Roussel Uclaf

About: Roussel Uclaf is a based out in . It is known for research contribution in the topics: Alkyl & Alkoxy group. The organization has 1888 authors who have published 2338 publications receiving 36508 citations.

Certain azaspirodecane compounds and a method of inducing an anxiolytic activity

Abstract: A compound selected from the group consisting of azaspirodecane derivatives of the formula ##STR1## wherein R is selected from the group consisting of hydrogen, fluorine, chlorine, bromine, alkoxy of 1 to 3 carbon atoms, --NO2, --NH2 and CH3 S-- in the 4,5 or 6 position of the ring, R' is oxo or hydrogen or --OH or alkyl of 1 to 3 carbon atoms and the dotted line indicates a carbon-carbon bond in the 2,3-position, n is 2,3,4 or 5 and the dotted line in the piperidyl ring is an optional carbon-carbon bond and their non-toxic, pharmaceutically acceptable acid addition salts having remarkable anxiolytic activity.

Phenyl carboxamide isoxazoles

Abstract: A compound selected from the group consisting of a compound of the formula ##STR1## wherein R 1 is hydrogen or alkyl of 1 to 3 carbon atoms, R 2 is alkyl of 1 to 3 carbon atoms or cycloalkyl of 3 to 6 carbon atoms, R 3 is --COOR 6 , R 6 is hydrogen or alkyl of 1 to 3 carbon atoms, R 4 is selected from the group consisting of halogen, --CN, --NO 2 , --SCH 3 , alkylcarbonyl of 1 to 6 alkyl carbon atoms, --CX 3 , --WCX 3 , --(CH 2 ) n --CX 3 , --(CX 2 ) n --CX 3 , --W--(CX 2 ) n --CX 3 , and --W--(CH 2 ) n --CX 3 , X is halogen, W is --O-- or --S--, n is 1, 2 or 3, R 5 is selected from the group consisting of hydrogen, alkyl of 1 to 3 carbon atoms and cycloalkyl of 3 to 6 carbon atoms and their salts with non-toxic pharmaceutically acceptable bases with the proviso that if R 2 is alkyl of 1 to 3 carbon atoms, R 1 is hydrogen and R 4 is selected from the group consisting of halogen, --CX 3 , --(CH 2 ) n --CX 3 , --(CX 2 ) n --CX 3 , --OCX 3 , --O--(CX 2 ) n --CX 3 , and --O--(CH 2 ) n --CX 3 , X is halogen and n is 1, 2 or 3, R 5 cannot be hydrogen having anti-inflammatory activity and their preparation and intermediates.

7-Amino-benzocycloheptenes

Abstract: Novel 7-amino-benzocycloheptenes of the formula ##STR1## wherein X is selected from the group consisting of hydrogen, chlorine, bromine and iodine in the 2- or 4-position when a halogen, Y and Z are hydrogen or together form a double bond, R is selected from the group consisting of hydrogen, alkyl of 1 to 5 carbon atoms and phenyl optionally substituted with fluorine, chlorine, methyl or methoxy, R 1 is selected from the group consisting of hydrogen, alkyl of 1 to 5 carbon atoms and alkenyl of 2 to 5 carbon atoms and R 2 is selected from the group consisting of alkyl of 1 to 5 carbon atoms and alkenyl of 2 to 5 carbon atoms and R 1 and R 2 taken together with the nitrogen atom to which they are attached form a saturated heterocycle of 4 to 6 carbon atoms and optionally containing another hetero-atom and optionally substituted with an alkyl of 1 to 5 carbon atoms and their non-toxic, pharmaceutically acceptable acid addition salts having antidepressive activity and their preparation and novel intermediates.

A System for the Documentation of Chemical Reactions

Abstract: The Documentation Ring of the chemical and pharmaceutical industries uses a punched card system to record chemical reactions. The starting materials and the end products are encoded with a fragmentation code, and the bonds that change during the reaction are recorded in the same way. Reaction modifiers and physical data can also be stored. In the case of multistage reactions, both the individual stages and various groups of stages are recorded.