Institution
Roussel Uclaf
About: Roussel Uclaf is a based out in . It is known for research contribution in the topics: Alkyl & Alkoxy group. The organization has 1888 authors who have published 2338 publications receiving 36508 citations.
Topics: Alkyl, Alkoxy group, Aryl, Carbon, Carboxylic acid
Papers published on a yearly basis
Papers
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TL;DR: Scatchard analysis of [3H]-aldosterone binding in the presence of RU 26988 showed that the mineralocorticoid receptors present in these different structures have approximately the same affinity (KD = 3.10−9 M) for aldosterone.
190 citations
TL;DR: By exchanging bound endogenous hormone in rat prostate cytosol with labelled R 1881, it is possible to measure total (free anc occupied) binding sites in androgen receptor sites in human benign prostatic hypertrophy.
185 citations
TL;DR: Monoclonal antibody production kinetics in batch systems is linearly related to the integral of the viable cells curve, which favors the secretion theory over that of release by dead cells.
Abstract: Monoclonal antibody production kinetics in batch systems is linearly related to the integral of the viable cells curve. This favors the secretion theory over that of release by dead cells. Regression of the production curve over the integral of the viable cells curve in different media can also give information on the nutritional requirements of the cells for growth and production.
182 citations
TL;DR: In this paper, the authors examined endocrine and clinical responses to long-term administration of RU486 in patients with endometriosis and found that daily administration of the drug resulted in acyclic ovarian function and improvement in subjective painful symptoms of endometriumosis.
181 citations
TL;DR: Evidence is presented that PBP2a and PBP1b also appear to be low-affinity variants and are encoded by distinct alleles in beta-lactam-resistant transformants of S. pneumoniae obtained with chromosomal donor DNA from a Streptococcus mitis isolate.
Abstract: Penicillin-resistant isolates of Streptococcus pneumoniae generally contain mosaic genes encoding the low-affinity penicillin-binding proteins (PBPs) PBP2x, PBP2b, and PBP1a. We now present evidence that PBP2a and PBP1b also appear to be low-affinity variants and are encoded by distinct alleles in beta-lactam-resistant transformants of S. pneumoniae obtained with chromosomal donor DNA from a Streptococcus mitis isolate. Different lineages of beta-lactam-resistant pneumococcal transformants were analyzed, and transformants with low-affinity variants of all high-molecular-mass PBPs, PBP2x, -2a, -2b, -1a, and -1b, were isolated. The MICs of benzyl-penicillin, oxacillin, and cefotaxime for these transformants were up to 40, 100, and 50 microg/ml, respectively, close to the MICs for the S. mitis donor strain. Recruitment of low-affinity PBPs was accompanied by a decrease in cross-linked muropeptides as revealed by high-performance liquid chromatography of muramidase-digested cell walls, but no qualitative changes in muropeptide chemistry were detected. The growth rates of all transformants were identical to that of the parental S. pneumoniae strain. The results stress the potential for the acquisition by S. pneumoniae of high-level beta-lactam resistance by interspecies gene transfer.
177 citations
Authors
Showing all 1888 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Fernand Labrie | 110 | 885 | 48308 |
| Lionel H. Opie | 84 | 519 | 25964 |
| Alain Bélanger | 70 | 244 | 16469 |
| Michel J. Tremblay | 53 | 273 | 10485 |
| Pierre Monsan | 51 | 216 | 8049 |
| Samir Z. Zard | 50 | 575 | 10739 |
| Alejandro Aruffo | 47 | 123 | 14084 |
| Samuel S.C. Yen | 47 | 96 | 6865 |
| Dominique Maraninchi | 47 | 188 | 8108 |
| Serge Erlinger | 46 | 152 | 8200 |
| Romain Lefebvre | 40 | 221 | 5269 |
| William B. Motherwell | 39 | 305 | 6357 |
| Jean-Pierre Raynaud | 38 | 104 | 5075 |
| André Lemay | 38 | 114 | 4264 |
| Patrick J. Creaven | 32 | 102 | 3435 |