Institution
Rockefeller University
Education•New York, New York, United States•
About: Rockefeller University is a education organization based out in New York, New York, United States. It is known for research contribution in the topics: Population & Gene. The organization has 15867 authors who have published 32938 publications receiving 2940261 citations. The organization is also known as: Rockefeller University & Rockefeller Institute.
Topics: Population, Gene, Virus, Antigen, Receptor
Papers published on a yearly basis
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TL;DR: This genetically targeted translating ribosome affinity purification (TRAP) methodology is a generalizable method useful for the identification of molecular changes in any genetically defined cell type in response to genetic alterations, disease, or pharmacological perturbations.
1,050 citations
TL;DR: A rapid and sensitive method for the quantitative determination of free amino groups during solid-phase peptide synthesis has been developed and is useful for measuring the total number of peptide chains on the resin and, especially, for monitoring the progress of the coupling reaction.
1,047 citations
TL;DR: Thalidomide inhibition of lipopolysaccharide-induced tumor necrosis factor alpha production is examined and it is found that the drug enhances the degradation of TNF-alpha mRNA, providing an explanation for the synergistic effects of these drugs.
Abstract: We have examined the mechanism of thalidomide inhibition of lipopolysaccharide (LPS)-induced tumor necrosis factor alpha (TNF-alpha) production and found that the drug enhances the degradation of TNF-alpha mRNA. Thus, the half-life of the molecule was reduced from approximately 30 to approximately 17 min in the presence of 50 micrograms/ml of thalidomide. Inhibition of TNF-alpha production was selective, as other LPS-induced monocyte cytokines were unaffected. Pentoxifylline and dexamethasone, two other inhibitors of TNF-alpha production, are known to exert their effects by means of different mechanisms, suggesting that the three agents inhibit TNF-alpha synthesis at distinct points of the cytokine biosynthetic pathway. These observations provide an explanation for the synergistic effects of these drugs. The selective inhibition of TNF-alpha production makes thalidomide an ideal candidate for the treatment of inflammatory conditions where TNF-alpha-induced toxicities are observed and where immunity must remain intact.
1,046 citations
TL;DR: It is found that B cell division is restricted to the DZ, with a net vector of B cell movement from the D Z to the LZ, and T cell help, and not direct competition for antigen, is the limiting factor in GC selection.
1,045 citations
TL;DR: Dissociation rate measurements indicate a cooperative interaction between USF and TFIID when simultaneously bound to the promoter DNA.
1,043 citations
Authors
Showing all 15925 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Bruce S. McEwen | 215 | 1163 | 200638 |
| David Baltimore | 203 | 876 | 162955 |
| Ronald M. Evans | 199 | 708 | 166722 |
| Lewis C. Cantley | 196 | 748 | 169037 |
| Ronald Klein | 194 | 1305 | 149140 |
| Scott M. Grundy | 187 | 841 | 231821 |
| Jie Zhang | 178 | 4857 | 221720 |
| Andrea Bocci | 172 | 2402 | 176461 |
| Ralph M. Steinman | 171 | 453 | 121518 |
| Masayuki Yamamoto | 171 | 1576 | 123028 |
| Zena Werb | 168 | 473 | 122629 |
| Nahum Sonenberg | 167 | 647 | 104053 |
| Michel C. Nussenzweig | 165 | 516 | 87665 |
| Harvey F. Lodish | 165 | 782 | 101124 |
| Dennis R. Burton | 164 | 683 | 90959 |