Roussel Uclaf

About: Roussel Uclaf is a based out in . It is known for research contribution in the topics: Alkyl & Alkoxy group. The organization has 1888 authors who have published 2338 publications receiving 36508 citations.

Triazoloquinazolones and their salts, process and intermediates for preparing them, their use as medicines and compositions containing them

Abstract: L'invention concerne les triazoloquinazolones The invention relates triazoloquinazolones ou R et R' sont hydrogene, halogene, alcoyle ou alcoxy (1 a 3 carbones) et nitro, Y est alcoyle (1 a 6 carbones), cycloalcoyle (3 a 8 carbones), alcenyle (2 a 4 carbones), aryle ou aralcoyle (6 a 8 carbones), B est wherein R and R 'are hydrogen, halogen, alkyl or alkoxy (1-3 carbons) and nitro, Y is alkyl (1 to 6 carbons), cycloalkyl (3 to 8 carbons), alkenyl (2-4 carbons), aryl or aralkyl (6 to 8 carbons), B is ou alcoylene -(CH 2 )n- ou n est 1, 2 ou 3, alkylene or - (CH 2) n- wherein n is 1, 2 or 3, ou R 1 et R 2 sont hydrogene, alcoyle (1 a 6 carbones), cycloalcoyle (3 a 8 carbones), aryle ou aralcoyle (6 a 8 carbones), aminoalcoyle, monoalcoyle ou dialcoylaminoalcoyle (alcoyles de 2 a 4 carbones, piperidinoalcoyle, morpholinoalcoyle ou piperazinylalcoyle, ou R, et R 2 forment avec l'azote un heteroxycle sature mono ou bicyclique (4 a 8 carbones), pouvant porter 1 ou 2 methyles, ou renfermer un oxygene, un soufre ou un azote qui peut etre substitue par alcoyle (1 a 3 carbones), hydroxyalcoyle (1 a 3 carbones), aryl ou aralcoyle (6 a 8 carbones) ou alcoxycarbonyle (2 a 5 carbones) ou X est wherein R 1 and R 2 are hydrogen, alkyl (1 to 6 carbons), cycloalkyl (3 to 8 carbons), aryl, or aralkyl (6 to 8 carbons), aminoalkyl, monoalkyl or dialkylaminoalkyl (alkyl from 2 to 4 carbons, piperidinoalcoyle, morpholinoalcoyle or piperazinylalcoyle, or R, and R 2 form with the nitrogen a saturated mono or bicyclic heteroxycle (4-8 carbons), which may have 1 or 2 methyl or contain oxygen, sulfur or nitrogen which may be substituted by alkyl (1-3 carbons), hydroxyalkyl (1-3 carbons), aryl or aralkyl group (6-8 carbons) or alkoxycarbonyl (2 to 5 carbons) or X is leurs sels avec les acides, leur preparation, leur application comme medicaments notamment antihistaminiques et bronchospasmolytiques. salts with acids, their preparation, their use as medicaments including antihistamines and bronchospasmolytic. les compositions les renfermant et des intermediaires nouveaux. compositions containing them and novel intermediates.

2-Amino-4-thiazolyl-2-oxyimino-acetamido-bicyclooctene-carboxylic acids

Abstract: Novel syn isomers of optically active isomers and racemates of 7-[2-(2-amino-4-thiazolyl)-2-oxyimino-acetamido]-bicyclooctene-carboxylic acid derivatives of the formula ##STR1## wherein R is selected from the group consisting of hydrogen, optionally substituted alkyl of 1 to 6 carbon atoms and optionally substituted alkenyl and alkynyl of 2 to 6 carbon atoms, R 1 is selected from the group consisting of hydrogen, methyl, halomethyl, hydroxymethyl and acyloxymethyl, X is selected from the group consisting of oxygen and optionally oxidized sulfur, A is selected from the group consisting of hydrogen, an alkali metal, --NH 4 , alkaline earth metal equivalent, a non-toxic, pharmaceutically acceptable organic amine and an easily cleavable ester group and their non-toxic, pharmaceutically acceptable acid addition salts having antibiotic activity and their preparation.

2-cyano-3-hydroxy-enamides

Abstract: A compound selected from the group consisting of a compound of the formula ##STR1## wherein R 1 is selected from the group consisting of ##STR2## R 13 , R 14 and R 15 are individually selected from the group consisting of hydrogen, halogen and alkyl of 1 to 3 carbon atoms, n is an integer from 1 to 3, R 2 is hydrogen or alkyl of 1 to 3 carbon atoms, R 3 , R 4 R 5 , R 6 and R 7 are individually selected from the group consisting of hydrogen, halogen, --NO 2 , --CN, alkyl, alkylthio and alkoxy of 1 to 6 carbon atoms, alkylcarbonyl of 2 to 6 carbon atoms, cycloalkyl of 3 to 6 carbon atoms, ##STR3## m is 0, 1, 2 or 3, n is 1, 2 or 3; Hal, Hal 1 , Hal 2 and Hal 3 are individually halogen and ##STR4## R 8 , R 9 , R 10 , R 11 and R 12 are individually any of the groups defined above for R 3 , R 4 , R 5 , R 6 and R 7 or R 4 and R 5 together form --O--CH 2 --O-- and their non-toxic, pharmaceutically acceptable base addition salts having anti-inflammatory activity.