Marche Polytechnic University

About: Marche Polytechnic University is a education organization based out in Ancona, Italy. It is known for research contribution in the topics: Population & Cancer. The organization has 5905 authors who have published 15769 publications receiving 382286 citations. The organization is also known as: Universitá Politecnica delle Marche & Universita Politecnica delle Marche.

Does gender matter in bank–firm relationships? Evidence from small business lending

Abstract: In this paper we study the relevance of the gender of the contracting parties involved in lending. We show that female entrepreneurs face tighter credit availability, even though they do not pay higher interest rates. The effect is independent of the information available about the borrower and holds if we control for unobservable individual effects. The gender of the loan officer is also important: we find that female officers are more risk-averse or less self-confident than male officers as they tend to restrict credit availability to new, un-established borrowers more than their male counterparts.

Protocol for the examination of specimens from patients with carcinoma of the prostate gland.

Abstract: Authors John R. Srigley, MD, FCAP* Department of Laboratory Medicine, Credit Valley Hospital, Mississauga, Ontario, Canada Peter A. Humphrey, MD, PhD, FCAP* Department of Pathology, Washington University School of Medicine and Barnes-Jewish Hospital, St. Louis, Missouri Mahul B. Amin, MD, FCAP* Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, California Sam S. Chang, MD Department of Urologic Surgery, Vanderbilt-Ingram Cancer Center, Nashville, Tennessee Lars Egevad, MD Department of Pathology and Cytology, Karolinska University Hospital, Stockholm, Sweden Jonathan I. Epstein, MD Department of Pathology, Johns Hopkins Hospital, Baltimore, Maryland David J. Grignon, MD Department of Pathology, Indiana University School of Medicine, Indianapolis, Indiana James M. McKiernan, MD Columbia University College of Physicians and Surgeons, New York, New York Rodolfo Montironi, MD, FRCPath Institute of Pathological Anatomy and Histopathology, University of Ancona School of Medicine, Ancona, Italy Andrew A. Renshaw, MD Department of Pathology, Baptist Hospital of Miami, Miami, Florida Victor E. Reuter, MD Pathology Department, Memorial Sloan-Kettering Cancer Center, New York, New York Thomas M. Wheeler, MD, FCAP Department of Pathology and Immunology, Baylor College of Medicine, Houston, Texas Ming Zhou, MD, PhD, FCAP† Department of Pathology, New York University Langone Medical Center, New York, New York For the Members of the Cancer Committee, College of American Pathologists

Loss of CD127 Expression Defines an Expansion of Effector CD8+ T Cells in HIV-Infected Individuals

Abstract: The immunodeficiency that follows HIV infection is related to the virus-mediated killing of infected CD4(+) T cells, the chronic activation of the immune system, and the impairment of T cell production. In this study we show that in HIV-infected individuals the loss of IL-7R (CD127) expression defines the expansion of a subset of CD8(+) T cells, specific for HIV as well as other Ags, that show phenotypic (i.e., loss of CCR7 and CD62 ligand expression with enrichment in activated and/or proliferating cells) as well as functional (i.e., production of IFN-gamma, but not IL-2, decreased ex vivo proliferative potential and increased susceptibility to apoptosis) features of effector T cells. Importantly, in HIV-infected individuals the levels of CD8(+)CD127(-) T cells are directly correlated with the main markers of disease progression (i.e., plasma viremia and CD4(+) T cell depletion) as well as with the indices of overall T cell activation. In all, these results identify the expansion of CD8(+)CD127(-) effector-like T cells as a novel feature of the HIV-associated immune perturbation. Further studies are thus warranted to determine whether measurements of CD127 expression on CD8(+) T cells may be useful in the clinical management of HIV-infected individuals.