Institution
Laboratory of Molecular Biology
Facility•Cambridge, Cambridgeshire, United Kingdom•
About: Laboratory of Molecular Biology is a facility organization based out in Cambridge, Cambridgeshire, United Kingdom. It is known for research contribution in the topics: Gene & RNA. The organization has 19395 authors who have published 24236 publications receiving 2101480 citations.
Topics: Gene, RNA, DNA, Population, Receptor
Papers published on a yearly basis
Papers
More filters
TL;DR: It is shown that certain sequence-dependent modulations in structure appear to determine the rotational positioning of DNA about the nucleosome.
650 citations
TL;DR: Recon reconstructions of the entire brain of an adult female fly show that this freely available EM volume supports mapping of brain-spanning circuits, which will significantly accelerate Drosophila neuroscience.
650 citations
TL;DR: Current evidence suggests that protein kinases or protein phosphatases with a specificity for serine/threonine-proline residues are involved in the abnormal phosphorylation of tau.
649 citations
TL;DR: It is shown that astrocytes secrete Sonic hedgehog and that BBB ECs express Hedgehog (Hh) receptors, which together promote BBB formation and integrity during embryonic development and adulthood.
Abstract: The blood-brain barrier (BBB) is composed of tightly bound endothelial cells (ECs) and perivascular astrocytes that regulate central nervous system (CNS) homeostasis. We showed that astrocytes secrete Sonic hedgehog and that BBB ECs express Hedgehog (Hh) receptors, which together promote BBB formation and integrity during embryonic development and adulthood. Using pharmacological inhibition and genetic inactivation of the Hh signaling pathway in ECs, we also demonstrated a critical role of the Hh pathway in promoting the immune quiescence of BBB ECs by decreasing the expression of proinflammatory mediators and the adhesion and migration of leukocytes, in vivo and in vitro. Overall, the Hh pathway provides a barrier-promoting effect and an endogenous anti-inflammatory balance to CNS-directed immune attacks, as occurs in multiple sclerosis.
648 citations
TL;DR: The methods are of use both to those trying to interpret the function of newly determined sequences and to those studying the molecular mechanisms involved in the recognition of these special signal sequences.
Abstract: This paper describes computer methods for locating signals in nucleic acid sequences The signals include ribosome binding sites, promoter sequences and splice junctions The methods are of use both to those trying to interpret the function of newly determined sequences and to those studying the molecular mechanisms involved in the recognition of these special signal sequences
647 citations
Authors
Showing all 19431 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Robert J. Lefkowitz | 214 | 860 | 147995 |
| Ronald M. Evans | 199 | 708 | 166722 |
| Tony Hunter | 175 | 593 | 124726 |
| Marc G. Caron | 173 | 674 | 99802 |
| Mark Gerstein | 168 | 751 | 149578 |
| Timothy A. Springer | 167 | 669 | 122421 |
| Harvey F. Lodish | 165 | 782 | 101124 |
| Ira Pastan | 160 | 1286 | 110069 |
| Bruce N. Ames | 158 | 506 | 129010 |
| Philip Cohen | 154 | 555 | 110856 |
| Gerald M. Rubin | 152 | 382 | 115248 |
| Ashok Kumar | 151 | 5654 | 164086 |
| Kim Nasmyth | 142 | 294 | 59231 |
| Kenneth M. Yamada | 139 | 446 | 72136 |
| Harold E. Varmus | 137 | 496 | 76320 |