Institution
Roussel Uclaf
About: Roussel Uclaf is a based out in . It is known for research contribution in the topics: Alkyl & Alkoxy group. The organization has 1888 authors who have published 2338 publications receiving 36508 citations.
Topics: Alkyl, Alkoxy group, Aryl, Carbon, Carboxylic acid
Papers published on a yearly basis
Papers
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TL;DR: The Reaktionenkartei des Dokumentationsringes der chemisch-pharmazeutischen Industrie arbeitet with Lochkarten.
Abstract: Die Reaktionenkartei des Dokumentationsringes der chemisch-pharmazeutischen Industrie arbeitet mit Lochkarten. Ausgangs- und Endprodukt werden mit einem Fragment-Code verschlusselt, desgleichen werden die bei der Reaktion veranderten Bindungen notiert. Hilfsstoffe und physikalische Daten lassen sich ebenfalls einspeichern. Bei mehrstufigen Reaktionen werden sowohl die einzelnen Schritte als auch mehrere Stufen gleichzeitig registriert.
8 citations
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TL;DR: The results show that culturing rabbit proximal kidney tubule cells on collagen IV-coated porous membranes was accompanied by an improvement of both morphological and biochemical properties of the cells.
Abstract: The aim of this study was to better characterize rabbit proximal kidney tubule cells cultured on collagen IV-coated porous inserts, as compared to the same cells seeded in standard plastic wells. Total protein contents in confluent monolayers on permeable membranes were about twofold higher than those measured in confluent cultures in plastic wells. Microscopy examinations suggested that such a difference was probably due to a higher cell density and to an impressive development of the apical brush-border membrane. Moreover, measurement of unidirectional transport of p-aminohippuric acid and tetraethylammonium bromide confirmed the high polarization level of cultures on porous inserts. Results of methyl(α-d-[U-14C]glyco)pyranoside uptake suggested that cell phenotype was probably influenced by culture conditions. Analysis of different markers as a function of time in culture showed decreases of alkaline phosphatase (AP), γ-glutamyltranspeptidase (GGT), and Na+-K+-ATPase activities as well as increases in LDH, ATP, and glutathione levels, similar to those formerly reported for cells cultured in standard plastic plates. However, comparative data from 6-d-old monolayers have shown that AP, GGT, Na+-K+-ATPase, glutathione reductase (GRED), and selenium-dependent glutathione peroxidase (Se-GPX) activities were 2.8-, 2.6-, 1.6-, 1.2-, and 2.1-fold, respectively, better preserved on precoated permeable membranes. On the other hand, this paper reports for the first time in the literature that GRED and Se-GPX, two phase II detoxification enzymes, were well maintained in cultures of rabbit proximal kidney tubule cells. Our results show that culturing rabbit proximal kidney tubule cells on collagen IV-coated porous membranes was accompanied by an improvement of both morphological and biochemical properties of the cells.
8 citations
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TL;DR: Fluorescent spirolactone derivatives are obtained by coupling 3-carboxylic coumarins to a spirollactone bearing a 3-hydroxypropyl chain in the 7 alpha position.
8 citations
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26 Jul 1989TL;DR: In this article, a nonglycosylated, recombinant human IL2 in which the three cysteines in positions 58, 105 and 125 are in the reduced form and which exhibits a biological activity comparable with that of the oxidised IL2 having the same sequence and containing a disulphide bridge in position 58-105, was described.
Abstract: The invention relates to a nonglycosylated, recombinant human IL2 in which the three cysteines in positions 58, 105 and 125 are in the reduced form and which exhibits a biological activity comparable with that of the oxidised IL2 having the same sequence and containing a disulphide bridge in position 58-105, to the process for obtaining it and to its application as a medication.
8 citations
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TL;DR: In this article, structural comparisons between the classical electron transport inhibitor rotenone and other compounds with a similar mode of action have been made and a new set of inhibitors has been designed and synthesized which relate to rotonone but lack the core B/C ring structure previously considered of major significance.
8 citations
Authors
Showing all 1888 results
Name | H-index | Papers | Citations |
---|---|---|---|
Fernand Labrie | 110 | 885 | 48308 |
Lionel H. Opie | 84 | 519 | 25964 |
Alain Bélanger | 70 | 244 | 16469 |
Michel J. Tremblay | 53 | 273 | 10485 |
Pierre Monsan | 51 | 216 | 8049 |
Samir Z. Zard | 50 | 575 | 10739 |
Alejandro Aruffo | 47 | 123 | 14084 |
Samuel S.C. Yen | 47 | 96 | 6865 |
Dominique Maraninchi | 47 | 188 | 8108 |
Serge Erlinger | 46 | 152 | 8200 |
Romain Lefebvre | 40 | 221 | 5269 |
William B. Motherwell | 39 | 305 | 6357 |
Jean-Pierre Raynaud | 38 | 104 | 5075 |
André Lemay | 38 | 114 | 4264 |
Patrick J. Creaven | 32 | 102 | 3435 |