Institution
Roussel Uclaf
About: Roussel Uclaf is a based out in . It is known for research contribution in the topics: Alkyl & Alkoxy group. The organization has 1888 authors who have published 2338 publications receiving 36508 citations.
Topics: Alkyl, Alkoxy group, Aryl, Carbon, Carboxylic acid
Papers published on a yearly basis
Papers
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TL;DR: Demethylation of methylthio imidazole 1 via a Pummerer rearrangement onto the corresponding sulfoxide 2 afforded imidaze thiol 4 which was then difluoromethylated with the sodium chlorodifluoroacetate/NaI system in 71% overall yield as mentioned in this paper.
17 citations
Patent•
09 Oct 1987TL;DR: In this article, substituents on the D-ring of 9-alpha-hydroxy-androst-4-α-hydroxene-3,17-dione were introduced for the purpose of synthesizing new 9-α,hydroxy steroids, which are useful intermediates in the synthesis of corticosteroids.
Abstract: New 9-alpha-hydroxy steroids are prepared by the introduction of substituents on the D-ring of 9-alpha-hydroxy-androst-4-ene-3,17-dione.
The resulting compounds are useful intermediates in the synthesis of corticosteroids.
17 citations
TL;DR: Kinetics in single dosed animals showed that the duration of RU 25591 food intake depression was shorter than in vivo serotonin uptake inhibition, and in repeated dosing treatment a progressive time- related decrease in the inhibition of food consumption was observed.
17 citations
Patent•
22 Aug 1990TL;DR: In this article, the authors defined compositions which contain zinc oxide and one or more anti-enzymes, and defined the following classes of compositions: 1) Pharmaceutical compositions containing zinc oxide.
Abstract: of EP0414605Pharmaceutical compositions which contain zinc oxide and one or more anti-enzymes.
17 citations
TL;DR: The potent localized inhibition of sebaceous glands by RU 58841 demonstrates the excellent potential of this compound as a topical drug for the treatment of acne and other androgen-mediated disorders.
Abstract: The biological activity of a series of nonsteroidal, pure androgen receptor inhibitors was compared using the Syrian hamster ear skin sebaceous gland model. RU 58841, RU 56187, RU 38882 and cyproterone acetate were applied topically for 4 weeks on the ventral ear pinna of sexually mature male Syrian hamsters. Their order of efficacy was as follows: RU 58841 > RU 56187 > RU 38882 > cyproterone acetate. Maximal reduction of 60% in the size of the sebaceous glands was observed in hamsters treated with RU 58841 at a dose of 10 micrograms per day. This degree of inhibition occurred without any systemic side effects as shown by the absence of inhibition on the contralateral untreated ear pinna. Longer treatment did not produce greater inhibition since extending the treatment period from 4 weeks to 12 weeks showed similar data. The effect of RU 58841 was reversible since the inhibited sebaceous glands returned to normal size within 4 weeks after the cessation of the topical applications. The potent localized inhibition of sebaceous glands by RU 58841 demonstrates the excellent potential of this compound as a topical drug for the treatment of acne and other androgen-mediated disorders.
17 citations
Authors
Showing all 1888 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Fernand Labrie | 110 | 885 | 48308 |
| Lionel H. Opie | 84 | 519 | 25964 |
| Alain Bélanger | 70 | 244 | 16469 |
| Michel J. Tremblay | 53 | 273 | 10485 |
| Pierre Monsan | 51 | 216 | 8049 |
| Samir Z. Zard | 50 | 575 | 10739 |
| Alejandro Aruffo | 47 | 123 | 14084 |
| Samuel S.C. Yen | 47 | 96 | 6865 |
| Dominique Maraninchi | 47 | 188 | 8108 |
| Serge Erlinger | 46 | 152 | 8200 |
| Romain Lefebvre | 40 | 221 | 5269 |
| William B. Motherwell | 39 | 305 | 6357 |
| Jean-Pierre Raynaud | 38 | 104 | 5075 |
| André Lemay | 38 | 114 | 4264 |
| Patrick J. Creaven | 32 | 102 | 3435 |