Institution
Rockefeller University
Education•New York, New York, United States•
About: Rockefeller University is a education organization based out in New York, New York, United States. It is known for research contribution in the topics: Population & Gene. The organization has 15867 authors who have published 32938 publications receiving 2940261 citations. The organization is also known as: Rockefeller University & Rockefeller Institute.
Topics: Population, Gene, Virus, Antigen, Receptor
Papers published on a yearly basis
Papers
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TL;DR: Some potential applications of these analogues in studies of the structure and function of nucleic acids and proteins are: analysis of protein-nucleic acid interaction, polynucleotide conformation and conformational transitions, enzyme-coenzyme interaction, and nuclease assay.
575 citations
TL;DR: A method is described for performing type-specific anti-M precipitin tests on group A hemolytic streptococci in 1 mm. capillary pipettes that now seems to be practical.
Abstract: A method is described for performing type-specific anti-M precipitin tests on group A hemolytic streptococci in 1 mm. capillary pipettes. These tests require so much less precipitating serum than was formerly used that the method now seems to be practical.
574 citations
TL;DR: The results show that the filter characteristics of striate cortical cells are not necessarily fixed, but can be dynamic, changing according to context, and this study modeled a neuronal ensemble encoding orientation.
574 citations
TL;DR: Intact Nef PxxP motifs are dispensable for Nef‐induced CD4 down‐regulation, but are required for the higher in vitro replicative potential of Nef+ viruses.
Abstract: Human immunodeficiency virus (HIV) and simian immunodeficiency virus Nef proteins contain a conserved motif with the minimal consensus (PxxP) site for Src homology region 3 (SH3)-mediated protein-protein interactions. Nef PxxP motifs show specific binding to biotinylated SH3 domains of Hck and Lyn, but not to those of other tested Src family kinases or less related proteins. A unique cooperative role of a distant proline is also observed. Endogenous Hck of monocytic U937 cells can be specifically precipitated by matrix-bound HIV-1 Nef, but not by mutant protein lacking PxxP. Intact Nef PxxP motifs are dispensable for Nef-induced CD4 down-regulation, but are required for the higher in vitro replicative potential of Nef+ viruses. Thus, CD4 down-regulation and promotion of viral growth are two distinct functions of Nef, and the latter is mediated via SH3 binding.
573 citations
TL;DR: It is proposed that BLBP is required for the establishment of the radial glial fiber system in developing brain, a system that is necessary for the migration of immature neurons to establish cortical layers.
572 citations
Authors
Showing all 15925 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Bruce S. McEwen | 215 | 1163 | 200638 |
| David Baltimore | 203 | 876 | 162955 |
| Ronald M. Evans | 199 | 708 | 166722 |
| Lewis C. Cantley | 196 | 748 | 169037 |
| Ronald Klein | 194 | 1305 | 149140 |
| Scott M. Grundy | 187 | 841 | 231821 |
| Jie Zhang | 178 | 4857 | 221720 |
| Andrea Bocci | 172 | 2402 | 176461 |
| Ralph M. Steinman | 171 | 453 | 121518 |
| Masayuki Yamamoto | 171 | 1576 | 123028 |
| Zena Werb | 168 | 473 | 122629 |
| Nahum Sonenberg | 167 | 647 | 104053 |
| Michel C. Nussenzweig | 165 | 516 | 87665 |
| Harvey F. Lodish | 165 | 782 | 101124 |
| Dennis R. Burton | 164 | 683 | 90959 |