Marche Polytechnic University

About: Marche Polytechnic University is a education organization based out in Ancona, Italy. It is known for research contribution in the topics: Population & Cancer. The organization has 5905 authors who have published 15769 publications receiving 382286 citations. The organization is also known as: Universitá Politecnica delle Marche & Universita Politecnica delle Marche.

Mesoamerican origin of the common bean (Phaseolus vulgaris L.) is revealed by sequence data

Abstract: Knowledge about the origins and evolution of crop species represents an important prerequisite for efficient conservation and use of existing plant materials. This study was designed to solve the ongoing debate on the origins of the common bean by investigating the nucleotide diversity at five gene loci of a large sample that represents the entire geographical distribution of the wild forms of this species. Our data clearly indicate a Mesoamerican origin of the common bean. They also strongly support the occurrence of a bottleneck during the formation of the Andean gene pool that predates the domestication, which was suggested by recent studies based on multilocus molecular markers. Furthermore, a remarkable result was the genetic structure that was seen for the Mesoamerican accessions, with the identification of four different genetic groups that have different relationships with the sets of wild accessions from the Andes and northern Peru–Ecuador. This finding implies that both of the gene pools from South America originated through different migration events from the Mesoamerican populations that were characteristic of central Mexico.

Distribution of microbial communities in a forest soil profile investigated by microbial biomass, soil respiration and DGGE of total and extracellular DNA

Abstract: We studied the distribution of the indigenous bacterial and fungal communities in a forest soil profile. The composition of bacterial and fungal communities was assessed by denaturing gradient gel electrophoresis (DGGE) of total and extracellular DNA extracted from all the soil horizons. Microbial biomass C and basal respiration were also measured to assess changes in both microbial biomass and activity throughout the soil profile. The 16S rDNA-DGGE revealed composite banding patterns reflecting the high bacterial diversity as expected for a forest soil, whereas 18S rDNA-DGGE analysis showed a certain stability and a lower diversity in the fungal communities. The banding patterns of the different horizons reflected changes in the microbial community structure with increasing depth. In particular, the DGGE analysis evidenced complex banding patterns for the upper A1 and A2 horizons, and a less diverse microflora in the deeper horizons. The low diversity and the presence of specific microbial communities in the B horizons, and in particular in the deeper ones, can be attributed to the selective environment represented by this portion of the soil profile. The eubacterial profiles obtained from the extracellular DNA revealed the presence of some bands not present in the total DNA patterns. This could be interpreted as the remainders of bacteria not any more present in the soil because of changes of edaphic conditions and consequent shifting in the microbial composition. These characteristic bands, present in all the horizons with the exception of the A1, should support the concept that the extracellular DNA is able to persist within the soil. Furthermore, the comparison between the total and extracellular 16S rDNA-DGGE profiles suggested a downwards movement of the extracellular DNA.

Selective laser sintering in biomedical engineering.

Abstract: Selective laser sintering (SLS) is a solid freeform fabrication technique, developed by Carl Deckard for his master’s thesis at the University of Texas, patented in 1989. SLS manufacturing is a technique that produces physical models through a selective solidification of a variety of fine powders. SLS technology is getting a great amount of attention in the clinical field. In this paper the characteristics features of SLS and the materials that have been developed for are reviewed together with a discussion on the principles of the above-mentioned manufacturing technique. The applications of SLS in tissue engineering, and at-large in the biomedical field, are reviewed and discussed.

