Institution
Rockefeller University
Education•New York, New York, United States•
About: Rockefeller University is a education organization based out in New York, New York, United States. It is known for research contribution in the topics: Population & Gene. The organization has 15867 authors who have published 32938 publications receiving 2940261 citations. The organization is also known as: Rockefeller University & Rockefeller Institute.
Topics: Population, Gene, Virus, Antigen, Receptor
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TL;DR: The DNA binding subunit of the transcription factor NF-kappa B, p50, has been cloned and sequence analysis reveals remarkable homology for over 300 amino acids at the amino-terminal end to the oncogene v-rel, its cellular homolog c-rel and the Drosophila maternal effect gene dorsal as mentioned in this paper.
762 citations
TL;DR: It is shown that inhibitory signalling by FcγRIIB does not require the SH2-domain-containing protein tyrosine phosphatase, SHP-1, in mast cells and results in the recruitment of the SH1- domain-containing inositol polyphosphate 5-phosphatase to the tyrosinesine- phosphorylated 13-amino-acid inhibitory motif of FcβB in both B cells and mast cells.
Abstract: Immune complexes are potent activators of inflammatory cells, triggering effector responses through the crosslinking of Fc receptors (FcRs) such as Fc(epsilon)RI or Fc(gamma)RIII. On B cells and mast cells, immune complexes are also negative regulators of activation triggered by antigen and Fc receptors, a consequence of coligation of the B-cell antigen receptor or Fc(epsilon)RI, respectively, and the inhibitory receptor Fc(gamma)RIIB. Here we show that inhibitory signalling by Fc(gamma)RIIB does not require the SH2-domain-containing protein tyrosine phosphatase, SHP-1, in mast cells and results in the recruitment of the SH2-domain-containing inositol polyphosphate 5-phosphatase, SHIP, to the tyrosine-phosphorylated 13-amino-acid inhibitory motif of Fc(gamma)RIIB in both B cells and mast cells. SHIP, by hydrolysing the 5-phosphate of phosphatidylinositol(3,4,5)P3 and inositol(1,3,4,5)P4, suggests a mechanism by which Fc(gamma)RIIB can inhibit calcium influx and downstream responses triggered by immune receptors.
758 citations
TL;DR: Findings link TNC to pathways that support the fitness of metastasis-initiating breast cancer cells and highlight the relevance of TNC as an extracellular matrix protein of stem cell niches of the metastatic niche.
Abstract: Tenascin C is an extracellular matrix protein previously linked to breast cancer metastasis. Here the authors uncover how tenascin C promotes the fitness of metastasis-initiating cells by sustaining the stem and survival signaling pathways NOTCH and Wnt through specific regulation of Msi1 and Lgr5, respectively.
758 citations
TL;DR: In this paper, the effects of behavioral stress on the medial prefrontal cortex (mPFC) were investigated using the repeated restraint stress paradigm, and cellular reconstructions were performed on apical and basal dendrites of pyramidal neurons in the anterior cingulate and prelimbic cortices.
753 citations
TL;DR: It is shown that 2'-O-methyl oligoribonucleotides, but not 2'-deoxyoligon nucleotides specifically inactivate the RNAi activity associated with miRNA-protein complexes in human cell extracts as well as in cultured human cells.
Abstract: A large number of miRNAs have recently been discovered in plants and animals. Development of reverse genetic approaches that act to inhibit microRNA function would facilitate the study of this new class of noncoding RNA. Here we show that 2'-O-methyl oligoribonucleotides, but not 2'-deoxyoligonucleotides specifically inactivate the RNAi activity associated with miRNA-protein complexes in human cell extracts as well as in cultured human cells.
752 citations
Authors
Showing all 15925 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Bruce S. McEwen | 215 | 1163 | 200638 |
| David Baltimore | 203 | 876 | 162955 |
| Ronald M. Evans | 199 | 708 | 166722 |
| Lewis C. Cantley | 196 | 748 | 169037 |
| Ronald Klein | 194 | 1305 | 149140 |
| Scott M. Grundy | 187 | 841 | 231821 |
| Jie Zhang | 178 | 4857 | 221720 |
| Andrea Bocci | 172 | 2402 | 176461 |
| Ralph M. Steinman | 171 | 453 | 121518 |
| Masayuki Yamamoto | 171 | 1576 | 123028 |
| Zena Werb | 168 | 473 | 122629 |
| Nahum Sonenberg | 167 | 647 | 104053 |
| Michel C. Nussenzweig | 165 | 516 | 87665 |
| Harvey F. Lodish | 165 | 782 | 101124 |
| Dennis R. Burton | 164 | 683 | 90959 |