Roussel Uclaf

About: Roussel Uclaf is a based out in . It is known for research contribution in the topics: Alkyl & Alkoxy group. The organization has 1888 authors who have published 2338 publications receiving 36508 citations.

Derivatives of 7-ethynyle alpha-(methoxymethylene)1-naphthalenacetic acid, their process of preparation and their use as pesticides

Abstract: The application relates to the products (I): in which: - R represents H, halogen or alkyl which is linear, branched or cyclic, optionally interrupted by one or a number of O, S or N, or R represents optionally substituted aryl, aryloxy or heterocyclic aryl or with p = 0 to 6, or R represents with Ra, Rb and Rc = alkyl or R represents with a and b = H, halogen, OH, alkyl or alkoxy or a and b together form a cycloalkyl and R' has one of the values of R, - R2 and R3 represent H, alkyl or to their process of preparation and to their application as pesticidal agent.

Novel Δ4 -androstenes

Abstract: Novel Δ4 -androstenes of the formula ##STR1## wherein R1 is alkyl of 1 to 3 carbon atoms, Y is selected from the group consisting of hydrogen, fluorine and methyl, R2 is selected from the group consisting of saturated and unsaturated alkyl of 1 to 12 carbon atoms, --CF3, aryl of 6 to 12 carbon atoms and aralkyl of 7 to 12 carbon atoms and the dotted lines in the A and B rings indicate the optional presence of one or two double bonds in the 1(2) and 6(7)-positions with the proviso that when R1 is methyl, R2 is saturated or unsaturated alkyl and the B ring is saturated, Y is methyl having anti-inflammatory activity and novel intermediates.

Effects of RU 52583, an α2-antagonist, on Memory in Rats With Excitotoxic Damage to the Septal Area

Abstract: The anti-amnesic action of RU 52583, an alpha 2-adrenergic receptor antagonist, was evaluated through performance of spatial tasks in a radial maze by rats with N-methyl-D-aspartic acid (NMDA) lesion of the medial septal (MS) nuclei. Memory performance of lesioned or sham-operated rats was evaluated by measuring reference memory as long-term maintenance of an acquired performance and working memory or memory for recent events. The lesion: a produced significant impairments of the animals' memory performance, b) significantly reduced the sodium-dependent high-affinity choline uptake in the hippocampal formation, and c) deeply disrupted cholinergic hippocampal theta waves. Oral administration of RU 52583 at 1 and 2 mg/kg (tested doses: 1-5 mg/kg) prior to performance of the task markedly reduced memory impairments, whereas idazoxan, another alpha 2-adrenergic receptor antagonist, had no effect at tested doses (2-5 mg/kg). Cholinergic drugs--arecoline at 0.1 and 1 mg/kg (tested doses: 0.05-1 mg/kg) and physostigmine at 0.02 and 0.1 mg/kg (tested doses: 1, 2, and 5 mg/kg)-administered intraperitoneally showed a tendency to alleviate memory deficits. The present results show that the alpha 2-adrenergic antagonist RU 52583 possesses cognition-enhancing properties in rats with damage to the septohippocampal system.

Process for the preparation of 17-alpha-hydroxy-17-beta-hydroxyacetyl steroids, and corresponding intermediates obtained

Abstract: The present application relates to a process for the preparation of products of formula: in which: R1 = H, Alk C1-4 optionally substituted Alkenyl or alkynyl C2-4 R2 = Alk C1-4 A, B, C, D optionally bear one or more double bonds and are optionally substituted, starting from products comprising at 17 a radical: R3 = H, protective group, by the action of an acetoxylation agent, then of a hydrolysis agent and finally a deacetoxylation agent.