An Overview of Current Research on Automated Essay Grading

Abstract: Introduction Assessment is considered to play a central role in the educational process. The interest in the development and in use of Computer-based Assessment Systems (CbAS) has grown exponentially in the last few years, due both to the increase of the number of students attending universities and to the possibilities provided by e-learning approaches to asynchronous and ubiquitous education. According to our findings (Valenti, Cucchiarelli, & Panti., 2002) more than forty commercial CbAS are currently available on the market. Most of those tools are based on the use of the so-called objective-type questions: i.e. multiple choice, multiple answer, short answer, selection/association, hot spot and visual identification (Valenti et al., 2000). Most researchers in this field agree on the thesis that some aspects of complex achievement are difficult to measure using objective-type questions. Learning outcomes implying the ability to recall, organize and integrate ideas, the ability to express oneself in writing and the ability to supply merely than identify interpretation and application of data, require less structuring of response than that imposed by objective test items (Gronlund, 1985). It is in the measurement of such outcomes, corresponding to the higher levels of the Bloom's (1956) taxonomy (namely evaluation and synthesis) that the essay question serves its most useful purpose. One of the difficulties of grading essays is the subjectivity, or at least the perceived subjectivity, of the grading process. Many researchers claim that the subjective nature of essay assessment leads to variation in grades awarded by different human assessors, which is perceived by students as a great source of unfairness. Furthermore essay grading is a time consuming activity. According to Mason (2002), about 30% of teachers' time in Great Britain is devoted to marking. "So, if we want to free up that 30% (worth 3 billion UK Pounds/year to the taxpayer by the way) then we must find an effective way, that teacher will trust, to mark essays and short text responses." This issue may be faced through the adoption of automated assessment tools for essays. A system for automated assessment would at least be consistent in the way it scores essays, and enormous cost and time savings could be achieved if the system can be shown to grade essays within the range of those awarded by human assessor. Furthermore, according to Hearst (2000) using computers to increase our understanding of the textual features and cognitive skills involved in the creation and in the comprehension of written texts, will provide a number of benefits to the educational community. In fact "it will help us develop more effective instructional materials for improving reading, writing and other communication abilities. It will also help us develop more effective technologies such as search engines and question answering systems for providing universal access to electronic information." Purpose of this paper is to present a survey of current approaches to the automated assessment of free text answers. Thus, in the next section, the following systems will be discussed: Project Essay Grade (PEG), Intelligent Essay Assessor (IEA), Educational Testing service I, Electronic Essay Rater (E-Rater), C-Rater, BETSY, Intelligent Essay Marking System, SEAR, Paperless School free text Marking Engine and Automark. All these systems are currently available either as commercial systems or as the result of research in this field. For each system, the general structure and the performance claimed by the authors are presented. In the last section, we will try to compare these systems and to identify issues that may foster the research in the field. Current Tools for Automated Essay Grading Project Essay Grade (PEG) PEG is one of the earliest and longest-lived implementations of automated essay grading. It was developed by Page and others (Hearst, 2000; Page, 1994, 1996) and primarily relies on style analysis of surface linguistic features of a block of text. …

The effect of coenzyme Q10 on morbidity and mortality in chronic heart failure: results from Q-SYMBIO: a randomized double-blind trial.

Abstract: Objectives This randomized controlled multicenter trial evaluated coenzyme Q10 (CoQ10) as adjunctive treatment in chronic heart failure (HF). Background CoQ10 is an essential cofactor for energy production and is also a powerful antioxidant. A low level of myocardial CoQ10 is related to the severity of HF. Previous randomized controlled trials of CoQ10 in HF were underpowered to address major clinical endpoints. Methods Patients with moderate to severe HF were randomly assigned in a 2-year prospective trial to either CoQ10 100 mg 3 times daily or placebo, in addition to standard therapy. The primary short-term endpoints at 16 weeks were changes in New York Heart Association (NYHA) functional classification, 6-min walk test, and levels of N-terminal pro–B type natriuretic peptide. The primary long-term endpoint at 2 years was composite major adverse cardiovascular events as determined by a time to first event analysis. Results A total of 420 patients were enrolled. There were no significant changes in short-term endpoints. The primary long-term endpoint was reached by 15% of the patients in the CoQ10 group versus 26% in the placebo group (hazard ratio: 0.50; 95% confidence interval: 0.32 to 0.80; p = 0.003) by intention-to-treat analysis. The following secondary endpoints were significantly lower in the CoQ10 group compared with the placebo group: cardiovascular mortality (9% vs. 16%, p = 0.026), all-cause mortality (10% vs. 18%, p = 0.018), and incidence of hospital stays for HF (p = 0.033). In addition, a significant improvement of NYHA class was found in the CoQ10 group after 2 years (p = 0.028). Conclusions Long-term CoQ10 treatment of patients with chronic HF is safe, improves symptoms, and reduces major adverse cardiovascular events. (Coenzyme Q10 as adjunctive treatment of chronic heart failure: a randomised, double-blind, multicentre trial with focus on SYMptoms, BIomarker status [Brain-Natriuretic Peptide (BNP)], and long-term Outcome [hospitalisations/mortality]; ISRCTN94506234 )