Institution
Roussel Uclaf
About: Roussel Uclaf is a based out in . It is known for research contribution in the topics: Alkyl & Alkoxy group. The organization has 1888 authors who have published 2338 publications receiving 36508 citations.
Topics: Alkyl, Alkoxy group, Aryl, Carbon, Carboxylic acid
Papers published on a yearly basis
Papers
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TL;DR: The current article summarizes the contributions to a symposium on pathophysiology and treatment of water retention in cirrhosis organized by the International Ascites Club and held at the Palexpo Center in Geneva, Switzerland, on August 25, 1996.
266 citations
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TL;DR: The complete amino acid sequence of human preprocalcitonin could be deduced and an insert stimulating synthesis of the protein and containing restriction sites compatible with the previously published complete sequence of calcitonin mRNA from rat was sequenced.
244 citations
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TL;DR: The interaction of estradiol and testosterone with rat plasma proteins has been studied by equilibrium dialysis, sucrose gradient centrifugation, column chromatography and polyacrylamide gel electrophoresis, finding that Estradiol Binding Plasma Protein, unlike several synthetic estrogens, is bound with greater affinity, whereas non estrogenic steroids including testosterone are not bound at all.
242 citations
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TL;DR: Preliminary data obtained in patients with cancer of the prostrate show inhibition of both testosterone and dihydrotestosterone plasma levels with a temporary loss of diurnal cyclicity, suggesting the potential use of LHRH agonists in male contraception and for the treatment of cancer ofThe prostrate.
Abstract: Acute or chronic treatment of adult male rats with luteinizing hormone-releasing hormone (LHRH) or its agonist leads to a loss of testicular LH and prolaction receptors accompanied by decreased testis seminal vesicle and ventral prostate weight. The inhibition of testosterone formation is due to a blockage of the steroidogenic pathway at the level of 17-hydroxylase and 1720-desmolase activities. The testicular desensitization is accompanied by a decreased pituitary responsiveness LHRH. Although the inhibitory effects at the testicular level could be explained by endogenous LH release induced by the LHRH agonist with secondary testicular desentization the LH-relasing peptides also exert direct inhibitory effects on gonadotropin receptors at the testicular level. Moreover LHRH and its agonists bind to a specific LHRH receptor in interstitial cells. Chronic treatment with LH agonists leads to marked degenerative changes in the seminiferous tubules almost all tubules showing signs of histologic damage after 4 weeks of treatment. Single administration of an LHRH agonist by the intranasal route in normal adult men casuses a transient inhibition of plasma testosterone levels with a temporary loss of diurnal cyclicity whereas preliminary data obtained in patients with cancer of the prostrate show inhibition of both testosterone and dihydrotestosterone plasma levels. Such data suggest the potential use of LHRH agonists in male contraception and for the treatment of cancer of the prostrate. (authors)
228 citations
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TL;DR: Methyltrienolone (R 1881), 17beta-hydroxy-17alpha-methyl-estra-4,9,11-trien-3-one, a very active androgen, binds specifically to rat prostate cytosol with a higher affinity than androstanolone, and is thus a useful tool for the detection of elusive androgen receptors and for their study in human tumors where interference from plasma contamination has to be circumvented.
207 citations
Authors
Showing all 1888 results
Name | H-index | Papers | Citations |
---|---|---|---|
Fernand Labrie | 110 | 885 | 48308 |
Lionel H. Opie | 84 | 519 | 25964 |
Alain Bélanger | 70 | 244 | 16469 |
Michel J. Tremblay | 53 | 273 | 10485 |
Pierre Monsan | 51 | 216 | 8049 |
Samir Z. Zard | 50 | 575 | 10739 |
Alejandro Aruffo | 47 | 123 | 14084 |
Samuel S.C. Yen | 47 | 96 | 6865 |
Dominique Maraninchi | 47 | 188 | 8108 |
Serge Erlinger | 46 | 152 | 8200 |
Romain Lefebvre | 40 | 221 | 5269 |
William B. Motherwell | 39 | 305 | 6357 |
Jean-Pierre Raynaud | 38 | 104 | 5075 |
André Lemay | 38 | 114 | 4264 |
Patrick J. Creaven | 32 | 102 | 3435 |