethyl) phenol for complex 2·0.25CH3CN and HL3 = 4-methyl-2,6-bis(2-bromoethyliminomethyl) phenol for complex 3 have been synthesized and characterized by elemental analysis, FTIR, UV-vis spectroscopy, and electrospray ionization mass spectroscopy. The structure of complex 2·0.25CH3CN has also been confirmed by single crystal X-ray diffraction analysis. These complexes have been found to be active catalysts for the oxidation of cyclohexane and toluene in the presence of hydrogen peroxide as the oxidant under mild conditions. Cyclohexane is oxidized to yield cyclohexanol and cyclohexanone, whereas toluene is oxidized to benzyl alcohol and benzaldehyde.

Studies on antiinflammatory effect of Cassia tora leaf extract (Fam. leguminosae)

Abstract: The antiinflammatory effect of the methanol extract of the leaves of Cassia tora was investigated against carrageenin, histamine, serotonin and dextran-induced rat hind paw oedema. It exhibited significant antiinflammatory activity against all these agents. The extract (400 mg/kg) showed maximum inhibition of oedema of 40.33%, 31.37%, 53.57% and 29.15% at the end of 3 h with carrageenin, dextran, histamine and serotonin-induced rat paw oedema, respectively. Using a chronic test, the granuloma pouch in rats, the extract exhibited a 48.13% reduction in granuloma weight. © 1998 John Wiley & Sons, Ltd.