Institution
Roussel Uclaf
About: Roussel Uclaf is a based out in . It is known for research contribution in the topics: Alkyl & Alkoxy group. The organization has 1888 authors who have published 2338 publications receiving 36508 citations.
Topics: Alkyl, Alkoxy group, Aryl, Carbon, Carboxylic acid
Papers published on a yearly basis
Papers
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TL;DR: The Active Center of the 3-Oxosteroid Δ1-dehydrogenase from Arthrobacter simplex is represented as a cleft in the protein molecule one side of which is in contact with the α-face of the steroid, the other side being located a few tenths of nanometer above the β-face.
Abstract: The Active Center of the 3-Oxosteroid Δ1-dehydrogenase from Arthrobacter simplex
The kinetic parameters of the semi-purified, hydrocortisone induced 3-oxosteroid Δ1-dehydrogenase from Arthrobacter simplex have been determined with twenty different steroids. The values thus obtained with nortestosterone and six of its stereoisomers and with derivatives bearing substituents at positions 10, 13 and 17, show that for the reaction to take place, first the presence of a 3-oxo group, a Δ4-double bond and axial hydrogens at 1α and 2β positions, are necessary, secondly no bulky substituents must be present in the middle part of the α-face and at position 4; thirdly at positions 10β and 13β no substituents with more than two carbon atoms must be present. With steroids bearing a methyl group in position 10, the chirality of this center has to be natural, and with 19-norsteroids, the conformation of the whole molecule has to be almost flat.
The active center could be represented as a cleft in the protein molecule one side of which is in contact with the α-face of the steroid, the other side being located a few tenths of nanometer above the β-face, The Δ4-double bond is required for the reaction but not for binding. There is no contact point in the area of carbon atom 17.
12 citations
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TL;DR: Reference compounds for the subsequent identification of the metabolites of the potent estrogen, moxestrol (R 2858) in various species were isolated from the bile of phenobarbital pretreated rats or obtained via enzymatic hydroxylation by microorganisms.
12 citations
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TL;DR: In this paper, a new preparation of dihydro-γ-pyrones derived from forskolin 1 is reported, in which the cuprates are added in good yield in BF3-Et2O.
12 citations
Authors
Showing all 1888 results
Name | H-index | Papers | Citations |
---|---|---|---|
Fernand Labrie | 110 | 885 | 48308 |
Lionel H. Opie | 84 | 519 | 25964 |
Alain Bélanger | 70 | 244 | 16469 |
Michel J. Tremblay | 53 | 273 | 10485 |
Pierre Monsan | 51 | 216 | 8049 |
Samir Z. Zard | 50 | 575 | 10739 |
Alejandro Aruffo | 47 | 123 | 14084 |
Samuel S.C. Yen | 47 | 96 | 6865 |
Dominique Maraninchi | 47 | 188 | 8108 |
Serge Erlinger | 46 | 152 | 8200 |
Romain Lefebvre | 40 | 221 | 5269 |
William B. Motherwell | 39 | 305 | 6357 |
Jean-Pierre Raynaud | 38 | 104 | 5075 |
André Lemay | 38 | 114 | 4264 |
Patrick J. Creaven | 32 | 102 | 3435 |