Institution
Roussel Uclaf
About: Roussel Uclaf is a based out in . It is known for research contribution in the topics: Alkyl & Alkoxy group. The organization has 1888 authors who have published 2338 publications receiving 36508 citations.
Topics: Alkyl, Alkoxy group, Aryl, Carbon, Carboxylic acid
Papers published on a yearly basis
Papers
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22 Mar 19788 citations
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TL;DR: Results indicate that trandolapril is a more potent (by a factor of about 30) inhibitor of ACE than enalapril and causes a greater degree of regression of cardiac hypertrophy.
Abstract: The dose-related effects of trandolapril on serum angiotensin-converting enzyme (ACE) activity, blood pressure and cardiac hypertrophy were studied after 2-week oral treatment in adult spontaneously hypertensive rats. Trandolapril caused a dose-dependent decrease in mean blood pressure at doses of 0.03-3 mg/kg. Inhibition of serum ACE was demonstrated by even the lowest dose (-9% at 0.003 mg/kg), was about 40% at 0.03 mg/kg, and rose to 84% at 3 mg/kg. Regression of cardiac hypertrophy (heart:body weight) was seen at doses of trandolapril as low as 0.03 mg/kg (-5.1%), which was also the minimal effective antihypertensive dose. Clear dose-response curves were observed for trandolapril from 0.03 mg/kg upwards with respect to hypotensive effect and regression of cardiac hypertrophy, which were not seen with enalapril. Enalapril had no significant effect on plasma ACE activity except at the highest dose (10 mg/kg), despite demonstrating hypotensive effects with smaller doses. These results indicate that trandolapril is a more potent (by a factor of about 30) inhibitor of ACE than enalapril (only 34% inhibition at 10 mg/kg) and causes a greater degree of regression of cardiac hypertrophy.
8 citations
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13 Apr 1992TL;DR: A method of treating ovarian cancer in warm-blooded animals comprising intraperitoneally administering to warmblooded animals by perfusion a recombinant polypeptide of human gamma interferon type with a specific activity at least equal to 1×10 7 U/mg in an anti-cancer effective amount is described in this article.
Abstract: A method of treating ovarian cancer in warm-blooded animals comprising intraperitoneally administering to warm-blooded animals by perfusion a recombinant polypeptide of human gamma interferon type with a specific activity at least equal to 1×10 7 U/mg in an anti-cancer effective amount
8 citations
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TL;DR: In this article, the steric course of the 1,4-opening of cisoid and transoid diene monooxide incorporated in mono or polycyclic structures is analyzed and the stereochemistry of the reverse reaction corresponding to diene polyoxide formation from a γ-bromo-α,β-unsaturated-cyclohexanol can also be predicted.
8 citations
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TL;DR: Daily administration of increasing doses of R2323, a compound with antiprogestin activity, caused a progressive inhibition of tumor development, and there was no significant change of receptor levels for estradiol, progesterone or prolactin in tumor tissue nor of plasma Prolactin concentrations, whereas plasma LH levels were markedly decreased after R23 23 treatment.
8 citations
Authors
Showing all 1888 results
Name | H-index | Papers | Citations |
---|---|---|---|
Fernand Labrie | 110 | 885 | 48308 |
Lionel H. Opie | 84 | 519 | 25964 |
Alain Bélanger | 70 | 244 | 16469 |
Michel J. Tremblay | 53 | 273 | 10485 |
Pierre Monsan | 51 | 216 | 8049 |
Samir Z. Zard | 50 | 575 | 10739 |
Alejandro Aruffo | 47 | 123 | 14084 |
Samuel S.C. Yen | 47 | 96 | 6865 |
Dominique Maraninchi | 47 | 188 | 8108 |
Serge Erlinger | 46 | 152 | 8200 |
Romain Lefebvre | 40 | 221 | 5269 |
William B. Motherwell | 39 | 305 | 6357 |
Jean-Pierre Raynaud | 38 | 104 | 5075 |
André Lemay | 38 | 114 | 4264 |
Patrick J. Creaven | 32 | 102 | 3435 |