Roussel Uclaf

About: Roussel Uclaf is a based out in . It is known for research contribution in the topics: Alkyl & Alkoxy group. The organization has 1888 authors who have published 2338 publications receiving 36508 citations.

Steroid derivatives substituted in the 11-beta position, process for their preparation, their utilization as medicaments and compositions containing them

Abstract: L'invention concerne les composes (I'): The invention relates to compounds (I '): ou R 1 est un radical organique (1-18c), contenant un azote, un phosphore ou un silicium, R 2 un radical hydrocarbone (1-8c), X le reste d'un cycle pentagonal ou hexagonal eventuellement substitue et insature C=A un groupe oxo libre ou bloque ou un wherein R 1 is an organic radical (1-18c), containing nitrogen, phosphorus or silicon, R 2 is a hydrocarbon radical (1-8C), X the residue of a pentagonal or hexagonal ring optionally substituted and unsaturated C = At a free oxo group or a blocked or (alc 1 , alc 2 , alc 3 = alcoyle (1-8c) ou aralcoyle (7-15c) ) et B et C forment une double liaison ou un pont epoxyde. (alk 1, alk 2, alk 3 = alkyl (1-8C) or aralkyl (7-15c)) and B and C form a double bond or an epoxide bridge. L'invention concerne egalement le procede et les intermediaires de preparation des composes (I'), leur application comme medicaments, notamment antiglucocorticoides et les compositions les renfermant. The invention also relates to the process and intermediates for preparing the compounds (I '), their use as medicaments, in particular antiglucocorticoid and compositions containing them.

Enzymatic protection against peroxidative damage in isolated brain capillaries.

Abstract: The content of polyunsaturated fatty acids, the activities of superoxide dismutase (SOD), glutathione peroxidase, glutathione reductase, and catalase, and the concentration of reduced glutathione were measured in cerebral microvessels isolated from rat brain. Polyunsaturated fatty acids, mainly arachidonic, linoleic, and docosahexaenoic acids, accounted for 32% of total fatty acids in cerebral microvessels. Whereas total SOD activity in the microvessels was slightly lower than that found in cerebrum and cerebellum, glutathione peroxidase and glutathione reductase activities were twice as high and catalase activity was four times higher. Glutathione peroxidase in microvessels is active on both hydrogen peroxide and cumen hydroperoxide, and it is strongly inhibited by mercaptosuccinate. After several hours of preparation, the concentration of reduced glutathione in isolated microvessels was 0.7 mumol/mg of protein, which corresponds to a concentration of approximately 3.5 mM. Our results indicate that the blood-brain barrier contains large amounts of peroxide-detoxifying enzymes, which may act, in vivo, to protect its highly polyunsaturated membranes against oxidative alterations.